DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment raskol and rasa3

DIOPT Version :9

Sequence 1:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	XP_009303503.1	Gene:	rasa3 / 100318936	ZFINID:	ZDB-GENE-090313-21	Length:	853	Species:	Danio rerio

Alignment Length:	959	Identity:	191/959 - (19%)
Similarity:	324/959 - (33%)	Gaps:	296/959 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   518 CPLSLDELNCYFQADQCEKLIC----ERF------KIRDLAIHMASASAIGADLSVTTENETTAT 572
            |.::||:.. .|:....||.:|    |.|      ..|.|:.::........|.|:   .:....
Zfish    38 CTVNLDQEE-VFRTKTIEKSLCPFYGEDFYCEIPRSFRHLSFYIFDRDVFRRDSSI---GKVAVK 98

  Fly   573 ADDDAGHHSDTSYEKACRRGSAPTTPILGSKQHQTEHNATSRFTNFFSKKSNPLKRTKSVTKLER 637
            .:|...:|....:        .|..|:....:.|             .|....|:.::.:|
Zfish    99 KEDLQKYHGKDHW--------FPLQPVCADSEVQ-------------GKVHLELRLSELIT---- 138

  Fly   638 TKRGSGGLRGSRSHESLLSSHAVMSTIDLSCTGAVGVAPVHQSVLGRRHCFQVRGGPRGERYYSC 702
               .||||    .|:        ::|..|.|..    .|:            |.|        .|
Zfish   139 ---DSGGL----CHK--------LATRVLECQD----LPI------------VNG--------QC 164

  Fly   703 GSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLPPKKRYFCELQLDKTLYGRTSVKL 767
            ..        |:....:.|:....::|.       .:.||..|        |.|:..:    .::
Zfish   165 DP--------YAAVSLLGPSRSEAKKTK-------VKRKNNNP--------QFDEIFF----FEV 202

  Fly   768 QTDLLFWGEHFDFPDIPEINVITVNV-FREVDKKKKRDKYQFVGSVKIP--------VHDVTSRL 823
            ...|.|....||..: .:::.:.:.| .......|..|  :|:|.|::|        |||.
Zfish   203 TKPLSFTKRQFDVEE-DDVDKLALKVDLWNASNLKFGD--EFLGEVRVPLKVLGQAGVHDA---- 260

  Fly   824 PCEQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTDILPINVYGNFLTYLKE-- 886
                || .|..:          ..|..|...::|.:||:...:....:.|...|......|.:
Zfish   261 ----WY-FLQPR----------DNGHKSVKADELGSLRLNIVYTEDHVFPTEHYNPLRDLLLQSA 310

  Fly   887 NYKRVCETLEPVIG--VKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGDQRLTFRGNSLA 949
            :.:.|..:...::|  .:.|::....||.|....|....||:.:...::.|..|....||||||.
Zfish   311 HVQPVSASAAHILGEVCREKQEAAVPLVRLFLHYGKIVPFLSAIAHAEISRTQDPNTIFRGNSLT 375

  Fly   950 TKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAVRGAWQ 1014
            :|.::..:||.|..||:.||...|:|:....:.||:||.|...|.  :|...:..||..|...:.
Zfish   376 SKCIDETMKLAGMHYLRVTLKPIIDEICSDHKPCEIDPVKLKESE--NLDTNRENLRQYVDRIFS 438

  Fly  1015 CIFESHKHFPAQLRNCFATFRE----RLQQLGRQDMADNLISASIFLRFLCPAILSPSLFNITSE 1075
            .|..|....|..:.:.|.:.||    |.|.  ..|:....:|:.|||||..||||||:||::...
Zfish   439 VITSSGVSCPTVMCDIFFSLRESAASRFQV--DADVRYTAVSSFIFLRFFAPAILSPNLFHLRPH 501

  Fly  1076 LPSARATRNLTLVAKTLQTLANFTRFQG---KENFMEFLNDFLEQE--AARMQQFLEIISTRPEH 1135
            .|....:|.|||::||:|||.:..:.:.   ||::|....|:..::  |..::.||::||
Zfish   502 HPDPCTSRTLTLISKTIQTLGSLAKSKSANFKESYMAAFYDYFNEQKYADAVKNFLDLIS----- 561

  Fly  1136 PAPDSILDWAGYIDQGKQLSI-LHSLLSESLAKLPEAR--------------------------- 1172
                |...|       .|.|| ...:|.|...||...|
Zfish   562 ----SSARW-------DQKSIETPIMLKEGSVKLIIKRFDAKGSGRFMIKRAQGRNRFGLKNFKK 615

  Fly  1173 ------QHELD-----------------PLQH--------------------------------- 1181
                  .||..                 |:::
Zfish   616 RWFRLTNHEFTYHKTKGNAKGEGALCSIPIENILAVERLEEESFKMKNMFQVIQPERALYIQANN 680

  Fly  1182 ---------ILDEISRAKEHGMGTALPGGYLPATSSTHSIASENQENRNPGSSGSHAG------- 1230
                     ||.::|:.....:.|..|..:|    :.|.:..:...:..||.:....|
Zfish   681 CVEARDWIDILTKVSQCNRKRLSTFHPSAFL----NGHWLCCKLSADTAPGCTPCTGGLPANIQL 741

  Fly  1231 -----SNSEQLL----PQQSQLAQPQHAIVSKPLSAERGIMRGVLTPNSLEKNIFRYNDP----- 1281
                 ..:|::.    ...|:|.:.|.|..||      .:..|   |...|.:.|..:||
Zfish   742 DVDGDRETERIYSLYSTYMSKLVKMQEACGSK------SVYDG---PEQEEYSTFVIDDPQETYK 797

  Fly  1282 TVNGLLQQQQQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQMLSNSQT 1330
            |:..::...|..:||..|.::...:..::|.|:.|......|.....|:
Zfish   798 TLRLVISAVQTLEQQHTQYKRDKFRKTKYGSQEHPIGDQSFQCYIRQQS 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	17/113 (15%)
		PH	<656..720	CDD:278594	8/63 (13%)
		C2_SynGAP_like	721..874	CDD:175980	29/161 (18%)
		RasGAP	856..1185	CDD:214617	100/434 (23%)
		RasGAP_DAB2IP	865..1192	CDD:213338	98/432 (23%)
rasa3	XP_009303503.1	C2A_RasA2_RasA3	13..133	CDD:176046	20/119 (17%)
		C2B_RasA3	146..287	CDD:175977	37/221 (17%)
		RasGAP	278..629	CDD:214617	97/370 (26%)
		RasGAP	296..563	CDD:295371	81/279 (29%)
		PH-like	561..705	CDD:302622	17/159 (11%)
		PH	597..695	CDD:278594	5/97 (5%)
		BTK	698..733	CDD:128417	6/38 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577557
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840