DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment raskol and syngap1

DIOPT Version :9

Sequence 1:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	XP_031748229.1	Gene:	syngap1 / 100038210	XenbaseID:	XB-GENE-487270	Length:	1222	Species:	Xenopus tropicalis

Alignment Length:	1278	Identity:	377/1278 - (29%)
Similarity:	572/1278 - (44%)	Gaps:	238/1278 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   514 PYD-------VCPLSLDELNCYFQADQCEKLICERFKIRDLAIHMASASAIGADLSVTTENETTA 571
            |||       .|.||.::| .....::...|:     ||:..........:...:||..|.:
Frog    24 PYDRPAWNPRYCVLSGNQL-LMLDEEEVHPLL-----IRERRTDPTRTKFLRRTVSVPVEGK--- 79

  Fly   572 TADDDAGHHSDTSYEKACRRGSAPTTPILGSKQHQTEHNATSRF---TNFFSKK-SNPLKRTKSV 632
             ..|:..:|...|     ||.|.|     |.||...:...|:.|   ..|.|:: .:.:|||||.
Frog    80 -QPDEHDYHLARS-----RRKSVP-----GGKQPSMDAPPTAPFRPSQGFLSRRLKSSIKRTKSQ 133

  Fly   633 TKLERTK-----------------RGSGGLRGSRSHESLLSSHAVMSTIDLSCTGAVGVAPVHQS 680
            .||:||.                 |.....:.|.|||||||..:....:||:......|.|||.|
Frog   134 PKLDRTSSFRQILPRFRSADHDRARLMQAFKESHSHESLLSPSSAAEALDLNLDEDSVVKPVHSS 198

  Fly   681 VLGRRHCFQVRGGPRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLPP 745
            :||:..||:|... .|.:.::|.|..|||.||.:|::::.||.:::||.||.||:|:.||::|||
Frog   199 ILGQEFCFEVTTS-SGTKCFACRSAAERDKWIENLQRAVKPNKDNSRRVDNVLKLWIIEARDLPP 262

  Fly   746 KKRYFCELQLDKTLYGRTSVKLQTDLLFWGEHFDFPDIPEINVITVNVFREVDKKKKRDKYQFVG 810
            ||||:|||.||..||.||:.|.:.|.:||||||:|.::|.:..:.::::::.|||::::|..:||
Frog   263 KKRYYCELCLDDILYARTTSKPRNDTVFWGEHFEFNNLPAVRNLRLHLYKDTDKKRRKEKSNYVG 327

  Fly   811 SVKIPVHDVTSRLPCEQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTDILPIN 875
            .|.:|:..::.|...|||||:...              :..|.|...|::|:|.|:|:..|||:.
Frog   328 MVNVPIASISGRHFVEQWYPVSQP--------------TSYKGKSSCPSIRLKSRYQTMSILPME 378

  Fly   876 VYGNFLTYLKENYKRVCETLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGD-Q 939
            :|..|..|:..||:.:|..||||:.||:||::..|||.::.:.|.|..||:|:...::.|..| :
Frog   379 LYKEFAEYVTNNYRMLCAVLEPVLSVKSKEEVACALVHILQSTGKAKDFLSDMAMTEVDRFLDRE 443

  Fly   940 RLTFRGNSLATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAA 1004
            .|..|.|:||||::|.:|||.|::||::.:...|..|.:||.||||||.:...|   :|...||.
Frog   444 HLILRENTLATKAIEEYLKLIGQRYLKEAIGEFIRALYESEEDCEVDPMRCPPS---ALPDHQAN 505

  Fly  1005 LRGAVRGAWQCIFESHKHFPAQLRNCFATFRERLQQLGRQDMADNLISASIFLRFLCPAILSPSL 1069
            ||.....|...:|.||..||.:|:..||::|.|..:.||:|:||.|||||:|||||||||:||||
Frog   506 LRMCCELALCKVFNSHCVFPRELKEVFASWRMRCAERGREDIADRLISASLFLRFLCPAIMSPSL 570

  Fly  1070 FNITSELPSARATRNLTLVAKTLQTLANFT-RFQGKENFMEFLNDFLEQEAARMQQFLEIISTRP 1133
            |::..|.|..:.:|.|||:||.:|.||||. :|..||.:|.|:|:|||.|.|.||.||..||..
Frog   571 FSLMQEYPDEQTSRTLTLIAKVIQNLANFNYKFSSKEEYMSFMNEFLETELANMQNFLYEISNL- 634

  Fly  1134 EHPAPDSI---LDWAGYIDQGKQLSILHSLLSESLAKLPEARQHELDPLQHILDEISRAKEHGMG 1195
                 ||:   :::.||||.|::||.||:||.|.:.:|.:....:|.||..:|::||
Frog   635 -----DSLTNSINFEGYIDLGRELSTLHALLWEVIPQLSKDALIKLGPLPRLLNDIS-------- 686

  Fly  1196 TALPGGYLPATSSTHSIASENQENRNPGSSGSHAGSNSEQLLPQQSQLAQPQHAIV--------- 1251
            .||...::....|       :||...|.......|.::|    .||.|.:..::.:
Frog   687 LALRNPHIQRQPS-------HQERLPPPKPVILRGPSAE----LQSYLVRDLNSSIDMTRLPSPT 740

  Fly  1252 -SKPLSAERGIMRGVLTPNS-----LEKNIFRYNDPTVNGL-LQQQQQQQQQQQQQQQQHQQLQQ 1309
             .||......:.|..||.:|     ...:|   .:|....| :.:.......|..:......||.
Frog   741 KDKPSKDMFFVSRRPLTRSSPAYCTSSSDI---TEPDQKMLSVNKSVSMMDLQDSRMNSVTNLQA 802

  Fly  1310 HGHQQQPHHQHPLQMLSNSQTSIAGNQYMSSPGGLQHAQSQTSMASS--------SLNGSSSNLL 1366
            .|           .:|::||.||:|.   ..|||.....|.:|:|:.        :.:|.|:..|
Frog   803 VG-----------DLLNSSQASISGG---LRPGGRLSQGSGSSIAAGLRLSQMGVTTDGLSAQQL 853

  Fly  1367 H---GHQQHAHH---------PQQLHPHHCPPAPQTSAS----STMERMDRMNYPYMSHNGNDYE 1415
            .   ..|....|         |....||...|.....|.    |..|.:....:...||:.:|..
Frog   854 RIPLSFQNPLFHMAPDGPGGPPSHPAPHRPDPGADAFAPFHGYSKSEDLSSGKHMLHSHSYSDEF 918

  Fly  1416 TSTPSSTRSRTLPRNGN-------PNANGNVGSSNNNQSGSYDDMHGEFQ---IQISGFD-TSSA 1469
            :...|....|.|....|       |......|......|.......|:.|   :|.:... .||.
Frog   919 SRQGSEFSKRQLSLQDNLQHMLSPPQITIGPGVPRRQDSQPPPLQRGKSQQLTVQAAHKPRPSSG 983

  Fly  1470 FVCKSPTPMMKSSLGPAGAGRSHHKLNLGIPDHSGGYVRGNNLNPNSNMPKNLEDLDDLFKYAEE 1534
            .:.:||.||.       ||.|...:   .:...:||      |.|:.
Frog   984 NLLQSPEPMY-------GAARIRQQ---SVEKDAGG------LKPSI------------------ 1014

  Fly  1535 HDVAEPANHHNHNQGQQNHQGHLKPAAVPGKEQLSAKSS---HCSSGYQSISTNP--------SP 1588
                  ...|:|.|...|       ...|..|:..|..|   |.|:..:|.....        |.
Frog  1015 ------TKQHSHAQATLN-------PVTPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYSK 1066

  Fly  1589 SQSSSPVES---------QLKAAMGSHNAPL-AFKNPSYQLQPQTGSSRSSAQSNTHQQQQQQQQ 1643
            |...|.:|.         .||..:...|..| .::......:.||.......||...|.:::.:|
Frog  1067 SMDESRLERVKEYEEEIYSLKERLLMSNRKLEEYERRLLTQEEQTNKMMQQYQSRLDQSEKRLRQ 1131

  Fly  1644 QQF--GSRLKPIGGGLVAARAAFLNSGGALEAATLTPSSSDEQ 1684
            ||.  .:::|.|...|....|    .||..:..:||.::..|:
Frog  1132 QQVEKDTQIKSILNRLEMVDA----GGGGDQEGSLTRTNRYEE 1170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	45/134 (34%)
		PH	<656..720	CDD:278594	22/63 (35%)
		C2_SynGAP_like	721..874	CDD:175980	60/152 (39%)
		RasGAP	856..1185	CDD:214617	146/333 (44%)
		RasGAP_DAB2IP	865..1192	CDD:213338	145/331 (44%)
syngap1	XP_031748229.1	PH_SynGAP	108..296	CDD:270178	77/188 (41%)
		C2_SynGAP_like	238..377	CDD:175980	60/152 (39%)
		RasGAP_DAB2IP	368..692	CDD:213338	147/340 (43%)
		DUF3498	682..1191	CDD:403279	113/576 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5143
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	551	1.000	Inparanoid score	I1112
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	1	1.000	-	-		FOG0000844
OrthoInspector	1	1.000	-	-		otm47902
Panther	1	1.100	-	-	O	PTHR10194
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X495
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070