DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8173 and Lrrk1

DIOPT Version :9

Sequence 1:	NP_573239.1	Gene:	CG8173 / 32753	FlyBaseID:	FBgn0030864	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	XP_006540901.1	Gene:	Lrrk1 / 233328	MGIID:	2142227	Length:	2015	Species:	Mus musculus

Alignment Length:	285	Identity:	83/285 - (29%)
Similarity:	124/285 - (43%)	Gaps:	74/285 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DTPRRK-LRNLHLENVQNSSTPINVPPSPMMKTLGH-GTGIRVYRLDRSPRLGEIRSPWAVKRIT 64
            |.|.|. |.|..||:.:..::           .||. |:|..:|:.....:      |.||||
Mouse  1227 DFPARLFLENSKLEHTEGENS-----------ILGQGGSGTVIYQARYQGQ------PVAVKR-- 1272

  Fly    65 QNMRVKK---------DTL------------FNERIVHEADILRKLKHPNIVGFRGVITNDEGIN 108
              ..:||         ||:            |:: ...||.:|..|:||.||...|:     .|:
Mouse  1273 --FHIKKFKNSANAPADTMLRHLRAMDAMKNFSD-FRQEASMLHALQHPCIVSLIGI-----SIH 1329

  Fly   109 TL--ALEMCTT-SLGSILEER-HDEDLGPLPAKHTYKMIMDVAQALDFLHNEAHLMHGDLKSFNV 169
            .|  |||:... ||.::|.|. .|....||....|.|:...:|..|.:||.: :::..||||.|:
Mouse  1330 PLCFALELAPLGSLNTVLSENAKDSSFMPLGHMLTQKIAYQIASGLAYLHKK-NIIFCDLKSDNI 1393

  Fly   170 LV-----KGEFEICKLCDFGVSLPLDEQGEVNFLKNPGLRYVGTNLWCAPEVIDEVDVIDSKADI 229
            ||     |....| ||.|:|:|.....:|.:.....||.:        |||:...: |.|.|.|:
Mouse  1394 LVWSLSAKEHINI-KLSDYGISRQSFHEGALGVEGTPGYQ--------APEIRPRI-VYDEKVDM 1448

  Fly   230 FSFGLVIYETLALVPP----HTLEL 250
            ||:|:|:||.|:...|    |.|::
Mouse  1449 FSYGMVLYELLSGQRPALGHHQLQI 1473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8173	NP_573239.1	PKc_like	28..389	CDD:304357	76/258 (29%)
CG8173	NP_573239.1	S_TKc	30..>245	CDD:214567	73/245 (30%)
Lrrk1	XP_006540901.1	Ank_2	59..143	CDD:372319
		ANK repeat	92..120	CDD:293786
		Ank_2	127..219	CDD:372319
		ANK repeat	149..187	CDD:293786
		ANK repeat	189..219	CDD:293786
		LRR	<280..514	CDD:227223
		leucine-rich repeat	282..304	CDD:275380
		leucine-rich repeat	305..331	CDD:275380
		leucine-rich repeat	332..382	CDD:275380
		leucine-rich repeat	355..378	CDD:275380
		leucine-rich repeat	383..406	CDD:275380
		leucine-rich repeat	407..452	CDD:275380
		leucine-rich repeat	453..475	CDD:275380
		leucine-rich repeat	476..499	CDD:275380
		leucine-rich repeat	500..550	CDD:275380
		leucine-rich repeat	551..573	CDD:275380
		P-loop_NTPase	640..822	CDD:393306
		COR	845..1037	CDD:379765
		STKc_LRRK1	1249..1524	CDD:270969	76/252 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900