DRSC/TRiP Functional Genomics Resources

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Protein Alignment par-6 and Pard6g

DIOPT Version :9

Sequence 1:NP_573238.1 Gene:par-6 / 32752 FlyBaseID:FBgn0026192 Length:351 Species:Drosophila melanogaster
Sequence 2:NP_444347.3 Gene:Pard6g / 93737 MGIID:2135606 Length:382 Species:Mus musculus


Alignment Length:331 Identity:172/331 - (51%)
Similarity:219/331 - (66%) Gaps:24/331 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 DTNLIEVKSKFDAEFRRWSFKRNEAEQSFDKFASLIEQLHKLTNIQFLILYIDPRDNDLLPINND 80
            |.:.:||||||.|||||:|..|::..: |:.|..|:...|.::|.:..|.|.|.. .||||||||
Mouse    15 DCSAVEVKSKFGAEFRRFSLDRHKPGK-FEDFYQLVVHTHHISNTEVTIGYADVH-GDLLPINND 77

  Fly    81 DNFGRALKTARPLLRVIVQRKDDLNEYS-GFGTMKPRNLIGSILMGHTPVKTKAPSISIPHDFRQ 144
            |||.:|:.:|.|||||.:|::::.:.|| |.||:..:..:...|......:....:||:|||||.
Mouse    78 DNFCKAVSSANPLLRVFIQKREEADHYSFGAGTLSRKKKVLVTLRDDGLRRRPHLNISMPHDFRP 142

  Fly   145 VSAIIDVDIVPETHRRVRLLKHGSDKPLGFYIRDGTSVRVTASGLEKQPGIFISRLVPGGLAEST 209
            ||:||||||:|||||||||.:||.:||||||||||||||||..||||.|||||||:|||||||||
Mouse   143 VSSIIDVDILPETHRRVRLYRHGYEKPLGFYIRDGTSVRVTPHGLEKVPGIFISRMVPGGLAEST 207

  Fly   210 GLLAVNDEVIEVNGIEVAGKTLDQVTDMMVANSSNLIITVKPANQR--TLTSTHRGSFSRNSQLS 272
            |||||||||:|||||||||||||||||||:|||.|||:||||||||  .:.|:.....|.:|..|
Mouse   208 GLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRSSRTSGSSVHSTDS 272

  Fly   273 SGSHHT----NNTNTSDEIEHDDQDDIVDLTGVTLDESP---------------TSTSAGNHNHQ 318
            :.|||:    :....|:::|.|::.|||....:.....|               ||.:.|.|...
Mouse   273 TTSHHSLPGAHVLQNSEDVESDEEADIVIEGALEPQHIPKTQAVPPGSLSRANGTSLAHGLHRRD 337

  Fly   319 PPLSSS 324
            ..|.||
Mouse   338 MSLHSS 343

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
par-6NP_573238.1 PB1_Par6 20..101 CDD:99724 40/80 (50%)
PDZ_signaling 159..250 CDD:238492 78/90 (87%)
Pard6gNP_444347.3 Interaction with PRKCI and PRKCZ. /evidence=ECO:0000250 1..115 46/101 (46%)
PB1_Par6 19..98 CDD:99724 40/80 (50%)
PDZ_signaling 157..248 CDD:238492 78/90 (87%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 254..295 9/40 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 311..330 3/18 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167841855
Domainoid 1 1.000 82 1.000 Domainoid score I8397
eggNOG 1 0.900 - - E1_KOG3606
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H36487
Inparanoid 1 1.050 299 1.000 Inparanoid score I2684
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D356104at33208
OrthoFinder 1 1.000 - - FOG0003376
OrthoInspector 1 1.000 - - otm42510
orthoMCL 1 0.900 - - OOG6_106218
Panther 1 1.100 - - LDO PTHR14102
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5019
SonicParanoid 1 1.000 - - X1143
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.790

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