DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment raskol and rasal3

DIOPT Version :9

Sequence 1:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	XP_002935455.2	Gene:	rasal3 / 100488943	XenbaseID:	XB-GENE-6048180	Length:	1009	Species:	Xenopus tropicalis

Alignment Length:	1068	Identity:	279/1068 - (26%)
Similarity:	459/1068 - (42%)	Gaps:	218/1068 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   441 PPKKSLSFIRRAHSTKVARSNSLLKPNQAGILGSGSGSNGLGVHQGVMQGALSISCAGDNSSNNG 505
            ||.:.|:....:.|.::.|... ::|:..||.|.        |...|...|..|..
Frog    76 PPSRGLTKYLHSVSQRLGRKKD-IRPSLDGIEGP--------VPLPVPVSAPEIPV--------- 122

  Fly   506 SWGKHFYQPYDVCPLSLDELNCYFQADQCEKLICERFKIRDLAIHMASASAIGADLSVTTENETT 570
                     :|:...||.: .|.......|:..|          |:.|.:......|:|.:.:.|
Frog   123 ---------WDISNFSLID-GCLLLTKGDEQGAC----------HIRSRTGSCVSKSLTEQTDQT 167

  Fly   571 ATADDDAGHHSDTSYEKACRRGSAPTTPILGSKQHQTEHNATSRFTN----FFSKKSNPLKRTKS 631
            ....|                   |..|     :...:.:..::|.|    ...:|....::..|
Frog   168 DGVVD-------------------PPVP-----EGNVDPDTKNQFNNVKGLIQKRKKKKTRKKGS 208

  Fly   632 VTKLERTKRGSGGLRGSRSHESLLSSHAVMSTIDLSCTGAVGVAPVHQSVLGRRHCFQVRGGPRG 696
            .:.|::.:|   .|.|||  |||    ..:..:||.....|.:..:|.|:||.|:||::... ..
Frog   209 ASSLQQEER---SLHGSR--ESL----GGVEILDLVNEKDVTIKALHSSILGERYCFEIITA-ES 263

  Fly   697 ERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLP---PKKR--YFCELQLD 756
            .|.::|.|.||||.||.:||:.:.|:.::..|.::||.:|::|||.||   |..|  ||||:|||
Frog   264 SRCFACSSLQERDRWIENLRRIVQPDKDNFERQESSLSLWIHEAKGLPVSGPGSRSCYFCEVQLD 328

  Fly   757 KTLYGRTSVKL-QTDLLFWGEHFDFPDIPEI-NVITVNVFREVDKKKKRDKYQFVGSVKIPVHDV 819
            ..||||||.|. :..::||||.|:..|:..: ..:.:::.:|..:...      ||:|.:.:..:
Frog   329 GCLYGRTSSKAPEAGVVFWGESFNLRDLSSVQGHMALHLLQEGKETTG------VGTVTLALEGM 387

  Fly   820 TSRLPCEQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTDILPINVYGNFLTYL 884
            ..  ..|:|.|:..:.|                       ||::.|::...:||:..|..|..||
Frog   388 KD--GAEKWVPLGGEMA-----------------------LRVRGRYRKLSVLPVMQYKEFAEYL 427

  Fly   885 KENYKRVCETLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLR-VGDQRLTFRGNSL 948
            ...|..:...:||::..:.||::|::||.::.:.|.|..||.|:...::.| .|...|.||.|::
Frog   428 TWRYMELSRAMEPILSAREKEELGRSLVYVLQSTGKAKEFLVDLGVAEISRHDGQDSLIFRENTI 492

  Fly   949 ATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTS----GSSAGSLQRQQAALRGAV 1009
            .||::|.::|:.|:.|||:||...:|.:..||...||||.:.|    |.:.|.|.|       :.
Frog   493 VTKAIEEYMKMVGQTYLQETLGPFVNRIYTSEDSHEVDPLRCSPEDLGENRGQLWR-------SC 550

  Fly  1010 RGAWQCIFESHKHFPAQLRNCFATFRERLQQLGRQDMADNLISASIFLRFLCPAILSPSLFNITS 1074
            ..|.|.|.:|.:.||..|...|::::..:...||..:...|:|||:||||||||||||.|||:::
Frog   551 EDAVQSILQSQESFPPDLLEIFSSWQVEVALRGRPALGSRLVSASLFLRFLCPAILSPGLFNLSA 615

  Fly  1075 ELPSARATRNLTLVAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEIISTRPEHPAPD 1139
            |.|...|.|.||||||.||.|||||||..||.:|.|:|.||||....|..||:.::......:|.
Frog   616 EHPQPLAARALTLVAKVLQNLANFTRFGEKEEYMGFMNGFLEQYGDGMSVFLQAVADPESEVSPT 680

  Fly  1140 SILDWAGYIDQGKQLSILHSLLSESLAKLPEARQHELDPLQHILDEISRAKEHGMGTALPGGYLP 1204
            .   :....|...:|::|||:||.....:.:..:.:|:||..||..::.           |..:|
Frog   681 R---YESSADLAYELAVLHSMLSGIFTGVHQQTKDQLEPLPTILKALTE-----------GQPVP 731

  Fly  1205 ATSSTHS-IASENQENRNP---------------GSSGSHAGSNSEQLLP--------------- 1238
            |:.:.|: ..:.::||.:|               ..|.|.:....|:|.|
Frog   732 ASITEHTDYDNRDEENDDPVFVTPRDLSKLRPLVNRSQSMSSLLRERLPPPTRSEFLEKKSRRHV 796

  Fly  1239 --QQSQLAQPQHAIVSKPLSAERGI----------MRGVLTPNSL---EKNIFRYNDPTVNGLLQ 1288
              .||..||.:.....:.::.|:|.          :..|..|::|   :..:....:..:..|.|
Frog   797 TRTQSVPAQGRAGRERRRVTEEKGTEDNTLLKIQKLPRVRPPSTLPRRKSTVPWCRNENIPHLGQ 861

  Fly  1289 -QQQQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQMLSNSQTSIAGNQYMSSPGGL-------- 1344
             .::...|::|.|:.:.|.|:..|.|:.          ...|..|...|.....|.|
Frog   862 GAEEAVNQEKQLQEMRGQILENQGKQKD----------LEGQIGILSGQIQEMLGQLAKVEETQR 916

  Fly  1345 ---QHAQSQTSMASSSLNGSSSNLLHGHQQHAHHP-QQLHPHHCPPAPQTSASSTMERMDRMNYP 1405
               :....|.|:..:.:.......|......|.:| :.:..:|      ..|....|:.|..:..
Frog   917 TFQEEMAGQVSLILNRIKALEEKKLPKENSVAENPAENIEDNH------LLAQINEEQKDSEDPS 975

  Fly  1406 YMSHNGNDYETSTPSSTRSRTLPRNGNP 1433
            .:.:..||.|.::.||..|  ||.| ||
Frog   976 NICNGENDPEITSTSSESS--LPTN-NP 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	35/117 (30%)
		PH	<656..720	CDD:278594	21/63 (33%)
		C2_SynGAP_like	721..874	CDD:175980	44/159 (28%)
		RasGAP	856..1185	CDD:214617	123/333 (37%)
		RasGAP_DAB2IP	865..1192	CDD:213338	121/331 (37%)
rasal3	XP_002935455.2	PH-like	172..311	CDD:388408	45/172 (26%)
		C2	288..417	CDD:387358	44/159 (28%)
		RasGAP_DAB2IP	408..731	CDD:213338	122/343 (36%)
		BexC_CtrB_KpsE	<863..968	CDD:130083	19/120 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10255
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	1	1.000	-	-		FOG0000844
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10194
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X495
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.020