Protein Alignment raskol and syngap1

DIOPT Version :10

• Sequence 1: NP_001285388.1
• Gene: raskol / 32754
• FlyBaseID: FBgn0261570
• Length: 2016
• Species: Drosophila melanogaster
• Sequence 2: XP_031748229.1
• Gene: syngap1 / 100038210
• XenbaseID: XB-GENE-487270
• Length: 1222
• Species: Xenopus tropicalis
• Alignment Length: 1278
• Identity: 377/1278 - (29%)
• Similarity: 572/1278 - (44%)
• Gaps: 238/1278 - (18%)

  Fly   514 PYD-------VCPLSLDELNCYFQADQCEKLICERFKIRDLAIHMASASAIGADLSVTTENETTA 571
            |||       .|.||.::| .....::...|:     ||:..........:...:||..|.:
 Frog    24 PYDRPAWNPRYCVLSGNQL-LMLDEEEVHPLL-----IRERRTDPTRTKFLRRTVSVPVEGK--- 79

  Fly   572 TADDDAGHHSDTSYEKACRRGSAPTTPILGSKQHQTEHNATSRF---TNFFSKK-SNPLKRTKSV 632
             ..|:..:|...|     ||.|.|     |.||...:...|:.|   ..|.|:: .:.:|||||.
 Frog    80 -QPDEHDYHLARS-----RRKSVP-----GGKQPSMDAPPTAPFRPSQGFLSRRLKSSIKRTKSQ 133

  Fly   633 TKLERTK-----------------RGSGGLRGSRSHESLLSSHAVMSTIDLSCTGAVGVAPVHQS 680
            .||:||.                 |.....:.|.|||||||..:....:||:......|.|||.|
 Frog   134 PKLDRTSSFRQILPRFRSADHDRARLMQAFKESHSHESLLSPSSAAEALDLNLDEDSVVKPVHSS 198

  Fly   681 VLGRRHCFQVRGGPRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLPP 745
            :||:..||:|... .|.:.::|.|..|||.||.:|::::.||.:::||.||.||:|:.||::|||
 Frog   199 ILGQEFCFEVTTS-SGTKCFACRSAAERDKWIENLQRAVKPNKDNSRRVDNVLKLWIIEARDLPP 262

  Fly   746 KKRYFCELQLDKTLYGRTSVKLQTDLLFWGEHFDFPDIPEINVITVNVFREVDKKKKRDKYQFVG 810
            ||||:|||.||..||.||:.|.:.|.:||||||:|.::|.:..:.::::::.|||::::|..:||
 Frog   263 KKRYYCELCLDDILYARTTSKPRNDTVFWGEHFEFNNLPAVRNLRLHLYKDTDKKRRKEKSNYVG 327

  Fly   811 SVKIPVHDVTSRLPCEQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTDILPIN 875
            .|.:|:..::.|...|||||:...              :..|.|...|::|:|.|:|:..|||:.
 Frog   328 MVNVPIASISGRHFVEQWYPVSQP--------------TSYKGKSSCPSIRLKSRYQTMSILPME 378

  Fly   876 VYGNFLTYLKENYKRVCETLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGD-Q 939
            :|..|..|:..||:.:|..||||:.||:||::..|||.::.:.|.|..||:|:...::.|..| :
 Frog   379 LYKEFAEYVTNNYRMLCAVLEPVLSVKSKEEVACALVHILQSTGKAKDFLSDMAMTEVDRFLDRE 443

  Fly   940 RLTFRGNSLATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAA 1004
            .|..|.|:||||::|.:|||.|::||::.:...|..|.:||.||||||.:...|   :|...||.
 Frog   444 HLILRENTLATKAIEEYLKLIGQRYLKEAIGEFIRALYESEEDCEVDPMRCPPS---ALPDHQAN 505

  Fly  1005 LRGAVRGAWQCIFESHKHFPAQLRNCFATFRERLQQLGRQDMADNLISASIFLRFLCPAILSPSL 1069
            ||.....|...:|.||..||.:|:..||::|.|..:.||:|:||.|||||:|||||||||:||||
 Frog   506 LRMCCELALCKVFNSHCVFPRELKEVFASWRMRCAERGREDIADRLISASLFLRFLCPAIMSPSL 570

  Fly  1070 FNITSELPSARATRNLTLVAKTLQTLANFT-RFQGKENFMEFLNDFLEQEAARMQQFLEIISTRP 1133
            |::..|.|..:.:|.|||:||.:|.||||. :|..||.:|.|:|:|||.|.|.||.||..||..
 Frog   571 FSLMQEYPDEQTSRTLTLIAKVIQNLANFNYKFSSKEEYMSFMNEFLETELANMQNFLYEISNL- 634

  Fly  1134 EHPAPDSI---LDWAGYIDQGKQLSILHSLLSESLAKLPEARQHELDPLQHILDEISRAKEHGMG 1195
                 ||:   :::.||||.|::||.||:||.|.:.:|.:....:|.||..:|::||
 Frog   635 -----DSLTNSINFEGYIDLGRELSTLHALLWEVIPQLSKDALIKLGPLPRLLNDIS-------- 686

  Fly  1196 TALPGGYLPATSSTHSIASENQENRNPGSSGSHAGSNSEQLLPQQSQLAQPQHAIV--------- 1251
            .||...::....|       :||...|.......|.::|    .||.|.:..::.:
 Frog   687 LALRNPHIQRQPS-------HQERLPPPKPVILRGPSAE----LQSYLVRDLNSSIDMTRLPSPT 740

  Fly  1252 -SKPLSAERGIMRGVLTPNS-----LEKNIFRYNDPTVNGL-LQQQQQQQQQQQQQQQQHQQLQQ 1309
             .||......:.|..||.:|     ...:|   .:|....| :.:.......|..:......||.
 Frog   741 KDKPSKDMFFVSRRPLTRSSPAYCTSSSDI---TEPDQKMLSVNKSVSMMDLQDSRMNSVTNLQA 802

  Fly  1310 HGHQQQPHHQHPLQMLSNSQTSIAGNQYMSSPGGLQHAQSQTSMASS--------SLNGSSSNLL 1366
            .|           .:|::||.||:|.   ..|||.....|.:|:|:.        :.:|.|:..|
 Frog   803 VG-----------DLLNSSQASISGG---LRPGGRLSQGSGSSIAAGLRLSQMGVTTDGLSAQQL 853

  Fly  1367 H---GHQQHAHH---------PQQLHPHHCPPAPQTSAS----STMERMDRMNYPYMSHNGNDYE 1415
            .   ..|....|         |....||...|.....|.    |..|.:....:...||:.:|..
 Frog   854 RIPLSFQNPLFHMAPDGPGGPPSHPAPHRPDPGADAFAPFHGYSKSEDLSSGKHMLHSHSYSDEF 918

  Fly  1416 TSTPSSTRSRTLPRNGN-------PNANGNVGSSNNNQSGSYDDMHGEFQ---IQISGFD-TSSA 1469
            :...|....|.|....|       |......|......|.......|:.|   :|.:... .||.
 Frog   919 SRQGSEFSKRQLSLQDNLQHMLSPPQITIGPGVPRRQDSQPPPLQRGKSQQLTVQAAHKPRPSSG 983

  Fly  1470 FVCKSPTPMMKSSLGPAGAGRSHHKLNLGIPDHSGGYVRGNNLNPNSNMPKNLEDLDDLFKYAEE 1534
            .:.:||.||.       ||.|...:   .:...:||      |.|:.
 Frog   984 NLLQSPEPMY-------GAARIRQQ---SVEKDAGG------LKPSI------------------ 1014

  Fly  1535 HDVAEPANHHNHNQGQQNHQGHLKPAAVPGKEQLSAKSS---HCSSGYQSISTNP--------SP 1588
                  ...|:|.|...|       ...|..|:..|..|   |.|:..:|.....        |.
 Frog  1015 ------TKQHSHAQATLN-------PVTPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYSK 1066

  Fly  1589 SQSSSPVES---------QLKAAMGSHNAPL-AFKNPSYQLQPQTGSSRSSAQSNTHQQQQQQQQ 1643
            |...|.:|.         .||..:...|..| .::......:.||.......||...|.:::.:|
 Frog  1067 SMDESRLERVKEYEEEIYSLKERLLMSNRKLEEYERRLLTQEEQTNKMMQQYQSRLDQSEKRLRQ 1131

  Fly  1644 QQF--GSRLKPIGGGLVAARAAFLNSGGALEAATLTPSSSDEQ 1684
            ||.  .:::|.|...|....|    .||..:..:||.::..|:
 Frog  1132 QQVEKDTQIKSILNRLEMVDA----GGGGDQEGSLTRTNRYEE 1170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	45/134 (34%)
		C2_SynGAP_like	721..874	CDD:175980	60/152 (39%)
		RasGAP_DAB2IP	865..1192	CDD:213338	145/331 (44%)
		DUF3498	<1927..1997	CDD:463427
syngap1	XP_031748229.1	PH_SynGAP	108..296	CDD:270178	77/188 (41%)
		C2_SynGAP_like	238..377	CDD:175980	60/152 (39%)
		RasGAP_DAB2IP	368..692	CDD:213338	147/340 (43%)
		DUF3498	682..1197	CDD:463427	113/576 (20%)