DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8173 and Ripk1

DIOPT Version :9

Sequence 1:	NP_573239.1	Gene:	CG8173 / 32753	FlyBaseID:	FBgn0030864	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_001346926.1	Gene:	Ripk1 / 19766	MGIID:	108212	Length:	656	Species:	Mus musculus

Alignment Length:	186	Identity:	54/186 - (29%)
Similarity:	102/186 - (54%)	Gaps:	26/186 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 FNERIVHEADILRKLKHPNIVGFRGVITNDEGINTLALE-MCTTSLGSILEERHDEDLGPLPAKH 138
            :||.::.|..::.:|:|..:|...|:|. :||..:|.:| |...:|..:|:.:.|.   ||..|.
Mouse    56 YNEVLLEEGKMMHRLRHSRVVKLLGIII-EEGNYSLVMEYMEKGNLMHVLKTQIDV---PLSLKG 116

  Fly   139 TYKMIMDVAQALDFLHNEAHLMHGDLKSFNVLVKGEFEICKLCDFGVSL----------PLDEQG 193
              ::|::..:.:.:||::. ::|.|||..|:||..:|.| |:.|.||:.          ..::|.
Mouse   117 --RIIVEAIEGMCYLHDKG-VIHKDLKPENILVDRDFHI-KIADLGVASFKTWSKLTKEKDNKQK 177

  Fly   194 EVNFL--KNPGLRYVGTNLWCAPEVIDEVDVIDS-KADIFSFGLVIYETLALVPPH 246
            ||:..  ||.|    ||..:.|||.:::::...: |:|::|||:|::...|...|:
Mouse   178 EVSSTTKKNNG----GTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPY 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8173	NP_573239.1	PKc_like	28..389	CDD:304357	54/186 (29%)
CG8173	NP_573239.1	S_TKc	30..>245	CDD:214567	53/183 (29%)
Ripk1	NP_001346926.1	PKc_like	23..291	CDD:419665	54/186 (29%)
		Interaction with SQSTM1. /evidence=ECO:0000250\|UniProtKB:Q13546	291..567
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..373
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..423
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:18442983, ECO:0000269\|PubMed:27819681, ECO:0000269\|PubMed:27819682	520..536
		Death_RIP1	568..653	CDD:260048
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900