DRSC/TRiP Functional Genomics Resources

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Protein Alignment raskol and syngap1a

DIOPT Version :9

Sequence 1:NP_001285388.1 Gene:raskol / 32754 FlyBaseID:FBgn0261570 Length:2016 Species:Drosophila melanogaster
Sequence 2:XP_005159373.1 Gene:syngap1a / 100034485 ZFINID:ZDB-GENE-060503-370 Length:1313 Species:Danio rerio


Alignment Length:1510 Identity:428/1510 - (28%)
Similarity:654/1510 - (43%) Gaps:385/1510 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   570 TATADDDAGHHSDTSYEKACRRGSAPTTPILGSKQHQTEHNATS-----RFTNFFSKK-SNPLKR 628
            |.:...|:..|.::.:.:|.|:..|.      |:|...|...|:     |..:|.|:: ...:||
Zfish    73 TVSVPADSRPHPESEHARARRKSFAT------SRQRSMETPPTAPTQPFRQPSFLSRRLKGSIKR 131

  Fly   629 TKSVTKLERT------------------KRGSGGLRGSRSHESLLSSHAVMSTIDLSCTGAVGVA 675
            .||..||:||                  .|.....:.|.|||||||..:....:||:......:.
Zfish   132 AKSQPKLDRTGSFRHMILPRFRSADQERTRLMQSFKESHSHESLLSPSSAAEALDLTLDEDAIIK 196

  Fly   676 PVHQSVLGRRHCFQVRGGPRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEA 740
            |||.|:||:.:||:|... .|.:.::|.|..|||.||.:|::::.||.:::||.||.||:|:.||
Zfish   197 PVHSSILGQEYCFEVTTA-SGTKCFACRSAAERDKWIENLQRAVKPNKDNSRRVDNVLKLWIIEA 260

  Fly   741 KNLPPKKRYFCELQLDKTLYGRTSVKLQTDLLFWGEHFDFPDIPEINVITVNVFREVDKKKKRDK 805
            ::|||||||:|||.||..||.||:.|.:||.:||||||:|.::|.|..:.:::::|.|||::::|
Zfish   261 RDLPPKKRYYCELCLDDMLYARTTSKPRTDTVFWGEHFEFNNLPAIRSLRLHLYKENDKKRRKEK 325

  Fly   806 YQFVGSVKIPVHDVTSRLPCEQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTD 870
            ..::|.|.||:..||.|...|||||::....     ...||||.|   |....:||:|.||||.:
Zfish   326 STYLGLVSIPIPSVTGRQFVEQWYPLIQPSV-----LAKGGGGGG---KIINASLRLKSRFQSMN 382

  Fly   871 ILPINVYGNFLTYLKENYKRVCETLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLR 935
            |||:.:|..|..|:..||:.:|..|||::..|:||::..|||.::.:.|.|..||:|:...::.|
Zfish   383 ILPMELYKEFAEYVTNNYRTLCGVLEPLLSAKSKEEVACALVHILQSTGKAKDFLSDMAMCEVDR 447

  Fly   936 VGD-QRLTFRGNSLATKSMEAFLKLTGEQYLQDTLSAP--INELIQSERDCEVDPTKTSGSSAGS 997
            ..| :.|.||.|:||||::|.||||...:||:||:...  |..|.:||.:|||||.:|..|   .
Zfish   448 FMDREHLIFRENTLATKAIEEFLKLIAHRYLKDTIGEGEFIRALYESEENCEVDPMRTPPS---V 509

  Fly   998 LQRQQAALRGAVRGAWQCIFESHKHFPAQLRNCFATFRERLQQLGRQDMADNLISASIFLRFLCP 1062
            |...||.||.....|...|..||..||.:|:..||::|.|..:.||:|:||.|||:|:|||||||
Zfish   510 LADHQANLRMCCELALCKIINSHCVFPRELKEVFASWRVRCAERGREDIADRLISSSLFLRFLCP 574

  Fly  1063 AILSPSLFNITSELPSARATRNLTLVAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLE 1127
            ||:||||||:|.|.||.|.:|.|||:||.:|:||:|::|.|||:::.|:|:|||.|...|||||.
Zfish   575 AIMSPSLFNLTQEYPSERTSRTLTLIAKVVQSLASFSKFSGKEDYLGFMNEFLEMEWGSMQQFLY 639

  Fly  1128 IISTRPEHPAPDSILD-------WAGYIDQGKQLSILHSLLSESLAKLPEARQHELDPLQHILDE 1185
            .||.          |:       :.||||.|::||||||||.|.:|:|.:....:|.||..:|::
Zfish   640 EISN----------LECVSNAGAFEGYIDLGRELSILHSLLWEVMAQLSKDAILKLGPLPRLLND 694

  Fly  1186 ISRAKEHGMGTALPGGYLPATSSTHSIASENQENRNPGSSGSHAGSNSEQLLPQQSQLAQPQHAI 1250
            ||.|.                             |||            ||..|.|.  ||....
Zfish   695 ISVAL-----------------------------RNP------------QLHRQASH--QPPERH 716

  Fly  1251 VSKPLSAERGIMRGVLTPNSLEK----------NIFRYNDPTV----NGLLQQQQQQQQQQQQQQ 1301
            :|:|..:.       |..|..:.          :|.|...||.    :|:|              
Zfish   717 LSRPAFSR-------LATNDFQSLMMRDLNSSIDISRLPSPTAGLSGSGVL-------------- 760

  Fly  1302 QQHQQLQQHGHQQQPHHQHPLQMLSNSQTSIAGNQ---YMSSPGGLQHAQSQTSMASSSLNGSSS 1363
                             .|| .|.:.|:....||:   |::.|        ..:.:|.:...|||
Zfish   761 -----------------SHP-GMAAFSERDPRGNKDVFYVTRP--------PLARSSPAYCTSSS 799

  Fly  1364 NLLHGHQQHAHHPQQLHPHHCPPAPQT-SASSTMERMD----RMNYPYMSHNGNDYETSTPSSTR 1423
            ::..                  |.|:. |.:.::..||    |:|.....|:.||...|:..|..
Zfish   800 DITE------------------PDPKVLSVNKSVSMMDLQDSRINSVSNLHSVNDLLNSSQGSLA 846

  Fly  1424 SRTLPRNGNP-NANGNV--GSSNNNQSG----SYDDMHGEFQIQISGFDTSSAFVCKSPTPMMKS 1481
            ... |..|.| .|.|.|  ||..::.||    :.|.:..:.|        .:|.....|......
Zfish   847 GFG-PLGGAPLRAGGRVSAGSGGSSMSGGLRLTTDSLSQQQQ--------QAAAAMHVPLSFQNP 902

  Fly  1482 SLGPAGAGRSHH----------------------KLNLGIPD--HSGGYVRGNNLN----PNSNM 1518
            ....|..|..:|                      .:..|:|.  || |:.|..:|:    .||.:
Zfish   903 LFHLASDGPQYHTPPHGPTAVPPPLLLAPEPENGHVGFGVPTFAHS-GFSRSEDLSALRTQNSLV 966

  Fly  1519 PKNLEDLDDLFKYAEEHDVAEPANHHNHNQGQQNHQGHLKPAAVPGKEQLSAKSSHCSSGYQSIS 1583
            ..|:............|:.|:.|......|.|:|.|          ::.|...:...::|..:.:
Zfish   967 QPNIVHSHSYSDDFTRHNQADYARRQLSLQVQENLQ----------QQVLMGMTPQTATGTGTPA 1021

  Fly  1584 TNPSPSQSSSPVESQLKAAMGSHNAPLAFKNPSYQLQPQTGSSRSSAQSNTHQQQQQQQQQQFGS 1648
            :..:|..:..||.   :|:|.......|...|::||      |.|||.::|..:.:.|       
Zfish  1022 SLATPPTTIHPVR---QASMAPPPPQRAKPQPAHQL------SVSSAVNSTPPKTRPQ------- 1070

  Fly  1649 RLKPIGGGLVAARAAFLNSGGALEAATLTPSSS-------DEQLSADNYFSYAAAAAAGAGIATK 1706
                              ||..|:    :|.||       .:|||..:  |.|......:..|::
Zfish  1071 ------------------SGNLLQ----SPESSFGGRQLTRQQLSVKD--SPAPGLPHQSSNASE 1111

  Fly  1707 LEAQRSLSGGSSSSTSASASTSNLGKSGGSSAYGRLNGPLKREDVYGSGYGGSSGNVGYGLSTSS 1771
            ..|.:|.:..|:.:|..:.|..|..:|.....       ||..   |:..|..|.:.   |:.:|
Zfish  1112 NPAPQSAANESTENTPTNQSAKNTQQSNQQHL-------LKPS---GNKQGSKSPST---LNPTS 1163

  Fly  1772 AAGHH------QHPHQQQQ-NPMQQQQQRERDQEHKQYAGSVAGSVGSATSAAQRRLSLDSARTL 1829
            ||...      ..||.... ..::..::..:.:||.:                    |:|.:|. 
Zfish  1164 AASERTVAWVSNMPHLSADIESLRVDREEFKLKEHSK--------------------SMDESRL- 1207

  Fly  1830 SDSSTDTEGHCNQLQEG--KRRRQLRSSGGSGGGGAGSEQGLGKSYDQNGEIQLLQQTLDTLCHT 1892
             |...:.|...|.|:|.  ...|:|..          .|:.|.....|..:|.|..|:      .
Zfish  1208 -DRVREYEEEINSLKERLMMSHRKLEE----------YERRLHSQEQQTSKILLQYQS------R 1255

  Fly  1893 LDRDEAELRDSSDELFGLQRPAGSNGSNNLSLQSESTMRSIIDSFFQSSCRLITMEEELRREQLK 1957
            ||..|..||..                   .::.:|.::.||:       ||:.:|:|||...:.
Zfish  1256 LDDSERRLRQQ-------------------QVEKDSQIKGIIN-------RLMAVEDELRGSGMP 1294

  Fly  1958 MSLALSHKQRVIEEQ 1972
                 ..|.|:..||
Zfish  1295 -----DLKTRIFTEQ 1304

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
raskolNP_001285388.1 PH_RasSynGAP-like 615..729 CDD:270082 42/132 (32%)
PH <656..720 CDD:278594 21/63 (33%)
C2_SynGAP_like 721..874 CDD:175980 71/152 (47%)
RasGAP 856..1185 CDD:214617 153/338 (45%)
RasGAP_DAB2IP 865..1192 CDD:213338 153/336 (46%)
syngap1aXP_005159373.1 PH-like 108..299 CDD:302622 76/191 (40%)
C2_SynGAP_like 241..386 CDD:175980 71/152 (47%)
RasGAP 366..694 CDD:214617 154/340 (45%)
RasGAP_DAB2IP 377..702 CDD:213338 154/366 (42%)
DUF3498 692..1289 CDD:288827 158/841 (19%)
GrpE 1173..>1288 CDD:295646 31/178 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170577564
Domainoid 1 1.000 133 1.000 Domainoid score I5006
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 552 1.000 Inparanoid score I1093
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D44624at33208
OrthoFinder 1 1.000 - - FOG0000844
OrthoInspector 1 1.000 - - otm24616
orthoMCL 1 0.900 - - OOG6_102644
Panther 1 1.100 - - O PTHR10194
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X495
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1211.900

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