DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment par-6 and PARD6A

DIOPT Version :9

Sequence 1:	NP_573238.1	Gene:	par-6 / 32752	FlyBaseID:	FBgn0026192	Length:	351	Species:	Drosophila melanogaster
Sequence 2:	XP_005256034.1	Gene:	PARD6A / 50855	HGNCID:	15943	Length:	357	Species:	Homo sapiens

Alignment Length:	350	Identity:	169/350 - (48%)
Similarity:	216/350 - (61%)	Gaps:	43/350 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AASDTNLIEVKSKFDAEFRRWSFKRNEAEQSFDKFASLIEQLHKLTNIQFLILYIDPRDNDLLPI 77
            |.|..:::||||||||||||::..| .:...|.:|:.|:..:|::..:..|:.|.|.. .||||:
Human     9 ARSPDSIVEVKSKFDAEFRRFALPR-ASVSGFQEFSRLLRAVHQIPGLDVLLGYTDAH-GDLLPL 71

  Fly    78 NNDDNFGRALKTARPLLRVIVQRKDDLNEYSG-------------FGTMK-PRNLIGSILMGHTP 128
            .|||:..|||.:..|.||::||::.: ..|||             |.:.. .|...|.:|....|
Human    72 TNDDSLHRALASGPPPLRLLVQKRGE-EGYSGQPLWAEADSSGLAFASNSLQRRKKGLLLRPVAP 135

  Fly   129 VKTKAP-SISIPHDFRQVSAIIDVDIVPETHRRVRLLKHGSDKPLGFYIRDGTSVRVTASGLEKQ 192
            ::|:.| .||:|.||||||::||||::|||||||||.|||||:|||||||||.||||...|||:.
Human   136 LRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERV 200

  Fly   193 PGIFISRLVPGGLAESTGLLAVNDEVIEVNGIEVAGKTLDQVTDMMVANSSNLIITVKPANQRTL 257
            |||||||||.||||||||||||:||::|||||||||||||||||||||||.|||:||||||||
Human   201 PGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQR-- 263

  Fly   258 TSTHRGSFSR-NSQLSSGSHHTNNTNTSDEIEHDDQDDIVDLTGVTLDESPTSTSAGNH------ 315
            .:..||:..| ....|:|         ....|.|..||..||  |..:..|.|::..:.
Human   264 NNVVRGASGRLTGPPSAG---------PGPAEPDSDDDSSDL--VIENRQPPSSNGLSQGPPCWD 317

  Fly   316 -----NHQPPLSSSPSSHHQQAASN 335
                 .|....||.||...|:.||:
Human   318 LHPGCRHPGTRSSLPSLDDQEQASS 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-6	NP_573238.1	PB1_Par6	20..101	CDD:99724	35/80 (44%)
par-6	NP_573238.1	PDZ_signaling	159..250	CDD:238492	76/90 (84%)
PARD6A	XP_005256034.1	PB1_Par6	16..95	CDD:99724	35/80 (44%)
PARD6A	XP_005256034.1	PDZ_signaling	167..258	CDD:238492	76/90 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151751
Domainoid	1	1.000	143	1.000	Domainoid score	I4675
eggNOG	1	0.900	-	-		E1_KOG3606
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2767
Isobase	1	0.950	-	0	Normalized mean entropy	S3196
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D356104at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40434
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14102
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5019
SonicParanoid	1	1.000	-	-		X1143
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840