DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8173 and ankk1

DIOPT Version :9

Sequence 1:	NP_573239.1	Gene:	CG8173 / 32753	FlyBaseID:	FBgn0030864	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_001124137.1	Gene:	ankk1 / 100170831	ZFINID:	ZDB-GENE-071015-4	Length:	733	Species:	Danio rerio

Alignment Length:	389	Identity:	71/389 - (18%)
Similarity:	145/389 - (37%)	Gaps:	92/389 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RVYRLDRSPRLGEIRSPWAVKRITQNMRVKKDTLFNERIVHEADILRKLKHPNIVGFRGVITNDE 105
            |||::    :|..:|...|:|..|.:.          |.:.|...:.::|...::...|:
Zfish    42 RVYKV----KLKVLRETCALKTTTNDY----------RNIMEISKIGRMKFNYLISIYGI----- 87

  Fly   106 GINTLALEMCTTSLGSILEERHDEDLGPLPAKH------TYKMIMDVAQALDFLHN-EAHLMHGD 163
                     |......::|......|..|.:.|      .::||.::...::|||: :..::|.:
Zfish    88 ---------CKDPPALVMEYMRKGSLDNLLSNHLLMWPKKFQMIHEMTMGMNFLHSMKPPILHLN 143

  Fly   164 LKSFNVLVKGEFEICKLCDFGVSLPLDEQGEVNFLKNPGLRYVGTNLWCAPEVIDE-VDVIDSKA 227
            ||..|:|:.....: |:.|||. :..:...:..|:::  |...|...:..||.:.: .:...:|.
Zfish   144 LKPANILLDDHLHV-KISDFGF-IKWEFSSKTEFIEH--LMARGNINYVPPETLSQNPEPPGTKY 204

  Fly   228 DIFSFGLVIYETLALVPPHT--------LELDAALGEDMDS-SHDLPTDTDKL-----QCKQLD- 277
            |::||.::::|.|.....:.        :.:.:.....::. ..|.|.:.:.:     ||...|
Zfish   205 DVYSFSIIMWEILTQKRSYAGLSMTEILIRVSSGKRPGVEKIPEDKPPECEDMIGVMQQCWNQDS 269

  Fly   278 -----FSSDENKNGLPSAMEEHTDNDMSQDYDEEDDEEEKEEEEEDDEEDDDT------------ 325
                 ||.......:.|.:.:..|....::..:...|:.|:..:..|:....:
Zfish   270 RSRPPFSKTVRLTEVLSEVLKIPDTFSRREIRKRLPEQPKKTADSSDDSSIQSLLVRKDFNSFKK 334

  Fly   326 ---KENDISYFTLNN--LHSAY--GTRPPLPVAFQLSDDYNC------------VVELFY-LCT 369
               ||:....|..||  ||.|.  |.|..:.:...|....||            |:..|| :|:
Zfish   335 VVRKEHVSMLFQDNNSLLHHAVAGGDRESVQMVLNLGASVNCQSVKGYTPLIVAVLHKFYEICS 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8173	NP_573239.1	PKc_like	28..389	CDD:304357	71/389 (18%)
CG8173	NP_573239.1	S_TKc	30..>245	CDD:214567	42/211 (20%)
ankk1	NP_001124137.1	PKc_like	32..289	CDD:304357	50/278 (18%)
		STYKc	33..276	CDD:214568	47/265 (18%)
		ANK repeat	347..378	CDD:293786	10/30 (33%)
		Ank_2	352..443	CDD:289560	12/47 (26%)
		ANK	375..501	CDD:238125	6/24 (25%)
		ANK repeat	381..411	CDD:293786	4/18 (22%)
		ANK repeat	413..444	CDD:293786
		Ank_2	418..511	CDD:289560
		ANK	441..567	CDD:238125
		ANK repeat	446..477	CDD:293786
		ANK repeat	479..511	CDD:293786
		Ank_2	485..576	CDD:289560
		ANK	508..629	CDD:238125
		ANK repeat	513..544	CDD:293786
		ANK repeat	546..576	CDD:293786
		Ank_2	551..641	CDD:289560
		ANK repeat	581..610	CDD:293786
		ANK	607..731	CDD:238125
		ANK repeat	612..643	CDD:293786
		Ank_2	617..709	CDD:289560
		ANK repeat	645..676	CDD:293786
		ANK repeat	678..709	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900