DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8173 and Ripk3

DIOPT Version :9

Sequence 1:	NP_573239.1	Gene:	CG8173 / 32753	FlyBaseID:	FBgn0030864	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_647558.2	Gene:	Ripk3 / 246240	RGDID:	628899	Length:	478	Species:	Rattus norvegicus

Alignment Length:	364	Identity:	85/364 - (23%)
Similarity:	147/364 - (40%)	Gaps:	69/364 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NSSTPINVPPSPMMKTLGH----GTGIRVYRLDRSPRLGEIRSPWAVKRITQNMRVKKDTLFNER 78
            |.::.|::..|..::.||.    |.| .|:|               .:....|:.|....:.:::
  Rat     9 NGASSISLVGSEELENLGFVGKGGFG-AVFR---------------ARHTAWNLDVAVKIVNSKK 57

  Fly    79 IVHEADILRKLKHPNIVGFRGVITNDE-----GINTLALEMCTTSLGSILEERHDEDLGPLPAKH 138
            |..|...:..|:|.|::...||..|.|     |...:...|...||..:|:..     .|.|...
  Rat    58 ISREVKAMVNLRHENVLLLLGVTENLEWDYVYGPALVTGFMENGSLSGLLQPS-----CPRPWPL 117

  Fly   139 TYKMIMDVAQALDFLHN-EAHLMHGDLKSFNVLVKGEFEICKLCDFGVSL--PLDEQGEVNFLKN 200
            ..:::.:|...:.:||: ...|:|.|||..|||:..|.. .||.|||:|.  ...:.|..:..::
  Rat   118 LCRLLEEVVLGMCYLHSLNPSLLHRDLKPSNVLLDPELH-AKLADFGLSTFQGGSQSGSGSGSRD 181

  Fly   201 PGLRYVGTNLWCAPEVIDEVDVIDSKADIFSFGLVIYETLA-----------LV----------P 244
            .|    ||..:.|||::|........:|::|||::::..||           |:          |
  Rat   182 SG----GTLAYLAPELLDNDGKASKASDVYSFGVLVWTVLAGREAEVVDKTSLIRGAVCNRQRRP 242

  Fly   245 PHT-LELDAALGEDMDSSHDLPTDTDKLQCK-QLDFSSDENK-NGLPSAMEEHTDNDMSQ----- 301
            |.| |..|:.....::...:|.|.....:.| :..|...|:| |.:...:::..|..:|:
  Rat   243 PLTELPPDSPETPGLEGLKELMTHCWSSEPKDRPSFQDCESKTNNVYILVQDKVDAAVSKVKHYL 307

  Fly   302 -DYDEEDDEEEKEEEEEDDEEDDDTKENDISYFTLNNLH 339
             .|...|.:....|..:...|.|..:|. |.|..|:.||
  Rat   308 SQYRSSDTKLSARESSQKGTEVDCPRET-IVYEMLDRLH 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8173	NP_573239.1	PKc_like	28..389	CDD:304357	83/354 (23%)
CG8173	NP_573239.1	S_TKc	30..>245	CDD:214567	57/247 (23%)
Ripk3	NP_647558.2	PKc_like	28..285	CDD:419665	65/282 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..330		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..429
		RHIM	408..458	CDD:403811
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000250\|UniProtKB:Q9Y572	437..461
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900