DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8173 and LRRK1

DIOPT Version :9

Sequence 1:	NP_573239.1	Gene:	CG8173 / 32753	FlyBaseID:	FBgn0030864	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_078928.3	Gene:	LRRK1 / 79705	HGNCID:	18608	Length:	2015	Species:	Homo sapiens

Alignment Length:	291	Identity:	86/291 - (29%)
Similarity:	127/291 - (43%)	Gaps:	74/291 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DTPRRK-LRNLHLENVQNSSTPINVPPSPMMKTLGH-GTGIRVYRLDRSPRLGEIRSPWAVKRIT 64
            |.|.|. |.|..||:.::..:           .||. |:|..:||.....:      |.||||
Human  1226 DFPARLFLENSKLEHSEDEGS-----------VLGQGGSGTVIYRARYQGQ------PVAVKR-- 1271

  Fly    65 QNMRVKK---------DTL------------FNERIVHEADILRKLKHPNIVGFRGVITNDEGIN 108
              ..:||         ||:            |:| ...||.:|..|:||.||...|:     .|:
Human  1272 --FHIKKFKNFANVPADTMLRHLRATDAMKNFSE-FRQEASMLHALQHPCIVALIGI-----SIH 1328

  Fly   109 TL--ALEMC-TTSLGSILEER-HDEDLGPLPAKHTYKMIMDVAQALDFLHNEAHLMHGDLKSFNV 169
            .|  |||:. .:||.::|.|. .|....||....|.|:...:|..|.:||.: :::..||||.|:
Human  1329 PLCFALELAPLSSLNTVLSENARDSSFIPLGHMLTQKIAYQIASGLAYLHKK-NIIFCDLKSDNI 1392

  Fly   170 L-----VKGEFEICKLCDFGVSLPLDEQGEVNFLKNPGLRYVGTNLWCAPEVIDEVDVIDSKADI 229
            |     ||....| ||.|:|:|.....:|.:.....||.:        |||:...: |.|.|.|:
Human  1393 LVWSLDVKEHINI-KLSDYGISRQSFHEGALGVEGTPGYQ--------APEIRPRI-VYDEKVDM 1447

  Fly   230 FSFGLVIYETLALVPP----HTLELDAALGE 256
            ||:|:|:||.|:...|    |.|::...|.:
Human  1448 FSYGMVLYELLSGQRPALGHHQLQIAKKLSK 1478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8173	NP_573239.1	PKc_like	28..389	CDD:304357	79/264 (30%)
CG8173	NP_573239.1	S_TKc	30..>245	CDD:214567	75/245 (31%)
LRRK1	NP_078928.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..56
		ANK 1	86..116
		ANK	95..214	CDD:238125
		ANK 2	119..148
		Ank_2	126..221	CDD:289560
		ANK 3	152..182
		ANK repeat	156..186	CDD:293786
		ANK repeat	188..218	CDD:293786
		ANK 4	193..222
		LRR_RI	<214..488	CDD:238064
		LRR 1	279..300
		leucine-rich repeat	281..303	CDD:275380
		LRR	302..614	CDD:227223
		LRR 2	303..324
		leucine-rich repeat	304..330	CDD:275380
		LRR 3	330..351
		leucine-rich repeat	331..353	CDD:275380
		LRR 4	353..374
		leucine-rich repeat	354..381	CDD:275380
		LRR_RI	379..641	CDD:238064
		LRR 5	381..402
		leucine-rich repeat	382..405	CDD:275380
		LRR 6	405..426
		leucine-rich repeat	406..451	CDD:275380
		LRR 7	427..447
		LRR 8	451..472
		leucine-rich repeat	452..474	CDD:275380
		LRR 9	474..495
		leucine-rich repeat	475..498	CDD:275380
		LRR 10	498..519
		leucine-rich repeat	499..549	CDD:275380
		LRR 11	549..570
		leucine-rich repeat	550..572	CDD:275380
		LRR 12	572..594
		LRR 13	596..617
		Gem1	635..>781	CDD:224025
		P-loop_NTPase	639..821	CDD:304359
		COR	844..1036	CDD:292713
		S_TKc	1245..1511	CDD:214567	79/272 (29%)
		STKc_LRRK1	1248..1523	CDD:270969	79/258 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1788..1810
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1841..1899
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900