DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8173 and Map3k21

DIOPT Version :9

Sequence 1:	NP_573239.1	Gene:	CG8173 / 32753	FlyBaseID:	FBgn0030864	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_663583.2	Gene:	Map3k21 / 234878	MGIID:	2385307	Length:	1002	Species:	Mus musculus

Alignment Length:	437	Identity:	94/437 - (21%)
Similarity:	155/437 - (35%)	Gaps:	129/437 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PINVPPSP------------MMKTLGHGTGIRVYRLDRSPRLGEIRSPW-----AVKRITQNMRV 69
            |...||.|            :.:.:|.|...:||           |:.|     |||...::..
Mouse    92 PAPPPPRPCSPVHVDFERLELKELIGAGGFGQVY-----------RATWQGQEVAVKAARRDPE- 144

  Fly    70 KKDTLFNERIVHEADILRKLKHPNIVGFRGVITNDEGINTLALEMCT-TSLGSILEERHDEDLGP 133
            :......|.:..||.:...|:||||:..|||......: .|.||... .:|...|.....:...|
Mouse   145 QDAAAAAESVRREARLFAMLRHPNIIQLRGVCLRQPHL-CLVLEFARGGALNRALAAAASDPRAP 208

  Fly   134 -------LPAKHTYKMIMDVAQALDFLHNEA--HLMHGDLKSFNVLVKGEFE---IC----KLCD 182
                   :|.:......:.:|:.:.:||.||  .::|.||||.|:|:..:.|   ||    |:.|
Mouse   209 GPRRARRIPPQVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITD 273

  Fly   183 FGVSLPLDEQGEVNFLKNPGLRYVGTNLWCAPEVIDEVDVIDSKADIFSFGLVIYETL------- 240
            ||::.        .:.:...:...||..|.||||| ...:....:||:|:|::::|.|
Mouse   274 FGLAR--------EWHRTTRMSAAGTYAWMAPEVI-RSSLFSKGSDIWSYGVLLWELLTGEVPYR 329

  Fly   241 ----------------------------------------------ALVPPHTLELDAALGEDM- 258
                                                          ||:......::.|:..:|
Mouse   330 GIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILQQLTAIEEAVLTNMP 394

  Fly   259 -DSSHDLPTDTDKLQCKQLDFSSDENKNGLPSAMEEHTDNDMSQDYDEEDDEEEKEEEEEDDEED 322
             :|.|.:..|. ||:.:|: ||....|.....:.||.......|...:|.....:|::..:.|.|
Mouse   395 QESFHSMQEDW-KLEIQQM-FSELRTKEKELRSREEELSRAALQQKSQELLLRRREQQLAEREID 457

  Fly   323 DDTKENDISYFTLN----------------NLHSAYGTRPPLPVAFQ 353
            ...:|.::..|.|:                .|....|.|..||..||
Mouse   458 VLERELNVLIFQLSQEAPHVKKRKGRFRRGRLRLKDGHRISLPSDFQ 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8173	NP_573239.1	PKc_like	28..389	CDD:304357	91/431 (21%)
CG8173	NP_573239.1	S_TKc	30..>245	CDD:214567	62/289 (21%)
Map3k21	NP_663583.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		SH3	28..82	CDD:302595
		TyrKc	110..382	CDD:197581	62/293 (21%)
		PKc_like	115..385	CDD:304357	62/291 (21%)
		Leucine-zipper 1	409..430		6/21 (29%)
		Leucine-zipper 2	444..466		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..531
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..604
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..689
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	721..778
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	797..823
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	878..899
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900