DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8173 and Ripk4

DIOPT Version :9

Sequence 1:	NP_573239.1	Gene:	CG8173 / 32753	FlyBaseID:	FBgn0030864	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_076152.2	Gene:	Ripk4 / 72388	MGIID:	1919638	Length:	786	Species:	Mus musculus

Alignment Length:	191	Identity:	52/191 - (27%)
Similarity:	87/191 - (45%)	Gaps:	18/191 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 WAVKRITQNMRVKKDTLFNERIVHEADILRKLKHPNIVGFRGVITNDEGINTLALE-MCTTSLGS 121
            |...:.:.::.|  |......::.||..:...|...|:...|:.....|   |.:| |.|.||..
Mouse    47 WLAIKCSPSLHV--DDRERMELLEEAKKMEMAKFRYILPVYGICQEPVG---LVMEYMETGSLEK 106

  Fly   122 ILEERHDEDLGPLPAKHTYKMIMDVAQALDFLH-NEAHLMHGDLKSFNVLVKGEFEICKLCDFGV 185
            :|...      |||....::::.:.|..::||| ....|:|.|||..|:|:...:.: |:.|||:
Mouse   107 LLASE------PLPWDLRFRIVHETAVGMNFLHCMSPPLLHLDLKPANILLDAHYHV-KISDFGL 164

  Fly   186 SLPLDEQGEVNFLKNPGLRYVGTNLWCAPEVIDEVD-VIDSKADIFSFGLVIYETLALVPP 245
            : ..:.....:.|...||  .||..:..||.|.|.. :.|:|.|::||.:||:..|....|
Mouse   165 A-KCNGMSHSHDLSMDGL--FGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKP 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8173	NP_573239.1	PKc_like	28..389	CDD:304357	52/191 (27%)
CG8173	NP_573239.1	S_TKc	30..>245	CDD:214567	51/189 (27%)
Ripk4	NP_076152.2	STKc_RIP4_like	25..290	CDD:270927	52/191 (27%)
		TyrKc	26..279	CDD:197581	52/191 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..328
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..378
		ANK 1	439..468
		ANK repeat	442..470	CDD:293786
		Ank_2	444..536	CDD:289560
		ANK	471..591	CDD:238125
		ANK 2	472..501
		ANK repeat	473..503	CDD:293786
		ANK repeat	505..536	CDD:293786
		ANK 3	505..534
		Ank_2	510..602	CDD:289560
		ANK repeat	538..569	CDD:293786
		ANK 4	538..567
		ANK repeat	571..602	CDD:293786
		ANK 5	571..601
		ANK	600..725	CDD:238125
		ANK repeat	605..636	CDD:293786
		ANK 6	605..634
		Ank_2	610..701	CDD:289560
		ANK repeat	638..669	CDD:293786
		ANK 7	638..667
		ANK repeat	671..701	CDD:293786
		ANK 8	671..700
		Ank_2	676..766	CDD:289560
		ANK 9	704..734
		ANK	731..>766	CDD:238125
		ANK repeat	736..766	CDD:293786
		ANK 10	736..765
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900