DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment raskol and Rasal2

DIOPT Version :9

Sequence 1:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	XP_006496813.1	Gene:	Rasal2 / 226525	MGIID:	2443881	Length:	1289	Species:	Mus musculus

Alignment Length:	1471	Identity:	404/1471 - (27%)
Similarity:	610/1471 - (41%)	Gaps:	467/1471 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   586 EKACRRGSAPTTPILGSKQHQTEHNATSRF--TNFFSKK-SNPLKRTKSVTKLERT--------- 638
            |::.||.|...|. ...|.:..:...||.|  ..||||: ...:|||||.:||:|.
Mouse   156 ERSPRRRSISGTS-TSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLR 219

  Fly   639 -----KRGSGGLRGSRSHESLLSSHAVMSTIDLSCTGAVGVAPVHQSVLGRRHCFQVRGGPRGER 698
                 .||...|:.|||||||||..:.:..:||.....|.|.|:|.|:||:..||:|. ...|.:
Mouse   220 NADDRSRGLPKLKESRSHESLLSPCSAVECLDLGRGEPVSVKPLHSSILGQDFCFEVT-YLSGSK 283

  Fly   699 YYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLPPKKRYFCELQLDKTLYGRT 763
            .:||.|..|||.|:.:||:::.||.::.||.:|.|::|:.|||:|.|||:|||||.||.||:.||
Mouse   284 CFSCSSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFART 348

  Fly   764 SVKLQTDLLFWGEHFDFPDIPEINVITVNVFREVDKKKKRDKYQFVGSVKIPVHDVTSRLPCEQW 828
            :.|.:.|.:||||||:|..:|.::.|||:::::|:||||:||..:||.|.||...||.|...|:|
Mouse   349 TSKTKADNIFWGEHFEFYSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKW 413

  Fly   829 YPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTDILPINVYGNFLTYLKENYKRVCE 893
            ||:.:..  .:.|:|.|            |::|||.|||:..|||:..|..|..::..||..:|.
Mouse   414 YPVSTPT--PNKGKTGG------------PSIRIKSRFQTITILPMEQYKEFAEFITSNYTMLCS 464

  Fly   894 TLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGDQR-LTFRGNSLATKSMEAFL 957
            .|||||.|:.||::..|||.::.:.|.|..||||:|..::.|.|:.. |.||.|::||||:|.:|
Mouse   465 VLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYL 529

  Fly   958 KLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAVRGAWQCIFESHKH 1022
            ||.|:|||.|.|...|..|.:|:.:|||||:|.|.|   .|...|:.|:.....|:..|..|:..
Mouse   530 KLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSS---ELMDHQSNLKMCCELAFCKIINSYCV 591

  Fly  1023 FPAQLRNCFATFRERLQQLGRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSARATRNLTL 1087
            ||.:|:..||:::::....|:||:::.|||||:|||||||||:||||||:..|.|..|.:|.|||
Mouse   592 FPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTL 656

  Fly  1088 VAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEIISTRPEHPAPDSILD---WAGYID 1149
            :||.:|.||||.:|..||.:|.|:|||||.|...|::||..||.      ||:|.:   :.||||
Mouse   657 IAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISN------PDTISNTPGFDGYID 715

  Fly  1150 QGKQLSILHSLLSESLAKLP-------EARQHELDPLQHILDEIS--------------RAKEHG 1193
            .|::||:|||||.|.:::|.       :|...:|.||..:|.:|:              |..||.
Mouse   716 LGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFAEHS 780

  Fly  1194 MGTALPGGYL---------PATSSTHSIASENQENRNPGSSG------SHAGSNS---------E 1234
            ....:.|...         |..|..|.:.|.:|:|.:....|      ..|.|.|         |
Mouse   781 SSPNVSGSLSSGLQRICEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDEKE 845

  Fly  1235 QLLP----------QQSQLAQPQHAIVSKPLSAERGIMRGVLTPNSLEKNIFRYNDPTVNGLLQQ 1289
            ..||          |.:..||.:||.|.  |.....:....|:...:         .::..|.:.
Mouse   846 NSLPNGRSISLMDLQDTHAAQAEHASVM--LDVPMRLAGSQLSITQV---------ASIKQLRET 899

  Fly  1290 QQQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQMLSNSQTSIAGNQYMSSPGGLQHAQSQTSMA 1354
            |...|...|.::..|..|.|.|..|....|:|:..|:|.
Mouse   900 QSTPQSAPQVRRPLHPALNQPGSLQPLSFQNPVYHLNNP-------------------------- 938

  Fly  1355 SSSLNGSSSNLLHGHQQHAHHPQQLHPHHCPPAPQTSASSTMERMDRMNYPYMSHNGNDYETSTP 1419
                                         .|..|:.||.|::|.:...:....| |..|::.|.|
Mouse   939 -----------------------------VPAMPKASADSSLENLSTASSRSQS-NSEDFKLSGP 973

  Fly  1420 SSTRSRTLPRNGNPNANGNVGSSNNNQSGSYDDMHGEFQIQISGFDTSSAFVCKSPTPMMKSSLG 1484
            |::......:..:       .|.:.::..:..|.|....:                 |...|:
Mouse   974 SNSSMEDFTKRSS-------HSEDFSRRHTVPDRHIPLAL-----------------PRQNST-- 1012

  Fly  1485 PAGAGRSH-HKLNLGIPDHSGGYVRGNNLNPNSNMPKNLEDLDDLFKYAEEHDVAEPANHHNHNQ 1548
                |:|. .||     ||||       |...:..|.:|.
Mouse  1013 ----GQSQIRKL-----DHSG-------LGARAKAPPSLP------------------------- 1036

  Fly  1549 GQQNHQGHLKPAAVPGKEQLSAKSSHCSSGYQSISTNPSPSQSSSPVESQLKAAMGSHNAPLAFK 1613
                |...|:                 |:|..|::   |.:..:.||::      ||.:
Mouse  1037 ----HSASLR-----------------STGSMSVA---SAALMAEPVQN------GSRS------ 1065

  Fly  1614 NPSYQLQPQTGSSRSSAQSNTHQQQQQQQQQQFGSRLKPIGGGLVAARAAFLNSGGALEAATLTP 1678
                  :.|:.|||.|........|:||.||.    ..|:                  ::||::|
Mouse  1066 ------RQQSSSSRESPVPKVRAIQRQQTQQV----QSPV------------------DSATMSP 1102

  Fly  1679 SSSDEQLSADNYFSYAAAAAAGAGIATKLEAQRSLSGGSSSSTSASASTSNLGKSGGSSAYGRLN 1743
                                          .:|                         :|...||
Mouse  1103 ------------------------------VER-------------------------TAAWVLN 1112

  Fly  1744 GPLKREDVYGSGYGGSSGNVGYGLSTSSAAGHHQHPHQQQQNPMQQQQQRERDQEHKQYAGSVAG 1808
            .....|||                            .:.:||..:.:...:.:||
Mouse  1113 NGQYEEDV----------------------------EETEQNQDEAKHAEKYEQE---------- 1139

  Fly  1809 SVGSATSAAQRRLSLDSARTLSDSSTDTEGHCNQLQEGKRRRQLRSSGGSGGGGAGSEQGLGKSY 1873
                 .:..:.||.:.|.|               |:|.:||..::            ||.:.|
Mouse  1140 -----ITKLKERLRVSSRR---------------LEEYERRLLVQ------------EQQMQK-- 1170

  Fly  1874 DQNGEIQLLQQTLDTLCHTLDRDEAELRDSSDELFGLQRPAGSNGSNNLSLQSESTMRSIIDSFF 1938
                  .||:.            :|.|.||.:.|...|.            :.:|.|:|||.
Mouse  1171 ------LLLEY------------KARLEDSEERLRRQQE------------EKDSQMKSIIS--- 1202

  Fly  1939 QSSCRLITMEEELRREQLKMSLALSHKQRVIEEQ---GQQI 1976
                ||:.:||||:::..:|...:..||::|:.|   |.:|
Mouse  1203 ----RLMAVEEELKKDHAEMQAVIDAKQKIIDAQVINGNEI 1239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	50/130 (38%)
		PH	<656..720	CDD:278594	23/63 (37%)
		C2_SynGAP_like	721..874	CDD:175980	69/152 (45%)
		RasGAP	856..1185	CDD:214617	150/339 (44%)
		RasGAP_DAB2IP	865..1192	CDD:213338	148/351 (42%)
Rasal2	XP_006496813.1	PH-like	181..364	CDD:388408	81/183 (44%)
		C2_SynGAP_like	306..445	CDD:175980	69/152 (45%)
		RasGAP_DAB2IP	436..766	CDD:213338	147/338 (43%)
		DUF3498	756..1232	CDD:371844	137/837 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834579
Domainoid	1	1.000	123	1.000	Domainoid score	I5556
eggNOG	1	0.900	-	-		E1_KOG3508
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	529	1.000	Inparanoid score	I1209
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000844
OrthoInspector	1	1.000	-	-		otm42791
orthoMCL	1	0.900	-	-		OOG6_102644
Panther	1	1.100	-	-	LDO	PTHR10194
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2053
SonicParanoid	1	1.000	-	-		X495
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.820