DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment raskol and dab2ipa

DIOPT Version :9

Sequence 1:	NP_001285388.1	Gene:	raskol / 32754	FlyBaseID:	FBgn0261570	Length:	2016	Species:	Drosophila melanogaster
Sequence 2:	XP_017212908.1	Gene:	dab2ipa / 100002454	ZFINID:	ZDB-GENE-081104-516	Length:	1256	Species:	Danio rerio

Alignment Length:	1638	Identity:	442/1638 - (26%)
Similarity:	646/1638 - (39%)	Gaps:	546/1638 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   484 HQGVMQ-------GALSISCAGDNSSNNGSWGKHF----------YQPYDVCPLSLDELNCYFQA 531
            |||.|:       ....:|| |...|....|...|          ....::.||...|.    :|
Zfish    17 HQGWMRVTDMKGSSVHWLSC-GQPLSEPIGWQVKFCLVAECQLVLLDKREISPLLFQER----RA 76

  Fly   532 DQCEKLICERFKIRDLAIHMASASAIGADLSVTTENETTATADDDAGHHSDTSYEKACRRGSAPT 596
            :.|...:..|      :..:.....:..|.|..|.| |.:.||            :..||.|.|
Zfish    77 ESCTVWLLRR------STSIPEGVQLRKDQSTQTRN-TKSLAD------------RVGRRRSMP- 121

  Fly   597 TPILGSKQHQT------EHNATSRFTNFFSKK-SNPLKRTKSVTKLERTKRGSGGLRG------- 647
                ||...:|      :.:...:.|.|.|:: ...:|||||..||:|.......|.|
Zfish   122 ----GSTVDKTVVAMDADTSTPFKVTGFLSRRLKGSIKRTKSQPKLDRHSSFRNILPGFKSAEND 182

  Fly   648 -----------SRSHESLLSSHAVMSTIDLSCTGAVGVAPVHQSVLGRRHCFQVRGGPRGERYYS 701
                       |||||||||..:.:..:|||....|.:.|||.|:||:..||:|... .|.:.:|
Zfish   183 SRSHLMPRLKESRSHESLLSPSSAVEALDLSMEEEVLIKPVHSSILGQDFCFEVTTS-TGSKCFS 246

  Fly   702 CGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLPPKKRYFCELQLDKTLYGRTSVK 766
            |.|..|||.|:.:||:::.||.::|||.:|.||.|:.|||:||.||:|||||.||.|||.||:.|
Zfish   247 CRSAAERDKWMENLRRAVHPNKDNTRRVENMLKCWIIEAKDLPAKKKYFCELCLDDTLYARTTCK 311

  Fly   767 LQTDLLFWGEHFDFPDIPEINVITVNVFREVDKKKKRDKYQFVGSVKIPVHDVTSRLPCEQWYPI 831
            |:||.:||||||:|.::|.:..|||::::|.|||||:||..:||.|.||:..||.|...|:||.:
Zfish   312 LKTDNVFWGEHFEFNNLPSVKSITVHLYKETDKKKKKDKNNYVGLVNIPIATVTGRQFVEKWYSV 376

  Fly   832 LSDKAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTDILPINVYGNFLTYLKENYKRVCETLE 896
            .:.              :.:|.|...|.:|:|.|:||..|||:.:|..|..|:..||..:|..||
Zfish   377 STP--------------NPNKGKSPGPMVRMKSRYQSMSILPMELYKEFAEYITNNYMLMCSVLE 427

  Fly   897 PVIGVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGD-QRLTFRGNSLATKSMEAFLKLT 960
            |.:.||.||::..|||.::.:.|.|..||||::..::.|.|| :.|.||.|:||||::|.:|||.
Zfish   428 PALSVKNKEEMACALVHILQSTGKAKDFLTDLMMSEVDRCGDNEHLIFRENTLATKAIEEYLKLV 492

  Fly   961 GEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAVRGAWQCIFESHKHFPA 1025
            |::||||.|...|..|.:|:.:|||||:|.|.|   .|...|:.|:.....|:..|..|:..||.
Zfish   493 GQKYLQDALGEFIKALYESDENCEVDPSKCSSS---DLHEHQSNLKMCCELAFCKIINSYCVFPR 554

  Fly  1026 QLRNCFATFRERLQQLGRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSARATRNLTLVAK 1090
            :|:..||::|:.....||.|:::.|||||:|||||||||:|||||::..|.|..|..|.|||:||
Zfish   555 ELKEVFASWRQECSSRGRPDISERLISASLFLRFLCPAIMSPSLFSLMQEYPDDRTARTLTLIAK 619

  Fly  1091 TLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEIISTRPEHPAPDSILDWA---GYIDQGK 1152
            ..|.|||||:|..||.:|.|:|.|||.|...||:||..||.      |::|.:.|   ||:|.|:
Zfish   620 VTQNLANFTKFGSKEEYMSFMNQFLEHEWTNMQRFLLEISN------PETISNTAGFEGYVDLGR 678

  Fly  1153 QLSILHSLLSESLAKLPEARQHELDPLQHILDEISRAKEHGMGTALPGGYLPATSSTHSIASENQ 1217
            :||.|||||||::::|.:....:|.||..||.:::.|..:..|..:|       |.|..:.|.:
Zfish   679 ELSSLHSLLSEAVSQLDQTTITKLGPLARILRDVNSALTNPTGAPVP-------SPTERVGSPS- 735

  Fly  1218 ENRNPGSSGSHAGSNSEQLLPQQSQLAQPQHAIVSKPLSAERGIMRGVLTPNSLEKNIFRYNDPT 1282
                               ||..|             ||.  |:.:.|:             |..
Zfish   736 -------------------LPSSS-------------LST--GLQKMVM-------------DSE 753

  Fly  1283 VNGLLQQQQQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQMLSNSQTSIAGNQYMSSPGGLQHA 1347
            :.||:
Zfish   754 ITGLV------------------------------------------------------------ 758

  Fly  1348 QSQTSMASSSLNGSSSNLLHGHQQHAHHPQQLHPHHCPPAPQTSASSTMERMDRMNYPYMSHNGN 1412

Zfish   759 ----------------------------------------------------------------- 758

  Fly  1413 DYETSTPSSTRSRTLPRNGNPNANGNVGSSNNNQSGSYDDMHGEFQIQISGFDTSSAFVCKSPTP 1477
            |: |..||.|     |.|                    .|:.         |.|.::.:  .|:|
Zfish   759 DF-TRLPSPT-----PEN--------------------KDLF---------FVTRNSVI--QPSP 786

  Fly  1478 MMKSSLGPAGAGRSHHKLNLGIPDHSGGYVRGNNLNPNSNMPKNLEDLDD--LFKYAEEHDVAEP 1540
            ...||...|..           ||..         .||.:...::.||.|  ..:.|.....::|
Zfish   787 ARSSSYSEANE-----------PDVQ---------IPNGSKSLSMVDLQDSRSLESAANTSFSDP 831

  Fly  1541 ANHHNHNQGQQNHQGHLKPAAVPGKEQLSAKSSHCSSG---YQSISTNPSPSQSSSPVESQLKAA 1602
            .|....:.||.  .|......:.|         :..||   .::..|..:||..|:|..|||.
Zfish   832 INDSQASAGQS--AGMWTTRTIKG---------NTPSGPTLRRAGQTPTTPSTESAPGRSQLL-- 883

  Fly  1603 MGSHNAPLAFKNPSYQLQPQTGSSRSSAQSNTHQQQQQQQQQQFGSRLKPIGGGLVAARAAFLNS 1667
                 |||:|:||.||:                                  ..||..:..|..:|
Zfish   884 -----APLSFQNPVYQM----------------------------------AAGLPVSPRAVADS 909

  Fly  1668 GGALEAATLTPSSSDEQLSADNYFSYAAAAAAGAGIATKLEAQRSLSGGSSSSTSAS-----AST 1727
            |.                                      |.|.|:|..:..:.:|.     .|.
Zfish   910 GS--------------------------------------ECQSSISSNAEEAATAGPKHPFISQ 936

  Fly  1728 SNLGKSGGSSAYGRLNGPLKREDVYGSGYGGSSGN---------VGYGLSTSSAAGHHQHPHQQQ 1783
            |:.|.|||                     |||||:         ....||.:........|.|..
Zfish   937 SSTGASGG---------------------GGSSGDEFIQRPGEFTRRQLSLTETQHQTNVPRQNS 980

  Fly  1784 QNPMQQQQQRERDQE-------------------HKQYAGSV------------------AGSVG 1811
            ..|     ||..||.                   .:..:||:                  :.|.|
Zfish   981 AGP-----QRRIDQPPPAITRGRTPPNMLNTAPYPRPSSGSMMSSSPDWPSSGTRLRQQSSSSKG 1040

  Fly  1812 SATSAAQRRLSLDSARTLSDSSTDTEG------HCNQL-QEG-----KRRRQLRSSGGSGGGGAG 1864
            .:..:.||.|...:...::.::.|...      :...| |||     |.|...           .
Zfish  1041 DSPESKQRTLHKQAPSPVNPNALDRTAAWLLNMNVQYLEQEGIDPDSKHREDF-----------P 1094

  Fly  1865 SEQGLGKSYDQNGEIQLLQQTLDTLCHTLDRDEAELRDSSDE----LFGLQRPAGSNGSNNLSLQ 1925
            :::.|..:.....||.:||:.|......|:..|:.::...|:    |...|... .:....|..|
Zfish  1095 NKEDLTPTEKYQHEIAVLQEKLRISAKKLEEYESRMKSQDDQTQKMLLEYQARL-EDTEERLRKQ 1158

  Fly  1926 ---SESTMRSIIDSFFQSSCRLITMEEELRREQLKMSLALSHKQRVIEEQGQQIAALDAANSRLL 1987
               .|..|:|||       .||:::||||:::...|...:..||::||.|.::||:|||||:||:
Zfish  1159 QDDKELQMKSII-------TRLMSVEEELKKDHSDMQAIVDSKQKIIEAQEKRIASLDAANARLM 1216

  Fly  1988 SALTALRQRYETQ 2000
            |||:.|:.||..|
Zfish  1217 SALSQLKDRYSMQ 1229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	49/132 (37%)
		PH	<656..720	CDD:278594	24/63 (38%)
		C2_SynGAP_like	721..874	CDD:175980	72/152 (47%)
		RasGAP	856..1185	CDD:214617	150/332 (45%)
		RasGAP_DAB2IP	865..1192	CDD:213338	148/330 (45%)
dab2ipa	XP_017212908.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577556
Domainoid	1	1.000	133	1.000	Domainoid score	I5006
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	552	1.000	Inparanoid score	I1093
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D44624at33208
OrthoFinder	1	1.000	-	-		FOG0000844
OrthoInspector	1	1.000	-	-		otm24616
orthoMCL	1	0.900	-	-		OOG6_102644
Panther	1	1.100	-	-	O	PTHR10194
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2053
SonicParanoid	1	1.000	-	-		X495
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.930