Protein Alignment raskol and rasa3

DIOPT Version :10

• Sequence 1: NP_001285388.1
• Gene: raskol / 32754
• FlyBaseID: FBgn0261570
• Length: 2016
• Species: Drosophila melanogaster
• Sequence 2: XP_009303503.1
• Gene: rasa3 / 100318936
• ZFINID: ZDB-GENE-090313-21
• Length: 853
• Species: Danio rerio
• Alignment Length: 968
• Identity: 193/968 - (19%)
• Similarity: 323/968 - (33%)
• Gaps: 314/968 - (32%)

  Fly   518 CPLSLDELNCYFQADQCEKLIC----ERF------KIRDLAIHMASASAIGADLSVTTENETTAT 572
            |.::||:.. .|:....||.:|    |.|      ..|.|:.::........|.|:   .:....
Zfish    38 CTVNLDQEE-VFRTKTIEKSLCPFYGEDFYCEIPRSFRHLSFYIFDRDVFRRDSSI---GKVAVK 98

  Fly   573 ADDDAGHHSDTSYEKACRRGSAPTTPILGSKQHQTEHNATSRFTNFFSKKSNPLKRTKSVTKLER 637
            .:|...:|....:        .|..|:....:.|             .|....|:.::.:|
Zfish    99 KEDLQKYHGKDHW--------FPLQPVCADSEVQ-------------GKVHLELRLSELIT---- 138

  Fly   638 TKRGSGGLRGSRSHESLLSSHAVMSTIDLSCTGAVGVAPVHQSVLGRRHCFQVRGGPRGERYYSC 702
               .||||    .|:        ::|..|.|..    .|:            |.|        .|
Zfish   139 ---DSGGL----CHK--------LATRVLECQD----LPI------------VNG--------QC 164

  Fly   703 GSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLPPKKRYFCELQLDKTLYGRTSVKL 767
            ..        |:....:.|:....::|.       .:.||..|        |.|:..:    .::
Zfish   165 DP--------YAAVSLLGPSRSEAKKTK-------VKRKNNNP--------QFDEIFF----FEV 202

  Fly   768 QTDLLFWGEHFDFPDIPEINVITVNVFREVDK-KKKRDKY---------QFVGSVKIP------- 815
            ...|.|....||..:            .:||| ..|.|.:         :|:|.|::|
Zfish   203 TKPLSFTKRQFDVEE------------DDVDKLALKVDLWNASNLKFGDEFLGEVRVPLKVLGQA 255

  Fly   816 -VHDVTSRLPCEQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTDILPINVYGN 879
             |||.        || .|..:          ..|..|...::|.:||:...:....:.|...|..
Zfish   256 GVHDA--------WY-FLQPR----------DNGHKSVKADELGSLRLNIVYTEDHVFPTEHYNP 301

  Fly   880 FLTYLKE--NYKRVCETLEPVIG--VKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGDQR 940
            ....|.:  :.:.|..:...::|  .:.|::....||.|....|....||:.:...::.|..|..
Zfish   302 LRDLLLQSAHVQPVSASAAHILGEVCREKQEAAVPLVRLFLHYGKIVPFLSAIAHAEISRTQDPN 366

  Fly   941 LTFRGNSLATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAAL 1005
            ..||||||.:|.::..:||.|..||:.||...|:|:....:.||:||.|...|.  :|...:..|
Zfish   367 TIFRGNSLTSKCIDETMKLAGMHYLRVTLKPIIDEICSDHKPCEIDPVKLKESE--NLDTNRENL 429

  Fly  1006 RGAVRGAWQCIFESHKHFPAQLRNCFATFRE----RLQQLGRQDMADNLISASIFLRFLCPAILS 1066
            |..|...:..|..|....|..:.:.|.:.||    |.|.  ..|:....:|:.|||||..|||||
Zfish   430 RQYVDRIFSVITSSGVSCPTVMCDIFFSLRESAASRFQV--DADVRYTAVSSFIFLRFFAPAILS 492

  Fly  1067 PSLFNITSELPSARATRNLTLVAKTLQTLANFTRFQG---KENFMEFLNDFLEQE--AARMQQFL 1126
            |:||::....|....:|.|||::||:|||.:..:.:.   ||::|....|:..::  |..::.||
Zfish   493 PNLFHLRPHHPDPCTSRTLTLISKTIQTLGSLAKSKSANFKESYMAAFYDYFNEQKYADAVKNFL 557

  Fly  1127 EIISTRPEHPAPDSILDWAGYIDQGKQLSI-LHSLLSESLAKLPEAR------------------ 1172
            ::||         |...|       .|.|| ...:|.|...||...|
Zfish   558 DLIS---------SSARW-------DQKSIETPIMLKEGSVKLIIKRFDAKGSGRFMIKRAQGRN 606

  Fly  1173 ---------------QHELD-----------------PLQH------------------------ 1181
                           .||..                 |:::
Zfish   607 RFGLKNFKKRWFRLTNHEFTYHKTKGNAKGEGALCSIPIENILAVERLEEESFKMKNMFQVIQPE 671

  Fly  1182 ------------------ILDEISRAKEHGMGTALPGGYLPATSSTHSIASENQENRNPGSSGSH 1228
                              ||.::|:.....:.|..|..:|    :.|.:..:...:..||.:...
Zfish   672 RALYIQANNCVEARDWIDILTKVSQCNRKRLSTFHPSAFL----NGHWLCCKLSADTAPGCTPCT 732

  Fly  1229 AG------------SNSEQLL----PQQSQLAQPQHAIVSKPLSAERGIMRGVLTPNSLEKNIFR 1277
            .|            ..:|::.    ...|:|.:.|.|..||      .:..|   |...|.:.|.
Zfish   733 GGLPANIQLDVDGDRETERIYSLYSTYMSKLVKMQEACGSK------SVYDG---PEQEEYSTFV 788

  Fly  1278 YNDP-----TVNGLLQQQQQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQMLSNSQT 1330
            .:||     |:..::...|..:||..|.::...:..::|.|:.|......|.....|:
Zfish   789 IDDPQETYKTLRLVISAVQTLEQQHTQYKRDKFRKTKYGSQEHPIGDQSFQCYIRQQS 846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	17/113 (15%)
		C2_SynGAP_like	721..874	CDD:175980	31/170 (18%)
		RasGAP_DAB2IP	865..1192	CDD:213338	98/432 (23%)
		DUF3498	<1927..1997	CDD:463427
rasa3	XP_009303503.1	C2A_RasA2_RasA3	13..133	CDD:176046	20/119 (17%)
		C2B_RasA3	146..287	CDD:175977	39/230 (17%)
		RasGAP	296..563	CDD:470620	81/279 (29%)
		PH-like	561..705	CDD:473070	17/159 (11%)
		BTK	698..733	CDD:128417	6/38 (16%)