DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8173 and MAP3K10

DIOPT Version :9

Sequence 1:	NP_573239.1	Gene:	CG8173 / 32753	FlyBaseID:	FBgn0030864	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	XP_011525283.1	Gene:	MAP3K10 / 4294	HGNCID:	6849	Length:	962	Species:	Homo sapiens

Alignment Length:	335	Identity:	84/335 - (25%)
Similarity:	143/335 - (42%)	Gaps:	72/335 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LGHGTGIRVYR-LDRSPRLGEIRSPWAVKRITQNMRVKKD-TLFNERIVHEADILRKLKHPNIVG 96
            :|.|...:||| |.|...:       |||  ...:..:|| .:..|::..||.:...|:||||:.
Human   104 IGVGGFGKVYRALWRGEEV-------AVK--AARLDPEKDPAVTAEQVCQEARLFGALQHPNIIA 159

  Fly    97 FRGVITNDEGINTLALEMCT-TSLGSILEERHDEDLGPLPAKHTYKMIMDVAQALDFLHNEA--H 158
            .||...|...: .|.:|... .:|..:|..|.      :|........:.||:.:::|||:|  .
Human   160 LRGACLNPPHL-CLVMEYARGGALSRVLAGRR------VPPHVLVNWAVQVARGMNYLHNDAPVP 217

  Fly   159 LMHGDLKSFNVLVKGEFE-------ICKLCDFGVSLPLDEQGEVNFLKNPGLRYVGTNLWCAPEV 216
            ::|.||||.|:|:....|       :.|:.|||::.        .:.|...:...||..|.||||
Human   218 IIHRDLKSINILILEAIENHNLADTVLKITDFGLAR--------EWHKTTKMSAAGTYAWMAPEV 274

  Fly   217 IDEVDVIDSKADIFSFGLVIYETLALVPPHTLELDA---ALGEDMDS-SHDLPTDTDKLQCKQLD 277
            | .:.:....:|::|||::::|.|....|:. |:||   |.|..|:. :..:|:...:...:.|:
Human   275 I-RLSLFSKSSDVWSFGVLLWELLTGEVPYR-EIDALAVAYGVAMNKLTLPIPSTCPEPFARLLE 337

  Fly   278 FSS--------DENKNGLPS-----------------AMEEHTDNDMSQDYDEE-----DDEEEK 312
            ...        |.:.:|.|.                 .|...:.:.:.:|:..|     ||...|
Human   338 GEPGPRDEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTK 402

  Fly   313 EEEEEDDEED 322
            |:|....||:
Human   403 EKELRSREEE 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8173	NP_573239.1	PKc_like	28..389	CDD:304357	84/335 (25%)
CG8173	NP_573239.1	S_TKc	30..>245	CDD:214567	62/222 (28%)
MAP3K10	XP_011525283.1	SH3_MLK1-3	20..76	CDD:212992
		TyrKc	98..365	CDD:197581	74/286 (26%)
		PKc_like	103..368	CDD:304357	74/289 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810