DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment par-6 and KIAA1614

DIOPT Version :9

Sequence 1:	NP_573238.1	Gene:	par-6 / 32752	FlyBaseID:	FBgn0026192	Length:	351	Species:	Drosophila melanogaster
Sequence 2:	NP_066001.1	Gene:	KIAA1614 / 57710	HGNCID:	29327	Length:	1190	Species:	Homo sapiens

Alignment Length:	364	Identity:	66/364 - (18%)
Similarity:	101/364 - (27%)	Gaps:	159/364 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 RALKTARPLLRVIVQRKD--------DLNEY---------SGFGTMKPRNLIGSI-LMGH----- 126
            |..:..|.:|..::|..|        ||.:|         :|.||.  ..|:||: ..||
Human   467 RLQQRQRQVLSTVLQAADQGPLRSKPDLADYINGAPRLRDAGQGTF--HRLVGSLDRRGHPAPPA 529

  Fly   127 -----------------TPVKTKAPSISIPHDFRQVSAIIDVDIVPETHRRVRLLKHGSDKPLGF 174
                             .|.:.|||  .:|...:::.|
Human   530 PGSERRCQACGSCIDDPRPAQGKAP--PVPRTLQELQA--------------------------- 565

  Fly   175 YIRDGTSVRVTASGLEKQPGIFISRLVPGGLAESTGLLAVN-----DEVIEVN-GIEVAGKTLDQ 233
                       |.|:|:         |.|||:....||...     :.:.|.: |..|....:|.
Human   566 -----------ACGMER---------VLGGLSSPLRLLPAEPRLHMEWIRETHIGDTVCPAEVDS 610

  Fly   234 VTDMMVANSSNLIITVKPANQ--------RTLTST------------HRGSFSRNSQLSSGSHHT 278
            ..| ...||.|.....:.|..        ||..|:            ||.|....::|..|....
Human   611 ALD-STDNSDNCRTDSEEAGTSQAGWACGRTQGSSPRLRLRGSRPRGHRWSKKAEAELPWGLQAQ 674

  Fly   279 NNTNTSDEIE--------------------HDDQDDIVDLTGVTLDESPTSTSAGNHNHQP---- 319
            .:...:|::|                    .|.:...::|..|:|... .....|..:|||
Human   675 QHLPRADDVEVENEVKEGRGHTPEGTLFLREDAKPPDLELKRVSLGPQ-WQPGPGLGSHQPHPLD 738

  Fly   320 ----------------PLSSSPSSHHQQAASNASTIMAS 342
                            |.||.|....|...|:.|..:.|
Human   739 SRTPCRTAYATTAPMTPESSGPGGQAQVTESHESLEIVS 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-6	NP_573238.1	PB1_Par6	20..101	CDD:99724	4/15 (27%)
par-6	NP_573238.1	PDZ_signaling	159..250	CDD:238492	17/96 (18%)
KIAA1614	NP_066001.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..77
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..223
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..366
		DUF4685	354..478	CDD:292365	3/10 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..457
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	613..663		11/50 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..823		16/94 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	831..850
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	877..930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..999
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1063
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1087..1106
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3606
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14102
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.000