DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8173 and RIPK3

DIOPT Version :9

Sequence 1:	NP_573239.1	Gene:	CG8173 / 32753	FlyBaseID:	FBgn0030864	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_006862.2	Gene:	RIPK3 / 11035	HGNCID:	10021	Length:	518	Species:	Homo sapiens

Alignment Length:	343	Identity:	78/343 - (22%)
Similarity:	127/343 - (37%)	Gaps:	113/343 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 NERIVHEADILRKLKHPNIVGFRGVITNDEGIN----------TLALEMCTTSLGSILEERHDED 130
            ::.|..|...:..|.:..::...|||   |.:|          |..:|  ..||..:|:.:
Human    54 SKAISREVKAMASLDNEFVLRLEGVI---EKVNWDQDPKPALVTKFME--NGSLSGLLQSQ---- 109

  Fly   131 LGPLPAKHTYKMIMDVAQALDFLHNE-AHLMHGDLKSFNVLVKGEFEICKLCDFGVSLPLDEQGE 194
             .|.|.....:::.:|...:.:||:: ..|:|.|||..|||:..|..: ||.|||:|........
Human   110 -CPRPWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHV-KLADFGLSTFQGGSQS 172

  Fly   195 VNFLKNPGLRYVGTNLWCAPEVIDEVDVIDSKA-DIFSFGLVIYETLALVPPHTLELDAALGEDM 258
            ......||    ||..:.|||:...|:...|.| |::|||::::..||             |.::
Human   173 GTGSGEPG----GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLA-------------GREV 220

  Fly   259 DSSHDLPTDTDKLQCKQLDFSSDENKNGLPSAMEEHTDNDMSQDYDEEDDEEEKEEEEEDDEEDD 323
                :|||:      ..|.:.:..|:...||..|
Human   221 ----ELPTE------PSLVYEAVCNRQNRPSLAE------------------------------- 244

  Fly   324 DTKENDISYFTLNNLHSAYGTRPPLPVAFQLSDDYNCVVELFYLCTNALSEDRPA-----AKT-- 381
                                    ||.|...:.....:.||..||.::..:|||:     .||
Human   245 ------------------------LPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDE 285

  Fly   382 IWQCLENN-GANVATESD 398
            ::|.:||| .|.|:|..|
Human   286 VFQMVENNMNAAVSTVKD 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8173	NP_573239.1	PKc_like	28..389	CDD:304357	72/331 (22%)
CG8173	NP_573239.1	S_TKc	30..>245	CDD:214567	49/180 (27%)
RIPK3	NP_006862.2	S_TKc	22..280	CDD:214567	68/318 (21%)
		PKc_like	27..280	CDD:304357	68/318 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..443
		RHIM	419..468	CDD:289491
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:29681455	450..466
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	476..518
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900