DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment raskol and rasa3

DIOPT Version :9

Sequence 1:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	XP_004911857.1	Gene:	rasa3 / 100144662	XenbaseID:	XB-GENE-920756	Length:	834	Species:	Xenopus tropicalis

Alignment Length:	725	Identity:	165/725 - (22%)
Similarity:	288/725 - (39%)	Gaps:	169/725 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   737 VYEAKNLPPKKRYFCELQLDKTLYG-------RTSVKLQT-----DLLFWGE-----------HF 778
            |.|.:.||..... |:.....||.|       :|.|:.:|     |.:|:.|           ||
Frog   151 VLECQGLPIVNGQ-CDPYATVTLLGPSRSEAKKTKVRKKTNNPQFDEVFYFEVTKPCSYNKKSHF 214

  Fly   779 DFPDIPEINVITVNVFREVDKKKKR-DKY---------QFVGSVKIPVHDVTSRLPCE-QWYPIL 832
            :..:            .:|||.:.| |.:         :|:|.:|||: .|..:..|. .||.:.
Frog   215 EIEE------------DDVDKLEIRVDLWNASNLKFGDEFLGELKIPL-KVLRQSSCHGAWYFLQ 266

  Fly   833 SDKAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTDILPINVYGNF--LTYLKENYKRVCETL 895
            ....|.|:            ..:.|.:||:...:....:.|...|...  |.....:.:.|..:.
Frog   267 PRDNGKSV------------KPDDLGSLRLNVVYTEDHVFPSEYYSPLRDLVLKSGDVEPVSASA 319

  Fly   896 EPVIG--VKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGDQRLTFRGNSLATKSMEAFLK 958
            ..|:|  .:.|::....||.|....|....|::.:...::.|..|....||||||.:|.::..:|
Frog   320 AHVLGEVCREKQEAAIPLVRLFLHYGKIVPFISAIANAEVNRTQDPNTIFRGNSLTSKCIDETMK 384

  Fly   959 LTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAVRGAWQCIFESHKHF 1023
            |.|..|||.||...|:|:.::.:.||:||.|.....  :.:..:..|:..|...:..|.:|....
Frog   385 LAGMHYLQVTLKPIIDEICEAHKPCEIDPVKLKDGE--NFENNKENLKNYVDRIFDVITKSGVSC 447

  Fly  1024 PAQLRNCFATFRE----RLQQLGRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSARATRN 1084
            |..:.:.|.:.||    |.|  |..|:....:|:.|||||..||||||:||.::...|..:.:|.
Frog   448 PTVMCDIFFSLRESAAKRFQ--GDPDVRFTAVSSFIFLRFFAPAILSPNLFQLSPHHPDPQTSRT 510

  Fly  1085 LTLVAKTLQTLANFTRFQG---KENFM-EFLNDFLEQE-AARMQQFLEIIST-------RPEHPA 1137
            |||::||:|||.:.::.:.   |||:| .|..:|.||: |..::.||::||:       |.|.|
Frog   511 LTLISKTIQTLGSLSKSKSASFKENYMAAFYENFNEQKYADAVKNFLDLISSSGRRDHKRIEQP- 574

  Fly  1138 PDSILDWAGYI---DQGKQLSIL------------------------HSLLS---ESLAKLPEAR 1172
               ||...|::   .||::...:                        |.|.|   |::..:.:..
Frog   575 ---ILLKEGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYQKSKAGDHPLCSIPIENILAVEKLE 636

  Fly  1173 QHE---------LDPLQ----------------HILDEISRAKEHGMGTALPGGYLPATSSTHSI 1212
            :..         :.|::                .||.::|:..:..:....|..||.|.......
Frog   637 EESFKMKNMFQVIQPVRTLYIQANNCVEAKDWIDILTKVSQCNKKRLTVYHPSAYLNAHWLCCKA 701

  Fly  1213 ASENQENRNPGSSGSHAG--------SNSEQLLPQQS----QLAQPQHAIVSKPLSAERGIMRGV 1265
            .|||.....|.:.|..|.        ..:|::....:    :|.:.|.|..||      .:..|
Frog   702 TSENAPGCTPCTGGLPANIQLDIDGDRETERIYSLFNTYICKLEKMQEACGSK------SVYDG- 759

  Fly  1266 LTPNSLEKNIFRYNDP-----TVNGLLQQQQQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQML 1325
              |...|.:.|..::|     |:..::...:..:|:..|.::...:..::|.|:.|......|..
Frog   760 --PEQEEYSTFLIDEPRETYKTLYQIIDGVKTLEQEHAQYKRDKFKKTKYGSQEHPIGDKSFQSY 822

  Fly  1326 SNSQTSIAGN 1335
            ...|:.::.:
Frog   823 IRQQSEVSAH 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082
		PH	<656..720	CDD:278594
		C2_SynGAP_like	721..874	CDD:175980	35/170 (21%)
		RasGAP	856..1185	CDD:214617	103/403 (26%)
		RasGAP_DAB2IP	865..1192	CDD:213338	101/401 (25%)
rasa3	XP_004911857.1	C2A_RasA2_RasA3	13..133	CDD:176046
		C2B_RasA3	146..287	CDD:175977	35/161 (22%)
		RasGAP_RASA3	296..564	CDD:213336	84/271 (31%)
		PH_GAP1_mammal-like	561..686	CDD:241522	17/128 (13%)
		BTK	679..714	CDD:128417	8/34 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000