DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment raskol and gap-2

DIOPT Version :9

Sequence 1:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	NP_509596.1	Gene:	gap-2 / 181172	WormBaseID:	WBGene00001516	Length:	1259	Species:	Caenorhabditis elegans

Alignment Length:	1221	Identity:	368/1221 - (30%)
Similarity:	550/1221 - (45%)	Gaps:	268/1221 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   400 SATSILTHSFPPKNLFLLKSTPKLSTDIAAATPP-----NTSAICSPPK-------KSLSFIRRA 452
            |.|:...||        ..|||:.:....:||..     ||.|:...||       |.|....|.
Worm    22 SNTTTCAHS--------TSSTPRSTYSSGSATSSLPLYVNTHAVTEQPKAEKRVSFKDLDMSGRL 78

  Fly   453 HSTKVARSNSLLKPNQAGILGSGSGSNGLGVHQ------GVMQGALS---------ISCAGDNSS 502
            ..|....|:|      :..|.:|.|.:...:|:      .:::..||         |.......:
Worm    79 PVTAQQPSSS------SNHLRTGGGLHARKLHRCDTGNMSLLERYLSRENMHTPSPIPQEYQPQA 137

  Fly   503 NNGSWGKHFYQPYDVCPLSLDELNCYFQADQ--------------CEKLICERFKIR-------- 545
            |..|...||.|.....|         ||.||              |:.|....|..|
Worm   138 NYSSRHVHFAQSQSRRP---------FQRDQRNENASIRKRLSRSCDHLSDHNFSPRLPPIRRKP 193

  Fly   546 --------DLAIHMA-------SASAIGAD-------LSVTTENETTATAD----------DDAG 578
                    .|.||.|       ..:.:|.:       ...:|.|.||.||.          ..:.
Worm   194 TKHVPSTLSLVIHDAIHDETNSGGAQVGGESLDRRGWSGASTGNRTTLTASVHNNLMNGRMSSSS 258

  Fly   579 HHSDTSYEKACRRGSAPTT----PILGSKQHQTEHNATSRFTNFFSK--KSNPLKRTKSVTKLER 637
            |:..|....:.:..:.||.    ||:....:.::.:|:.|..|..|:  :||||||||||:|:|:
Worm   259 HNLSTRLSGSTQNLNQPTNAYGFPIVPPANNPSDSSASGRIANLLSRPFRSNPLKRTKSVSKMEK 323

  Fly   638 T------------------KRGS------------------GGLRGSRSHESLLSSHAVMSTIDL 666
            :                  .|.|                  |.||..|||||||||......|:|
Worm   324 SLAEANQHSLHRVDASNTPSRDSSLYAQPPARRHLSQPAREGSLRACRSHESLLSSAHSTHMIEL 388

  Fly   667 SCTGAVGVAPVHQSVLGRRHCFQVRGGPRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDN 731
            :....  :.|||.|:....:||::     ...||||.:..||..|:.:|||::.|..:..|||:|
Worm   389 NEDNR--LHPVHPSIFEVPNCFRL-----ASTYYSCRTPLERAKWMENLRKTMNPRRDQQRRTEN 446

  Fly   732 SLKMWVYEAKNLPPKKRYFCELQLDKTLYGRTSVKLQTDLLFWGEHFDFPDIPEINVITVNVFRE 796
            |:.:|:.|||.||.|::|:||:.||||||.:||.|.:||.:||||:|:|..:|:|:.:.|::|||
Worm   447 SMLIWILEAKGLPAKRKYYCEMTLDKTLYAKTSSKARTDNVFWGENFEFMMLPKIDEVCVSLFRE 511

  Fly   797 VDKKKKRDKYQFVGSVKIPVHDVTSRLPCEQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLR 861
            .|.|||:|  ..:|.|.|.:..::||.|.|:||.:.:..:.....|.:...| |....::.|:||
Worm   512 SDSKKKKD--TLIGYVTIGIDQLSSRSPVERWYTVNTSHSDSGTSRIASALG-GKSSSQESPSLR 573

  Fly   862 IKCRFQSTDILPINVYGNFLTYLKENYKRVCETLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLT 926
            ||.|:||..|||:..|.|.|..|..||..:||.||||:.|:.|||:..:||.:|:...||..||.
Worm   574 IKARWQSVHILPLRAYDNLLETLCYNYLPLCEQLEPVLNVRDKEDLATSLVRVMYKHNLAKEFLC 638

  Fly   927 DVVALDLLRVGDQRLTFRGNSLATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTS 991
            |::..::.::.:..|.||||:||||:||:|:||..:.||..|||..|..::|.|..|||||.|..
Worm   639 DLIMKEVEKLDNDHLMFRGNTLATKAMESFMKLVADDYLDSTLSDFIKTVLQCEDSCEVDPQKLG 703

  Fly   992 GSSAGSLQRQQAALRGAVRGAWQCIFESHKHFPAQLRNCFATFRERLQQLGRQDMADNLISASIF 1056
            ..|..||::.:|.|...|..||..|..:....|..||:.|:..|.||:...|:.:||.|||:|||
Worm   704 NVSNSSLEKNRALLMRYVEVAWTKILNNVHQLPKNLRDVFSALRCRLEAQNREALADTLISSSIF 768

  Fly  1057 LRFLCPAILSPSLFNITSELPSARATRNLTLVAKTLQTLANFTRFQGKENFMEFLNDFLEQEAAR 1121
            |||||||||||||||:.||.||....|||||:|||||.||||::|.|||..|||:|:|:::|..|
Worm   769 LRFLCPAILSPSLFNLVSEYPSPTNARNLTLIAKTLQNLANFSKFGGKEPHMEFMNEFVDREWHR 833

  Fly  1122 MQQFLEIISTR----PEHPAPDSILDWAGYIDQGKQLSILHSLLSESLAKLPEAR---QHELDPL 1179
            |:.||..||:.    ||..| |:|      :|.||:||::.:.|.|:...|.:.:   :|.|..:
Worm   834 MKDFLLRISSESKSGPEKNA-DAI------VDAGKELSLIATYLEEAWTPLLQEKNGNKHPLSNV 891

  Fly  1180 QHILDEISRAKE-------HGMGTALPGG---------------YLPATSSTHSIASENQENRNP 1222
            :.:|.|::..|.       |......|..               .:||..||..........|:.
Worm   892 KSVLSELAECKRRSDNGVFHSPMVQQPSSDYENSPQQHVVPRHENVPAYRSTPPTGQATVLGRST 956

  Fly  1223 GSSGSHAGSNSEQLLPQQSQLAQPQHAIVSKPLSAERGIMRGVLTPNSLEKNIFRYNDPTVNGLL 1287
            ....:|..::.:.:|  .|....|........||.|.|      |.:|      |.:|.|.:
Worm   957 NRPATHLLTSDDYVL--SSAFQTPSLRPGGTRLSDETG------TSSS------RTSDKTTS--- 1004

  Fly  1288 QQQQQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQMLSNSQTSIAGNQYMS-SPGGLQHAQSQT 1351
                 ..:.:.......:..:..|...:...:.|....|.|.:..|.:.|:| :|....::.|.:
Worm  1005 -----SAEIRDDTDSDFELREDRGRGGRNRKRLPRTDASPSSSQQASSGYLSNNPSRSSYSNSSS 1064

  Fly  1352 S-----MASSSLNGSSSNLLHG-------------------------------HQQHAHHPQQLH 1380
            |     ||:.|:    :|.:.|                               |..| :.|.|::
Worm  1065 SSPVERMAALSI----ANPVFGPGPSSGYAIPAEPKEIVYQKRASPPPYDPDVHNYH-YQPMQVY 1124

  Fly  1381 --PHHCPPAPQTSASSTMERMDRMNYPYMSHNGNDYETSTPSSTRSRTLPR 1429
              |..|..:|:|.|:..:...:|::.|          .:.|.::|:.||.|
Worm  1125 AVPPDCQVSPRTQATGGVNAQNRLSLP----------RTNPRASRNSTLLR 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	48/151 (32%)
		PH	<656..720	CDD:278594	20/63 (32%)
		C2_SynGAP_like	721..874	CDD:175980	66/152 (43%)
		RasGAP	856..1185	CDD:214617	153/335 (46%)
		RasGAP_DAB2IP	865..1192	CDD:213338	150/340 (44%)
gap-2	NP_509596.1	PH-like	302..494	CDD:302622	76/198 (38%)
		C2_SynGAP_like	436..586	CDD:175980	66/152 (43%)
		RasGAP	564..909	CDD:214617	155/351 (44%)
		RasGAP_DAB2IP	577..905	CDD:213338	150/334 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158201
Domainoid	1	1.000	108	1.000	Domainoid score	I4049
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	1	1.000	-	-		FOG0000844
OrthoInspector	1	1.000	-	-		oto19404
orthoMCL	1	0.900	-	-		OOG6_102644
Panther	1	1.100	-	-	LDO	PTHR10194
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2053
SonicParanoid	1	1.000	-	-		X495
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.880