DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment raskol and RASA4

DIOPT Version :9

Sequence 1:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	XP_016867150.1	Gene:	RASA4 / 10156	HGNCID:	23181	Length:	840	Species:	Homo sapiens

Alignment Length:	963	Identity:	210/963 - (21%)
Similarity:	363/963 - (37%)	Gaps:	234/963 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   560 DLSVTTENETTATADDDAGHHSDTSYEKACRRGSAPTTPILGSKQHQTEHNATSRFTNFFSKKSN 624
            |::.:::.......|::....:.|.::..|        |..| :::|.....|.....|:....:
Human    21 DITGSSDPYCIVKVDNEPIIRTATVWKTLC--------PFWG-EEYQVHLPPTFHAVAFYVMDED 76

  Fly   625 PLKRTKSVTKLERTKRGSGGLRGSRSHESLLSSHAVMSTIDLSCTGAVGVAPVHQSVLGRRHCFQ 689
            .|.|...:.|:..|:....      ||....|..|.::.:|           ..:.|.|..|
Human    77 ALSRDDVIGKVCLTRDTIA------SHPKGFSGWAHLTEVD-----------PDEEVQGEIH--- 121

  Fly   690 VRGGPRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLPPKKRYFCELQ 754
                                     ||..:.|.|...|     |:..|.||::|.||.|......
Human   122 -------------------------LRLEVWPGARACR-----LRCSVLEARDLAPKDRNGTSDP 156

  Fly   755 LDKTLY-GR---TSVKLQTDLLFWGEHFDFPDIPE--INVITVNVFREVDKKKKRDKYQFVGSVK 813
            ..:..| ||   ||:..::....|.|.|:| ::.|  :..:.|..: :.|...:.|   |:|.|.
Human   157 FVRVRYKGRTRETSIVKKSCYPRWNETFEF-ELQEGAMEALCVEAW-DWDLVSRND---FLGKVV 216

  Fly   814 IPVHDVTSRLPCEQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTDILPINVYG 878
            |.|..:......|.|:.:..|::           .|...|:..|.:|:::.|.:...:||.:.|.
Human   217 IDVQRLRVVQQEEGWFRLQPDQS-----------KSRRHDEGNLGSLQLEVRLRDETVLPSSYYQ 270

  Fly   879 NFLTYLKENYK-------RVCETLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRV 936
            ..:..|....|       ::...:|.....:.::|:...|:.|...||||..||..:..|:|.|.
Human   271 PLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRT 335

  Fly   937 GDQRLTFRGNSLATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGS---- 997
            .:....||.||||:||||:|||:.|.|||...|...||::.:.::..|:||:|......|.
Human   336 SETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLH 400

  Fly   998 --------LQRQQAALRGAVRGAWQCIFESHKHFPAQLRNCFATFRERLQQL-----GRQDMADN 1049
                    |::....||..:......:..|.:..||.:|   ||||:..:::     |.|.....
Human   401 RPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVR---ATFRQLFRRVRERFPGAQHENVP 462

  Fly  1050 LISASIF--LRFLCPAILSPSLFNITSELPSARATRNLTLVAKTLQTLANF--TRFQGKENFMEF 1110
            .|:.:.|  |||..|||:||.||::......||.:|.|.|:||.:|.:.|.  ...:.||.:||.
Human   463 FIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEP 527

  Fly  1111 LNDFLEQEAARMQQFL----------EI-------ISTRPEHPAPDSILDWAGYIDQGKQLS--- 1155
            |...:.|..|:::.|:          |:       :...|....|..|....|   :|..:|
Human   528 LQPTVRQGVAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKG---KGPLMSSSF 589

  Fly  1156 --ILHSLLSESL--AKLPEARQHELDPLQHILDEISRAKEHGMGTALPGGYLPATSSTHSIASEN 1216
              :..||.:|:|  ||.|.:::..|..|.:|.                             |:|.
Human   590 KKLYFSLTTEALSFAKTPSSKKSALIKLANIR-----------------------------AAEK 625

  Fly  1217 QENRNPGSSGSHAGSNSEQLLPQQSQLAQPQHAI--------VSKPLSAERGIM---RGVLTPNS 1270
            .|.:      |..||:..|:: ......:||.|.        :::.|||.|.:.   .|:|  .|
Human   626 VEEK------SFGGSHVMQVI-YTDDAGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLL--GS 681

  Fly  1271 LEKNIFRYNDPTVNGLLQQQQQQQQQQQQQQQQHQQLQQ------HGHQQQPHHQHPLQMLSNSQ 1329
            ....:||.:    ......|:::..|...:.:....||:      |..:.|..::|.|.:
Human   682 YHPGVFRGD----KWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGV----- 737

  Fly  1330 TSIAGNQYMSSPGGLQHAQSQTS--MASSSLNGSSS-----NLLHGHQQHAHH--PQQLHPHHCP 1385
            .::...::....||.:.....||  ...|...|:.|     ..:||....||.  |.:|   ..|
Human   738 EAMLWERHRELSGGAEAGTVPTSPGKGRSCPPGTCSWPEPPPEMHGWGPRAHSQGPSRL---PLP 799

  Fly  1386 PAPQTSASSTMERMDRMNYPYMSHNGNDYETSTPSSTRSRTLPRNGNPNANGN 1438
            ..|:.|.:..:..:..:         .:..:|:|:          |:|.:..|
Human   800 TVPEDSLARLLRVLQDL---------REAHSSSPA----------GSPPSEPN 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	18/113 (16%)
		PH	<656..720	CDD:278594	8/63 (13%)
		C2_SynGAP_like	721..874	CDD:175980	38/158 (24%)
		RasGAP	856..1185	CDD:214617	105/380 (28%)
		RasGAP_DAB2IP	865..1192	CDD:213338	103/378 (27%)
RASA4	XP_016867150.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144452
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840