DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8173 and MAP3K7

DIOPT Version :9

Sequence 1:	NP_573239.1	Gene:	CG8173 / 32753	FlyBaseID:	FBgn0030864	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_663304.1	Gene:	MAP3K7 / 6885	HGNCID:	6859	Length:	606	Species:	Homo sapiens

Alignment Length:	257	Identity:	68/257 - (26%)
Similarity:	112/257 - (43%)	Gaps:	47/257 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 RSPWAVKRITQNMRVKKDTLFNER--IVHEADILRKLKHPNIVGFRGVITNDEGINTLALEMCTT 117
            ::.|..|    ::.:|:....:||  .:.|...|.::.|||||...|..     :|.:.|.|...
Human    52 KAKWRAK----DVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGAC-----LNPVCLVMEYA 107

  Fly   118 SLGSILEERHDEDLGPLP---AKHTYKMIMDVAQALDFLHN--EAHLMHGDLKSFNVLVKGEFEI 177
            ..||:....|..:  |||   |.|.....:..:|.:.:||:  ...|:|.|||..|:|:.....:
Human   108 EGGSLYNVLHGAE--PLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTV 170

  Fly   178 CKLCDFGVSLPLDEQGEVNFLKNPGLRYVGTNLWCAPEVIDEVDVIDSKADIFSFGLVIYETLAL 242
            .|:||||.:..:    :.:...|.     |:..|.||||. |......|.|:||:|::::|.:..
Human   171 LKICDFGTACDI----QTHMTNNK-----GSAAWMAPEVF-EGSNYSEKCDVFSWGIILWEVITR 225

  Fly   243 VPPHTLELDAALGEDMDSSH---------DLPTDTDKL--QCKQLDFSSDENKNGLPSAMEE 293
            ..|.. |:.......|.:.|         :||...:.|  :|    :|.|.::.  || |||
Human   226 RKPFD-EIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRC----WSKDPSQR--PS-MEE 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8173	NP_573239.1	PKc_like	28..389	CDD:304357	68/257 (26%)
CG8173	NP_573239.1	S_TKc	30..>245	CDD:214567	53/196 (27%)
MAP3K7	NP_663304.1	Interaction with MAPK8IP1. /evidence=ECO:0000250	1..300		68/257 (26%)
		STKc_TAK1	42..292	CDD:270960	68/257 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..338
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..493
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810