DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8173 and tnni3k

DIOPT Version :9

Sequence 1:	NP_573239.1	Gene:	CG8173 / 32753	FlyBaseID:	FBgn0030864	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_001191752.1	Gene:	tnni3k / 799621	ZFINID:	ZDB-GENE-081104-399	Length:	835	Species:	Danio rerio

Alignment Length:	266	Identity:	82/266 - (30%)
Similarity:	116/266 - (43%)	Gaps:	46/266 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 NLHLENVQNSSTPINVPPSPMMKTLGHGTGIRVYRLDRSPRLGEIRSP-WAVKRITQNMRV-KKD 72
            |.||   |.|....|       :.:|.|:..:||:       |:.|:. .|:||...|... |.|
Zfish   455 NFHL---QLSELEFN-------EIIGSGSFGKVYK-------GKCRNKIVAIKRYRPNTYCSKSD 502

  Fly    73 TLFNERIVHEADILRKLKHPNIVGFRGVITNDEGINTLALEMCTTSLGSILEERHDE----DLGP 133
            |   :....|..||.:|.||.::.|.|...:|.  :..|:.....|.||:....|::    ||
Zfish   503 T---DMFCREVSILCRLNHPCVIQFVGACLDDP--SQFAIVTQYVSGGSLFSLLHEQKRIIDL-- 560

  Fly   134 LPAKHTYKMI--MDVAQALDFLHNEAH-LMHGDLKSFNVLVKGEFEICKLCDFGVSLPLDEQGEV 195
                 ..|:|  :|||:.:::|||... ::|.||.|.|:|:. |.....:.|||.|..|....|.
Zfish   561 -----QSKLIIAIDVAKGMEYLHNLTQPIIHRDLNSHNILLY-EDGHAVVADFGESRFLLSVDED 619

  Fly   196 NFLKNPGLRYVGTNL-WCAPEVIDEVDVIDSKADIFSFGLVIYETLALVPPHTLELDAALGEDMD 259
            |..|.||      || |.||||..:......|||:||:.|.::|.|....|......||...||.
Zfish   620 NMTKQPG------NLRWMAPEVFTQCTRYTVKADMFSYALCLWELLTGEIPFAHLKPAAAAADMA 678

  Fly   260 SSHDLP 265
            ..|..|
Zfish   679 YHHVRP 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8173	NP_573239.1	PKc_like	28..389	CDD:304357	76/248 (31%)
CG8173	NP_573239.1	S_TKc	30..>245	CDD:214567	69/224 (31%)
tnni3k	NP_001191752.1	ANK	<56..121	CDD:238125
		Ank_4	67..121	CDD:290365
		ANK repeat	67..98	CDD:293786
		ANK	99..220	CDD:238125
		ANK repeat	100..131	CDD:293786
		Ank_2	105..195	CDD:289560
		ANK repeat	136..164	CDD:293786
		ANK	161..290	CDD:238125
		ANK repeat	166..197	CDD:293786
		Ank_2	171..261	CDD:289560
		ANK repeat	199..232	CDD:293786
		ANK	229..360	CDD:238125
		ANK repeat	269..302	CDD:293786
		Ank_2	274..369	CDD:289560
		ANK repeat	304..337	CDD:293786
		ANK	334..>401	CDD:238125
		ANK repeat	339..369	CDD:293786
		Ank_2	344..>411	CDD:289560
		TyrKc	463..719	CDD:197581	77/255 (30%)
		PKc_TNNI3K	469..722	CDD:270966	76/242 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900