DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8173 and Lrrk1

DIOPT Version :9

Sequence 1:	NP_573239.1	Gene:	CG8173 / 32753	FlyBaseID:	FBgn0030864	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_001178553.1	Gene:	Lrrk1 / 308703	RGDID:	1308000	Length:	2013	Species:	Rattus norvegicus

Alignment Length:	284	Identity:	82/284 - (28%)
Similarity:	123/284 - (43%)	Gaps:	72/284 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DTPRRK-LRNLHLENVQNSSTPINVPPSPMMKTLGH-GTGIRVYRLDRSPRLGEIRSPWAVKRIT 64
            |.|.|. |.|..||:.:..::           .||. |:|..:|:.....:      |.||||
  Rat  1226 DFPARLFLENSKLEHTEGENS-----------ILGQGGSGTVIYQAQYQGQ------PVAVKR-- 1271

  Fly    65 QNMRVKK---------DTL------------FNERIVHEADILRKLKHPNIVGFRGVITNDEGIN 108
              ..:||         ||:            |:: ...||.:|..|:||.||...|:     .|:
  Rat  1272 --FHIKKFKNSANAPADTMLRHLRAMDAMKNFSD-FRQEASMLHALQHPCIVSLIGI-----SIH 1328

  Fly   109 TL--ALEMCTT-SLGSILEER-HDEDLGPLPAKHTYKMIMDVAQALDFLHNEAHLMHGDLKSFNV 169
            .|  |||:... ||.::|.|. .|....||....|.|:...:|..|.:||.: :::..||||.|:
  Rat  1329 PLCFALELAPLGSLNTVLSENAKDSSFMPLGHMLTQKIAYQIASGLAYLHKK-NIIFCDLKSDNI 1392

  Fly   170 LVKG----EFEICKLCDFGVSLPLDEQGEVNFLKNPGLRYVGTNLWCAPEVIDEVDVIDSKADIF 230
            ||..    |....||.|:|:|.....:|.:.....||.:        |||:...: |.|.|.|:|
  Rat  1393 LVWSLSVKELINIKLSDYGISRQSFHEGALGVEGTPGYQ--------APEIRPRI-VYDEKVDMF 1448

  Fly   231 SFGLVIYETLALVPP----HTLEL 250
            |:|:|:||.|:...|    |.|::
  Rat  1449 SYGMVLYELLSGQRPALGHHQLQI 1472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8173	NP_573239.1	PKc_like	28..389	CDD:304357	75/257 (29%)
CG8173	NP_573239.1	S_TKc	30..>245	CDD:214567	72/244 (30%)
Lrrk1	NP_001178553.1	ANK	91..214	CDD:238125
		ANK repeat	91..119	CDD:293786
		Ank_2	126..221	CDD:289560
		ANK repeat	156..186	CDD:293786
		ANK repeat	188..218	CDD:293786
		LRR_RI	<273..464	CDD:238064
		LRR	<279..513	CDD:227223
		leucine-rich repeat	281..303	CDD:275380
		leucine-rich repeat	304..330	CDD:275380
		leucine-rich repeat	331..381	CDD:275380
		leucine-rich repeat	382..405	CDD:275380
		leucine-rich repeat	406..451	CDD:275380
		leucine-rich repeat	452..474	CDD:275380
		leucine-rich repeat	475..498	CDD:275380
		leucine-rich repeat	499..549	CDD:275380
		leucine-rich repeat	550..572	CDD:275380
		Gem1	635..>781	CDD:224025
		P-loop_NTPase	639..821	CDD:304359
		COR	844..1036	CDD:292713
		S_TKc	1247..1511	CDD:214567	75/252 (30%)
		STKc_LRRK1	1248..1523	CDD:270969	75/251 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900