DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8173 and pbk

DIOPT Version :9

Sequence 1:	NP_573239.1	Gene:	CG8173 / 32753	FlyBaseID:	FBgn0030864	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_001002387.1	Gene:	pbk / 360218	ZFINID:	ZDB-GENE-030523-2	Length:	339	Species:	Danio rerio

Alignment Length:	375	Identity:	133/375 - (35%)
Similarity:	190/375 - (50%)	Gaps:	74/375 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VQNSSTPINVPPSPMMKTLGHGTGIRVYRLDRSPRLGEIRSPWAVKRITQNMRVKKDTLFNERIV 80
            |....||:.:|.||.||.||.|||:.||.::|..:  :..||||:|:|.......:.:::.:|:.
Zfish    24 VNACGTPVTIPASPFMKKLGCGTGVNVYLMNRMGK--QTHSPWAIKKINSKCAQGQVSVYQKRLC 86

  Fly    81 HEADILRKLKHPNIVGFRGVITNDEGINTLALEM-CTTSLGSILEERHDEDLGPLPAKHTYKMIM 144
            .||.||:.||||||||||...|..:|...||:|. ...||..::|:|.:|.|...|.....|:.:
Zfish    87 EEAKILKDLKHPNIVGFRAFTTAKDGSKCLAMEFGGEQSLNDLIEKRREEGLQAFPVDTIEKVAL 151

  Fly   145 DVAQALDFLHNEAHLMHGDLKSFNVLVKGEFEICKLCDFGVSLPLDEQGEVNFLKNPGLRYVGTN 209
            .||:.|.:||||..|:|||:||.||::||:||..|:||.||||||||..:|:   :|...|:||.
Zfish   152 HVARGLLYLHNEKKLLHGDMKSCNVVIKGDFESIKICDVGVSLPLDENMQVS---DPKAHYIGTE 213

  Fly   210 LWCAPEVIDEVDVIDSKADIFSFGLVIYETLALVPPHTLELDAALGEDMDSSHDLPTDTDKLQCK 274
            .|...|.::: .||..|||||::||.::|.:.|..||...||.
Zfish   214 PWKPKEALED-GVITDKADIFAYGLTLWEMMTLSVPHLEMLDT---------------------- 255

  Fly   275 QLDFSSDENKNGLPSAMEEHTDNDMSQDYDEEDDEEEKEEEEEDDEEDDDTKENDISYFTLNNLH 339
                                       :.||:||:|..||:.::|           :|:
Zfish   256 ---------------------------EGDEDDDDESFEEDFDED-----------AYY------ 276

  Fly   340 SAYGTRPPLPVAFQLSDDYNCVVELFYLCTNALSEDRPAAKTIWQCLENN 389
            ...|:||.|. |..|...|..:||||.|||....:.||:|..|.|.||:|
Zfish   277 ERLGSRPALD-AVTLGGSYQRMVELFCLCTEEDPQKRPSAAHIVQVLESN 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8173	NP_573239.1	PKc_like	28..389	CDD:304357	128/361 (35%)
CG8173	NP_573239.1	S_TKc	30..>245	CDD:214567	92/215 (43%)
pbk	NP_001002387.1	PKc_TOPK	36..325	CDD:270903	128/361 (35%)
pbk	NP_001002387.1	Pkinase_Tyr	38..322	CDD:285015	124/356 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596809
Domainoid	1	1.000	175	1.000	Domainoid score	I3609
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32415
Inparanoid	1	1.050	207	1.000	Inparanoid score	I3684
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1093418at2759
OrthoFinder	1	1.000	-	-		FOG0007348
OrthoInspector	1	1.000	-	-		oto40252
orthoMCL	1	0.900	-	-		OOG6_110471
Panther	1	1.100	-	-	LDO	PTHR43289
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5709
SonicParanoid	1	1.000	-	-		X5468
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790