Protein Alignment raskol and rasal2

DIOPT Version :9

• Sequence 1: NP_001285388.1
• Gene: raskol / 32754
• FlyBaseID: FBgn0261570
• Length: 2016
• Species: Drosophila melanogaster
• Sequence 2: XP_004914087.1
• Gene: rasal2 / 100379974
• XenbaseID: XB-GENE-5795955
• Length: 1279
• Species: Xenopus tropicalis
• Alignment Length: 1615
• Identity: 428/1615 - (26%)
• Similarity: 675/1615 - (41%)
• Gaps: 471/1615 - (29%)

  Fly   492 LSISCAGDNSSNNGSWGKHFYQPYDVCPLSLDE-------LNCYFQADQCEKLICER-FKIRDLA 548
            :.:|..||:.::    |..|:|..|..|..||.       |:.......|::....| :.::...
 Frog     4 MDLSPGGDSVTS----GHDFFQDRDSLPEDLDSPGGVGGILDRILMESVCQQQGWVRVYDVKGPP 64

  Fly   549 IHMASASAIGADLSVT--------TENETTATADDD--AGHHS-----DTSYEKACRR------- 591
            .|..|........|.|        ||::......||  .|..:     ::|..::.||
 Frog    65 THRLSCGQSPYTESTTWERKYCILTESQLVLLNRDDEMPGETAQDPPPESSKSRSLRRTVSVPSE 129

  Fly   592 GSAPTTPILGS-----------KQHQTEHNATSRFTN--------------FFSKK-SNPLKRTK 630
            |..|..|..|:           ::......:||..||              ||||: ...:||||
 Frog   130 GQFPDYPPEGAAKLEVPAERSPRRRSISGTSTSDKTNAMDPANTSPFKVSGFFSKRLKGSIKRTK 194

  Fly   631 SVTKLERT---------------KRGSGGLRGSRSHESLLSSHAVMSTIDLSCTGAVGVAPVHQS 680
            |.:||:|.               .||...|:.|||||||||..:.:..:||.....:.|.|:|.|
 Frog   195 SQSKLDRNTSFRLPSLRPAESDRSRGLPKLKESRSHESLLSPGSAVEALDLGTEDKILVKPLHSS 259

  Fly   681 VLGRRHCFQVRGGPRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLPP 745
            :||:..||:|... .|.:.:||.|..|||.|:.:||:::.||.::.||.:|.|::|:.|||:|.|
 Frog   260 ILGQDFCFEVTYS-SGSKCFSCSSAAERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAP 323

  Fly   746 KKRYFCELQLDKTLYGRTSVKLQTDLLFWGEHFDFPDIPEINVITVNVFREVDKKKKRDKYQFVG 810
            ||:|||||.||.||:.||:.|.:.|.:||||:|:|..:|.::.|||:::::|:||||:||..:||
 Frog   324 KKKYFCELCLDDTLFARTTSKTKADNIFWGEYFEFYGLPPLHNITVHIYKDVEKKKKKDKNNYVG 388

  Fly   811 SVKIPVHDVTSRLPCEQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTDILPIN 875
            .|.||:..||.|...|:|||:.:..|  :.|:|.|            |::|||.|:|:..|||:.
 Frog   389 LVNIPMISVTGRQFVEKWYPVSTPTA--NKGKTVG------------PSIRIKSRYQTITILPME 439

  Fly   876 VYGNFLTYLKENYKRVCETLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGDQR 940
            .|..|..::..||..:|..|||||.|:.||::..|||.::.:.|.|..||||:|..::.|.|:..
 Frog   440 QYKEFAEFITINYTMLCSVLEPVISVRNKEEMACALVHILQSTGRAKDFLTDLVMSEVDRCGEHD 504

  Fly   941 -LTFRGNSLATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAA 1004
             |.||.|:||||::|.:|||.|::||.|.|...|..|.:|:.:|||||:|.|.|   .|...|:.
 Frog   505 VLIFRENTLATKAIEEYLKLVGQKYLHDALGEFIKALYESDENCEVDPSKCSSS---ELSDHQSN 566

  Fly  1005 LRGAVRGAWQCIFESHKHFPAQLRNCFATFRERLQQLGRQDMADNLISASIFLRFLCPAILSPSL 1069
            |:.....|:..|..|:..||.:|:..||:::::....|:||:::.|||||:|||||||||:||||
 Frog   567 LKMCCELAFCKIINSYCVFPRELKEVFASWKQQCINRGKQDISERLISASLFLRFLCPAIMSPSL 631

  Fly  1070 FNITSELPSARATRNLTLVAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEIISTRPE 1134
            |.:..|.|..|.:|.|||:||.:|.||||.:|..||.:|.|:|||||.|...|::||:.||.
 Frog   632 FGLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLQEISN--- 693

  Fly  1135 HPAPDSILD---WAGYIDQGKQLSILHSLLSESLAKLP-------EARQHELDPLQHILDEISRA 1189
               ||:|.:   :.||||.|::||:|||||.|.:::|.       :|...:|.||..||.:|:::
 Frog   694 ---PDTISNTPGFEGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVEKLGPLPRILADITKS 755

  Fly  1190 KEHGMGTALPGGYLPATSSTHSIASENQENRNPGSSGSHAGSNSEQLL--PQQSQLAQPQHAIVS 1252
            ..:            .|.....:...::.:..|..||| ..|..:::.  |..|.|.:.:...:.
 Frog   756 LTN------------PTPIQQQLRRFSEHSSTPNVSGS-LSSGLQKIFEDPADSDLQRFRSPTIE 807

  Fly  1253 KPLSAERGIMRGVLTPNSLEKNIFRYNDPTVNGLLQQQQQQQQQQQQQQQQHQQLQQHGHQQQPH 1317
            .|.|..||            |.:          ||.||...|......:.:.:.:..:|....
 Frog   808 NPESYFRG------------KTL----------LLVQQASTQSMSFSDKDERENVLPNGRSVS-- 848

  Fly  1318 HQHPLQMLSNSQTSIAGNQYMSSPGGLQHAQSQTSMASSSLNGSSSNLLHGHQQHAHHPQQLHPH 1382
                |..|.:|..|......:.....|:...||.|:|..:   :...|...|......||...|.
 Frog   849 ----LMDLQDSNVSHTDRSSVIQEPPLRLTGSQLSIAHVA---TIKQLRENHSMPQSAPQVRKPL 906

  Fly  1383 HCPPAPQTSASSTMERMDRMNYPYMSHNGNDYETSTPSSTRSRTLPRNGNPNANGNVG-SSNNNQ 1446
            |    |..|..|:::.:...|..|..:|        |..    |:|:....::..|:. :|:.:|
 Frog   907 H----PALSQQSSLQPLSFQNPVYHLNN--------PPP----TMPKASVDSSLENLSTASSRSQ 955

  Fly  1447 SGSYDDMHGEFQIQISGFDTSSAFVCKSPTPMMKSSLGPAGAGRSHHKLNLGIPDHSGGYVRGNN 1511
            |.|.:                  |:...|:                   |..:.|.:....:..:
 Frog   956 SNSEE------------------FILSGPS-------------------NSSMEDFTKRSTQSED 983

  Fly  1512 LNPNSNMPKNLEDLDDLFKYAEEHDVAEPANHHNHNQGQQNHQGHLKPAAVP-----GKEQLSAK 1571
            ......||:                  .|.                 |.|:|     |:.|: .|
 Frog   984 FTRRHTMPE------------------RPI-----------------PIALPRQNSTGQAQI-RK 1012

  Fly  1572 SSHCSSGYQSISTNPSPSQSSSPVESQLKAA---MGSHNAPLAFKNPSYQLQPQTGSSRSSAQSN 1633
            :...:.|.:      :.:..|.|..:.|::|   .|..|..|        ::|....:||..||.
 Frog  1013 TDQAALGAR------AKAPQSLPHSASLRSAGSMSGISNNML--------VEPVQNGNRSRQQST 1063

  Fly  1634 T------------HQQQQQQQQQQFGS-RLKPIGGGLVAARAAFLNSGGALEAATLTPSSSDEQL 1685
            :            |:||.||.|....| .:.|     |...||::.:.|..|         ||:.
 Frog  1064 SSRESPVPKLRAIHRQQTQQVQSPVDSATMSP-----VERTAAWVLNNGQYE---------DEEE 1114

  Fly  1686 SADNYFSYAAAAAAGAGIATKLEAQRSLSGGSSSSTSASASTSNLGKSGGSSAYGRLNGPLKRED 1750
            :.|
 Frog  1115 TVD-------------------------------------------------------------- 1117

  Fly  1751 VYGSGYGGSSGNVGYGLSTSSAAGHHQHPHQQQQNPMQQQQQRERDQEHKQYAGSVAGSVGSATS 1815
                                                    |.::..:..::|...:|
 Frog  1118 ----------------------------------------QNKDESKPAEKYEQEIA-------- 1134

  Fly  1816 AAQRRLSLDSARTLSDSSTDTEGHCNQLQEGKRRRQLRSSGGSGGGGAGSEQGLGKSYDQNGEIQ 1880
            ..:.||.:.|.|               |:|.:||..::.                         |
 Frog  1135 KLKERLKISSRR---------------LEEYERRLLVQE-------------------------Q 1159

  Fly  1881 LLQQTLDTLCHTLDRDEAELRDSSDELFGLQRPAGSNGSNNLSLQSESTMRSIIDSFFQSSCRLI 1945
            .:|:.|......|:..|..||...:|                   .:|.|:|:|.       |||
 Frog  1160 QMQKLLMEYKSRLEDSEERLRRQQEE-------------------KDSQMKSVIS-------RLI 1198

  Fly  1946 TMEEELRREQLKMSLALSHKQRVIEEQGQQIAALDAANSRLLSALTALRQRYETQ 2000
            .:||||:::..:|...:..||::|:.|.::|.:|||||:||:||||.:::||.:|
 Frog  1199 AVEEELKKDHAEMQAVIDAKQKIIDAQEKRIISLDAANTRLMSALTQVKERYNSQ 1253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	50/143 (35%)
		PH	<656..720	CDD:278594	22/63 (35%)
		C2_SynGAP_like	721..874	CDD:175980	68/152 (45%)
		RasGAP	856..1185	CDD:214617	148/339 (44%)
		RasGAP_DAB2IP	865..1192	CDD:213338	145/337 (43%)
rasal2	XP_004914087.1	PH-like	173..357	CDD:388408	76/184 (41%)
		C2_SynGAP_like	299..438	CDD:175980	68/152 (45%)
		RasGAP_DAB2IP	429..759	CDD:213338	145/350 (41%)
		DUF3498	749..1241	CDD:371844	136/828 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5143
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	551	1.000	Inparanoid score	I1112
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	1	1.000	-	-		FOG0000844
OrthoInspector	1	1.000	-	-		otm47902
Panther	1	1.100	-	-	LDO	PTHR10194
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X495
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.160