DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment par-6 and PARD6B

DIOPT Version :9

Sequence 1:	NP_573238.1	Gene:	par-6 / 32752	FlyBaseID:	FBgn0026192	Length:	351	Species:	Drosophila melanogaster
Sequence 2:	NP_115910.1	Gene:	PARD6B / 84612	HGNCID:	16245	Length:	372	Species:	Homo sapiens

Alignment Length:	291	Identity:	162/291 - (55%)
Similarity:	212/291 - (72%)	Gaps:	24/291 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 IEVKSKFDAEFRRWSFKRNEAEQSFDKFASLIEQLHKLTNIQFLILYIDPRDNDLLPINNDDNFG 84
            :||||||.|||||:|.:|::..: |::|..|::.:||:.|:..|:.|.|.. .||||||||||:.
Human    17 MEVKSKFGAEFRRFSLERSKPGK-FEEFYGLLQHVHKIPNVDVLVGYADIH-GDLLPINNDDNYH 79

  Fly    85 RALKTARPLLRVIVQRKDDLNEYSGFGT---MKPRNLIGSILMGHTPVKTKAPSISIPHDFRQVS 146
            :|:.||.||||:.:|:|::. :||.|||   :|.:|::.::|......|.....||:|.|||.||
Human    80 KAVSTANPLLRIFIQKKEEA-DYSAFGTDTLIKKKNVLTNVLRPDNHRKKPHIVISMPQDFRPVS 143

  Fly   147 AIIDVDIVPETHRRVRLLKHGSDKPLGFYIRDGTSVRVTASGLEKQPGIFISRLVPGGLAESTGL 211
            :||||||:|||||||||.|:|::||||||||||:|||||..||||.||||||||||||||:||||
Human   144 SIIDVDILPETHRRVRLYKYGTEKPLGFYIRDGSSVRVTPHGLEKVPGIFISRLVPGGLAQSTGL 208

  Fly   212 LAVNDEVIEVNGIEVAGKTLDQVTDMMVANSSNLIITVKPANQRTLTSTHRGSFSRNSQLS-SGS 275
            |||||||:|||||||:||:||||||||:|||.||||||:||||       |.:..|||:.| |..
Human   209 LAVNDEVLEVNGIEVSGKSLDQVTDMMIANSRNLIITVRPANQ-------RNNVVRNSRTSGSSG 266

  Fly   276 HHTNNT----------NTSDEIEHDDQDDIV 296
            ..|:|:          :...|.|..::|||:
Human   267 QSTDNSLLGYPQQIEPSFEPEDEDSEEDDII 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-6	NP_573238.1	PB1_Par6	20..101	CDD:99724	40/80 (50%)
par-6	NP_573238.1	PDZ_signaling	159..250	CDD:238492	76/90 (84%)
PARD6B	NP_115910.1	PB1_Par6	17..96	CDD:99724	40/80 (50%)
		Interaction with PARD3 and CDC42. /evidence=ECO:0000250	126..253		100/133 (75%)
		PDZ_signaling	156..247	CDD:238492	76/90 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..292		9/38 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151749
Domainoid	1	1.000	82	1.000	Domainoid score	I8411
eggNOG	1	0.900	-	-		E1_KOG3606
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2767
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D356104at33208
OrthoFinder	1	1.000	-	-		FOG0003376
OrthoInspector	1	1.000	-	-		otm40434
orthoMCL	1	0.900	-	-		OOG6_106218
Panther	1	1.100	-	-	O	PTHR14102
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5019
SonicParanoid	1	1.000	-	-		X1143
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790