Protein Alignment par-6 and PARD6G

DIOPT Version :10

• Sequence 1: NP_573238.1
• Gene: par-6 / 32752
• FlyBaseID: FBgn0026192
• Length: 351
• Species: Drosophila melanogaster
• Sequence 2: NP_115899.1
• Gene: PARD6G / 84552
• HGNCID: 16076
• Length: 376
• Species: Homo sapiens
• Alignment Length: 313
• Identity: 163/313 - (52%)
• Similarity: 204/313 - (65%)
• Gaps: 30/313 - (9%)

  Fly    16 DTNLIEVKSKFDAEFRRWSFKRNEAEQSFDKFASLIEQLHKLTNIQFLILYIDPRDNDLLPINND 80
            |.:.:||||||.|||||:|..|::..: |:.|..|:...|.::|....|.|.|.. .||||||||
Human    15 DCSAVEVKSKFGAEFRRFSLDRHKPGK-FEDFYKLVVHTHHISNSDVTIGYADVH-GDLLPINND 77

  Fly    81 DNFGRALKTARPLLRVIVQRKDDLNEYS-GFGTM-KPRNLIGSILMGHTPVKTKAPSISIPHDFR 143
            |||.:|:.:|.|||||.:|::::....| |.|:: :.|..:|: |....|.:.....|.:|.|||
Human    78 DNFCKAVSSANPLLRVFIQKREEAERGSLGAGSLCRRRRALGA-LRDEGPRRRAHLDIGLPRDFR 141

  Fly   144 QVSAIIDVDIVPETHRRVRLLKHGSDKPLGFYIRDGTSVRVTASGLEKQPGIFISRLVPGGLAES 208
            .||:|||||:||||||||||.:||.:||||||||||.|||||..||||.|||||||:||||||||
Human   142 PVSSIIDVDLVPETHRRVRLHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGIFISRMVPGGLAES 206

  Fly   209 TGLLAVNDEVIEVNGIEVAGKTLDQVTDMMVANSSNLIITVKPANQRTLTSTHRGSFSRNSQLSS 273
            ||||||||||:|||||||||||||||||||:|||.|||:||||||||  .:..||.      .:.
Human   207 TGLLAVNDEVLEVNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQR--NNVVRGG------RAL 263

  Fly   274 GSHHTNNTNTS----------------DEIEHDDQDDIVDLTGVTLDESPTST 310
            ||....:..|:                ||.|.|:.:|:| :.|......|..|
Human   264 GSSGPPSDGTAGFVGPPAPRVLQNFHPDEAESDEDNDVV-IEGTLEPARPPQT 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
par-6	NP_573238.1	PB1_Par6	20..101	CDD:99724	40/80 (50%)
		PDZ_Par6-like	159..251	CDD:467202	78/91 (86%)
PARD6G	NP_115899.1	PB1_Par6	19..98	CDD:99724	40/80 (50%)
		Interaction with PARD3 and CDC42. /evidence=ECO:0000250	127..254		101/128 (79%)
		PDZ_Par6-like	157..249	CDD:467202	78/91 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..376