DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8173 and RIPK1

DIOPT Version :9

Sequence 1:	NP_573239.1	Gene:	CG8173 / 32753	FlyBaseID:	FBgn0030864	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_001341859.1	Gene:	RIPK1 / 8737	HGNCID:	10019	Length:	671	Species:	Homo sapiens

Alignment Length:	291	Identity:	70/291 - (24%)
Similarity:	136/291 - (46%)	Gaps:	48/291 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 TQNMRVKKDTLF--------NERIVHEADILRKLKHPNIVGFRGVITNDEGINTLALEMCTTSLG 120
            ||.:.:.| |::        ||.::.||.::.:|:|..:|...|||. :||..:|.:|.  ...|
Human    38 TQGLMIMK-TVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVII-EEGKYSLVMEY--MEKG 98

  Fly   121 SILEERHDEDLGPLPAKHTYKMIMDVAQALDFLHNEAHLMHGDLKSFNVLVKGEFEICKLCDFGV 185
            :::.....|...||..|.  ::|:::.:.:.:||.:. ::|.|||..|:||..:|.| |:.|.|:
Human    99 NLMHVLKAEMSTPLSVKG--RIILEIIEGMCYLHGKG-VIHKDLKPENILVDNDFHI-KIADLGL 159

  Fly   186 S-------LPLDEQGEVNFLKNPGLRYVGTNLWCAPEVIDEVDVIDS-KADIFSFGLVIYETLAL 242
            :       |..:|..|:..:.....:..||..:.|||.:::|:...: |:|::||.:|::...|.
Human   160 ASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFAN 224

  Fly   243 VPPHTLELDAALGEDM--------------DSSHDLPTDTDKLQ--CKQLDFSSDENKNGLPSAM 291
            ..|:    :.|:.|..              |.:...|.:...|.  |.:   ::.|.:...|...
Human   225 KEPY----ENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWE---ANPEARPTFPGIE 282

  Fly   292 EEHTDNDMSQDYDEEDDEEEKEEEEEDDEED 322
            |:.....:|| .:|..:|:.|..::|...|:
Human   283 EKFRPFYLSQ-LEESVEEDVKSLKKEYSNEN 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8173	NP_573239.1	PKc_like	28..389	CDD:304357	70/291 (24%)
CG8173	NP_573239.1	S_TKc	30..>245	CDD:214567	53/196 (27%)
RIPK1	NP_001341859.1	STKc_RIP1	23..290	CDD:270929	63/266 (24%)
		Interaction with SQSTM1. /evidence=ECO:0000269\|PubMed:10356400	290..582		7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	331..354
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..458
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:11734559, ECO:0000269\|PubMed:29681455	531..547
		Death_RIP1	583..668	CDD:260048
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900