Protein Alignment raskol and Rasal2

DIOPT Version :10

• Sequence 1: NP_001285388.1
• Gene: raskol / 32754
• FlyBaseID: FBgn0261570
• Length: 2016
• Species: Drosophila melanogaster
• Sequence 2: XP_006496813.1
• Gene: Rasal2 / 226525
• MGIID: 2443881
• Length: 1289
• Species: Mus musculus
• Alignment Length: 1471
• Identity: 404/1471 - (27%)
• Similarity: 610/1471 - (41%)
• Gaps: 467/1471 - (31%)

  Fly   586 EKACRRGSAPTTPILGSKQHQTEHNATSRF--TNFFSKK-SNPLKRTKSVTKLERT--------- 638
            |::.||.|...|. ...|.:..:...||.|  ..||||: ...:|||||.:||:|.
Mouse   156 ERSPRRRSISGTS-TSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLR 219

  Fly   639 -----KRGSGGLRGSRSHESLLSSHAVMSTIDLSCTGAVGVAPVHQSVLGRRHCFQVRGGPRGER 698
                 .||...|:.|||||||||..:.:..:||.....|.|.|:|.|:||:..||:|. ...|.:
Mouse   220 NADDRSRGLPKLKESRSHESLLSPCSAVECLDLGRGEPVSVKPLHSSILGQDFCFEVT-YLSGSK 283

  Fly   699 YYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLPPKKRYFCELQLDKTLYGRT 763
            .:||.|..|||.|:.:||:::.||.::.||.:|.|::|:.|||:|.|||:|||||.||.||:.||
Mouse   284 CFSCSSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFART 348

  Fly   764 SVKLQTDLLFWGEHFDFPDIPEINVITVNVFREVDKKKKRDKYQFVGSVKIPVHDVTSRLPCEQW 828
            :.|.:.|.:||||||:|..:|.::.|||:::::|:||||:||..:||.|.||...||.|...|:|
Mouse   349 TSKTKADNIFWGEHFEFYSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQFVEKW 413

  Fly   829 YPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTDILPINVYGNFLTYLKENYKRVCE 893
            ||:.:..  .:.|:|.|            |::|||.|||:..|||:..|..|..::..||..:|.
Mouse   414 YPVSTPT--PNKGKTGG------------PSIRIKSRFQTITILPMEQYKEFAEFITSNYTMLCS 464

  Fly   894 TLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGDQR-LTFRGNSLATKSMEAFL 957
            .|||||.|:.||::..|||.::.:.|.|..||||:|..::.|.|:.. |.||.|::||||:|.:|
Mouse   465 VLEPVISVRNKEELACALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYL 529

  Fly   958 KLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAVRGAWQCIFESHKH 1022
            ||.|:|||.|.|...|..|.:|:.:|||||:|.|.|   .|...|:.|:.....|:..|..|:..
Mouse   530 KLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSS---ELMDHQSNLKMCCELAFCKIINSYCV 591

  Fly  1023 FPAQLRNCFATFRERLQQLGRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSARATRNLTL 1087
            ||.:|:..||:::::....|:||:::.|||||:|||||||||:||||||:..|.|..|.:|.|||
Mouse   592 FPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTL 656

  Fly  1088 VAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEIISTRPEHPAPDSILD---WAGYID 1149
            :||.:|.||||.:|..||.:|.|:|||||.|...|::||..||.      ||:|.:   :.||||
Mouse   657 IAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISN------PDTISNTPGFDGYID 715

  Fly  1150 QGKQLSILHSLLSESLAKLP-------EARQHELDPLQHILDEIS--------------RAKEHG 1193
            .|::||:|||||.|.:::|.       :|...:|.||..:|.:|:              |..||.
Mouse   716 LGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVLADITKSLTNPTPIQQQLRRFAEHS 780

  Fly  1194 MGTALPGGYL---------PATSSTHSIASENQENRNPGSSG------SHAGSNS---------E 1234
            ....:.|...         |..|..|.:.|.:|:|.:....|      ..|.|.|         |
Mouse   781 SSPNVSGSLSSGLQRICEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDEKE 845

  Fly  1235 QLLP----------QQSQLAQPQHAIVSKPLSAERGIMRGVLTPNSLEKNIFRYNDPTVNGLLQQ 1289
            ..||          |.:..||.:||.|.  |.....:....|:...:         .::..|.:.
Mouse   846 NSLPNGRSISLMDLQDTHAAQAEHASVM--LDVPMRLAGSQLSITQV---------ASIKQLRET 899

  Fly  1290 QQQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQMLSNSQTSIAGNQYMSSPGGLQHAQSQTSMA 1354
            |...|...|.::..|..|.|.|..|....|:|:..|:|.
Mouse   900 QSTPQSAPQVRRPLHPALNQPGSLQPLSFQNPVYHLNNP-------------------------- 938

  Fly  1355 SSSLNGSSSNLLHGHQQHAHHPQQLHPHHCPPAPQTSASSTMERMDRMNYPYMSHNGNDYETSTP 1419
                                         .|..|:.||.|::|.:...:....| |..|::.|.|
Mouse   939 -----------------------------VPAMPKASADSSLENLSTASSRSQS-NSEDFKLSGP 973

  Fly  1420 SSTRSRTLPRNGNPNANGNVGSSNNNQSGSYDDMHGEFQIQISGFDTSSAFVCKSPTPMMKSSLG 1484
            |::......:..:       .|.:.::..:..|.|....:                 |...|:
Mouse   974 SNSSMEDFTKRSS-------HSEDFSRRHTVPDRHIPLAL-----------------PRQNST-- 1012

  Fly  1485 PAGAGRSH-HKLNLGIPDHSGGYVRGNNLNPNSNMPKNLEDLDDLFKYAEEHDVAEPANHHNHNQ 1548
                |:|. .||     ||||       |...:..|.:|.
Mouse  1013 ----GQSQIRKL-----DHSG-------LGARAKAPPSLP------------------------- 1036

  Fly  1549 GQQNHQGHLKPAAVPGKEQLSAKSSHCSSGYQSISTNPSPSQSSSPVESQLKAAMGSHNAPLAFK 1613
                |...|:                 |:|..|::   |.:..:.||::      ||.:
Mouse  1037 ----HSASLR-----------------STGSMSVA---SAALMAEPVQN------GSRS------ 1065

  Fly  1614 NPSYQLQPQTGSSRSSAQSNTHQQQQQQQQQQFGSRLKPIGGGLVAARAAFLNSGGALEAATLTP 1678
                  :.|:.|||.|........|:||.||.    ..|:                  ::||::|
Mouse  1066 ------RQQSSSSRESPVPKVRAIQRQQTQQV----QSPV------------------DSATMSP 1102

  Fly  1679 SSSDEQLSADNYFSYAAAAAAGAGIATKLEAQRSLSGGSSSSTSASASTSNLGKSGGSSAYGRLN 1743
                                          .:|                         :|...||
Mouse  1103 ------------------------------VER-------------------------TAAWVLN 1112

  Fly  1744 GPLKREDVYGSGYGGSSGNVGYGLSTSSAAGHHQHPHQQQQNPMQQQQQRERDQEHKQYAGSVAG 1808
            .....|||                            .:.:||..:.:...:.:||
Mouse  1113 NGQYEEDV----------------------------EETEQNQDEAKHAEKYEQE---------- 1139

  Fly  1809 SVGSATSAAQRRLSLDSARTLSDSSTDTEGHCNQLQEGKRRRQLRSSGGSGGGGAGSEQGLGKSY 1873
                 .:..:.||.:.|.|               |:|.:||..::            ||.:.|
Mouse  1140 -----ITKLKERLRVSSRR---------------LEEYERRLLVQ------------EQQMQK-- 1170

  Fly  1874 DQNGEIQLLQQTLDTLCHTLDRDEAELRDSSDELFGLQRPAGSNGSNNLSLQSESTMRSIIDSFF 1938
                  .||:.            :|.|.||.:.|...|.            :.:|.|:|||.
Mouse  1171 ------LLLEY------------KARLEDSEERLRRQQE------------EKDSQMKSIIS--- 1202

  Fly  1939 QSSCRLITMEEELRREQLKMSLALSHKQRVIEEQ---GQQI 1976
                ||:.:||||:::..:|...:..||::|:.|   |.:|
Mouse  1203 ----RLMAVEEELKKDHAEMQAVIDAKQKIIDAQVINGNEI 1239

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	50/130 (38%)
		C2_SynGAP_like	721..874	CDD:175980	69/152 (45%)
		RasGAP_DAB2IP	865..1192	CDD:213338	148/351 (42%)
		DUF3498	<1927..1997	CDD:463427	18/53 (34%)
Rasal2	XP_006496813.1	PH-like	181..364	CDD:473070	81/183 (44%)
		C2_SynGAP_like	306..445	CDD:175980	69/152 (45%)
		RasGAP_DAB2IP	436..766	CDD:213338	147/338 (43%)
		DUF3498	756..1232	CDD:463427	137/837 (16%)