Protein Alignment CG8173 and MLKL

DIOPT Version :9

• Sequence 1: NP_573239.1
• Gene: CG8173 / 32753
• FlyBaseID: FBgn0030864
• Length: 398
• Species: Drosophila melanogaster
• Sequence 2: NP_689862.1
• Gene: MLKL / 197259
• HGNCID: 26617
• Length: 471
• Species: Homo sapiens
• Alignment Length: 224
• Identity: 54/224 - (24%)
• Similarity: 103/224 - (45%)
• Gaps: 40/224 - (17%)

  Fly    40 IRVYRLDRSP----RLGEI---------RSPWAVKRITQNMRVKKDTLFNERIVHEADILRKLKH 91
            |:..:|..||    |..|:         |:|.|:| :.:.::.....:..:....|...::|.:.
Human   196 IKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIK-VFKKLQAGSIAIVRQTFNKEIKTMKKFES 259

  Fly    92 PNIVGFRGVITNDEGIN----TLALEMCTT-SLGSILEERHDEDLGPLPAKHTYKMIMDVAQALD 151
            |||:...|:.. ||.:.    ::.:|.|.. :|..:|:...|..||     ....:::..|:.|.
Human   260 PNILRIFGICI-DETVTPPQFSIVMEYCELGTLRELLDREKDLTLG-----KRMVLVLGAARGLY 318

  Fly   152 FL-HNEAHLMHGDLKSFNVLVKGEFEICKLCDFGV-----SLPLDEQGEVNFLKNPGLRYVGTNL 210
            .| |:||..:||.::|.|.||...::: ||..|.:     |:.|....|..       ..|.:..
Human   319 RLHHSEAPELHGKIRSSNFLVTQGYQV-KLAGFELRKTQTSMSLGTTREKT-------DRVKSTA 375

  Fly   211 WCAPEVIDEVDV-IDSKADIFSFGLVIYE 238
            :.:|:.:::|.. .|.|::|:|||:|::|
Human   376 YLSPQELEDVFYQYDVKSEIYSFGIVLWE 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8173	NP_573239.1	PKc_like	28..389	CDD:304357	54/224 (24%)
		S_TKc	30..>245	CDD:214567	54/224 (24%)
MLKL	NP_689862.1	N-terminal bundle and brace (NBB), mediates INSP6 binding. /evidence=ECO:0000269|PubMed:29883610	1..149
		PHA02988	177..469	CDD:165291	54/224 (24%)
		PKc_like	215..466	CDD:304357	48/205 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900