DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment raskol and rasa1

DIOPT Version :9

Sequence 1:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	NP_001107303.1	Gene:	rasa1 / 100135092	XenbaseID:	XB-GENE-6085075	Length:	946	Species:	Xenopus tropicalis

Alignment Length:	777	Identity:	196/777 - (25%)
Similarity:	321/777 - (41%)	Gaps:	152/777 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   484 HQGVM--QGALSISCAGDNSSNNGSWGKHFYQPYDVCPLSLDELNCYFQADQCEKLICERFKIRD 546
            |:|.:  .|.:|...|.:.....|.......:|.|..|   .:.:.||:.::    ..:||||
Frog   245 HEGKIWFHGKISKQEAYNLLMTVGGISSFLVRPSDNTP---GDYSLYFRTNE----NIQRFKI-- 300

  Fly   547 LAIHMASASAIGADLSVTTENETTA------TADDDAGHHSDTSYEKACRRGSAPTTPILGSKQH 605
                           ..|..|:...      :.||...|:.    ::....|.....|:  ..||
Frog   301 ---------------CPTANNQFMMGGRYYNSIDDIIDHYR----KEQIVEGYYLKQPV--PVQH 344

  Fly   606 QTE-----------HNATSRFTN--FFS---KKSNPLKRTKSVTKLERTKRGSGGLRGSRSH--- 651
            |.:           :|...|.|.  |:.   ||...||::|.    :|.|.....|.|:.:.
Frog   345 QEQVLNDFLDGKEIYNTIKRRTKDAFYKNIVKKGYLLKKSKG----KRWKNLYFILEGNDAQLIF 405

  Fly   652 -ESLLSSHAVMSTIDLS-CTGAVGVAPVHQSVLGRRHCFQVRGGPRGER----YYSCGSRQERDL 710
             ||...:.......||| |:    |..||.|:.||.:|||:......|.    |::|.:.::.:.
Frog   406 FESEKRATKPKGLFDLSVCS----VYVVHDSLFGRPNCFQIVVQHFSEEHYIFYFACDTPEQAED 466

  Fly   711 WIYSLR-----KSIAPNAEHTR-RTDNSLKMWVYEAKNLPPK--KRYFCELQLDKTLYGRTSVKL 767
            |:.:|:     :.|..:..:.| |..:||.:.|.||..||.|  ...:|.:||:.....:|..:
Frog   467 WMRTLQAFCCLRKITQSPSNKRLRQVSSLNLHVEEAHKLPMKHFTSPYCNIQLNSVQVAKTHAR- 530

  Fly   768 QTDLLFWGEHFDFPDI-PEINVITVNVFREVDKKKKRDKYQFVGSVKIPVHDVTSRLPCEQWYPI 831
            :.....|.|.|.|.|: |:||...:.:..:..|.|..|    :..::..:..:......::|:.:
Frog   531 EGQNPVWSEEFFFDDLSPDINRFEIILSNKTKKSKDPD----ILFMRCQLSRLQKGQTTDEWFQL 591

  Fly   832 LSDKAGDSLGRTSGGGGSGSKDKEQLP-------TLRIKCRFQSTDILPINVYGNFLTYLKENYK 889
            .|                      .:|       :||::.|:....|:|...|..|...:.:...
Frog   592 SS----------------------HIPLKGIEPGSLRVRARYSMEKIMPEEEYTEFKELILQKEL 634

  Fly   890 RVCETLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLR------VG--DQRLT-FRG 945
            .|...|..|        .||...||  |..|...||.:.:...|||      :|  |:..| ||.
Frog   635 HVVNALSHV--------CGQDRTLL--ASILLRIFLHEKMESLLLRTLNDREIGMEDEATTLFRA 689

  Fly   946 NSLATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSS--AGSLQRQQAALRGA 1008
            .:||:..||.::|.|...::...|...|.::::|::.||::|:|...:.  ..:||.....|...
Frog   690 TTLASTLMEQYMKATATPFVHHALKDTILKILESKQSCELNPSKLEKNEDVNANLQHLLILLSEL 754

  Fly  1009 VRGAWQCIFESHKHFPAQLRNCFATFRERLQQL--GRQDMADNLISASIFLRFLCPAILSPSLFN 1071
            |    :.||.:.:..|..||..:...::.:||.  ....|...::|..:|||.:|||||:|.:||
Frog   755 V----EKIFMAAEILPPTLRYIYGCLQKSVQQKWPSNATMRTRVVSGFVFLRLICPAILNPRMFN 815

  Fly  1072 ITSELPSARATRNLTLVAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEIISTRPEHP 1136
            |.|:.||..|.|.||||||:||.|||...|..||.:||.:|.|::....||..||:.:...||
Frog   816 IISDSPSPTAARTLTLVAKSLQNLANLVEFGAKEPYMEGVNPFIKDNKQRMIMFLDELGNVPE-- 878

  Fly  1137 APDSILDWAGYIDQGKQLSILHSLL---SESLAKLPE---ARQHELDPLQHILDEISRAKEH 1192
            .||:...  ...|..:.|:.||.:.   |:.|..:..   |:||.|..|..| .|:.:.|::
Frog   879 LPDTTEH--SRTDLSRNLAALHEMCVAHSDELRTISNERGAQQHVLKKLLAI-TELLQQKQN 937

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	33/133 (25%)
		PH	<656..720	CDD:278594	18/73 (25%)
		C2_SynGAP_like	721..874	CDD:175980	32/163 (20%)
		RasGAP	856..1185	CDD:214617	108/354 (31%)
		RasGAP_DAB2IP	865..1192	CDD:213338	107/345 (31%)
rasa1	NP_001107303.1	SH2_Nterm_RasGAP	60..163	CDD:198216
		SH3_RasGAP	180..238	CDD:212722
		SH2_Cterm_RasGAP	249..325	CDD:198217	17/99 (17%)
		PH_RASA1	372..475	CDD:270080	29/110 (26%)
		PH	374..475	CDD:278594	29/108 (27%)
		C2_Ras_p21A1	490..615	CDD:176045	30/151 (20%)
		RasGAP	597..939	CDD:214617	109/360 (30%)
		RasGAP_p120GAP	613..944	CDD:213340	106/344 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920