DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8173 and Ripk4

DIOPT Version :9

Sequence 1:	NP_573239.1	Gene:	CG8173 / 32753	FlyBaseID:	FBgn0030864	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_001100573.1	Gene:	Ripk4 / 304053	RGDID:	1311691	Length:	786	Species:	Rattus norvegicus

Alignment Length:	297	Identity:	67/297 - (22%)
Similarity:	110/297 - (37%)	Gaps:	78/297 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 WAVKRITQNMRVKKDTLFNERIVHEADILRKLKHPNIVGFRGVITNDEGINTLALE-MCTTSLGS 121
            |...:.:.::.|  |......::.||..:...|...|:...|:.....|   |.:| |.|.||..
  Rat    47 WLAIKCSPSLHV--DDRERTELLEEAKKMEMAKFRYILPVYGICQEPVG---LVMEYMETGSLEK 106

  Fly   122 ILEERHDEDLGPLPAKHTYKMIMDVAQALDFLH-NEAHLMHGDLKSFNVLVKGEFEICKLCDFGV 185
            :|...      |||....::::.:.|..::||| ....|:|.|||..|:|:...:.: |:.|||:
  Rat   107 LLASE------PLPWDLRFRIVHETAVGMNFLHCMSPPLLHLDLKPANILLDAHYHV-KISDFGL 164

  Fly   186 SLPLDEQGEVNFLKNPGLRYVGTNLWCAPEVIDEVD-VIDSKADIFSFGLVIYETLALVPPHTLE 249
            : ..:.....:.|...||  .||..:..||.|.|.. :.|:|.|::||.:||:..|....|
  Rat   165 A-KCNGMSHSHDLSMDGL--FGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKP---- 222

  Fly   250 LDAALGEDMDSSHDLPTDTDKLQCKQLDFSSDEN------------KNGLP-------------- 288
                                        ||.::|            :..||
  Rat   223 ----------------------------FSDEKNILHIMMKVVKGHRPELPPICRPRPRACASLI 259

  Fly   289 SAMEE--HTDNDMSQDYDEEDDEEEKEEEEEDDEEDD 323
            ..|:.  |.|..:...:.|...|.|...|:.|:|..|
  Rat   260 GLMQRCWHADPQVRPTFQEITSETEDLCEKPDEEVKD 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8173	NP_573239.1	PKc_like	28..389	CDD:304357	67/297 (23%)
CG8173	NP_573239.1	S_TKc	30..>245	CDD:214567	51/189 (27%)
Ripk4	NP_001100573.1	STKc_RIP4_like	25..290	CDD:270927	64/289 (22%)
		TyrKc	26..279	CDD:197581	60/278 (22%)
		ANK repeat	442..470	CDD:293786
		Ank_2	444..536	CDD:289560
		ANK	471..591	CDD:238125
		ANK repeat	473..503	CDD:293786
		ANK repeat	505..536	CDD:293786
		ANK repeat	538..569	CDD:293786
		Ank_2	544..634	CDD:289560
		ANK repeat	571..602	CDD:293786
		ANK	600..725	CDD:238125
		ANK repeat	605..636	CDD:293786
		Ank_2	610..701	CDD:289560
		ANK repeat	638..669	CDD:293786
		ANK repeat	671..701	CDD:293786
		Ank_2	676..766	CDD:289560
		ANK	731..>766	CDD:238125
		ANK repeat	736..766	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900