DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment par-6 and Pard6a

DIOPT Version :9

Sequence 1:	NP_573238.1	Gene:	par-6 / 32752	FlyBaseID:	FBgn0026192	Length:	351	Species:	Drosophila melanogaster
Sequence 2:	XP_006255552.1	Gene:	Pard6a / 307799	RGDID:	1303273	Length:	346	Species:	Rattus norvegicus

Alignment Length:	318	Identity:	157/318 - (49%)
Similarity:	205/318 - (64%)	Gaps:	31/318 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 AASDTNLIEVKSKFDAEFRRWSFKRNEAEQSFDKFASLIEQLHKLTNIQFLILYIDPRDNDLLPI 77
            |.|..:::||||||||||||::..|... :.|.:|:.|:..:|::..:..|:.|.|.. .||||:
  Rat     9 ARSPDSIVEVKSKFDAEFRRFALPRTSV-RGFQEFSRLLCVVHQIPGLDVLLGYTDAH-GDLLPL 71

  Fly    78 NNDDNFGRALKTARPLLRVIVQRKDDLNEYSGF---GTMKPRNLIGSILMGHTPVKTKAP-SISI 138
            .|||:..|||.:..|.||::||::.: .:.||.   .....|...|.:|....|::|:.| .||:
  Rat    72 TNDDSLHRALASGPPPLRLLVQKRAE-GDSSGLAFASNSLQRRKKGLLLRPVAPLRTRPPLLISL 135

  Fly   139 PHDFRQVSAIIDVDIVPETHRRVRLLKHGSDKPLGFYIRDGTSVRVTASGLEKQPGIFISRLVPG 203
            |.||||||::||||::|||||||||.|||||:|||||||||.||||...|||:.|||||||||.|
  Rat   136 PQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRG 200

  Fly   204 GLAESTGLLAVNDEVIEVNGIEVAGKTLDQVTDMMVANSSNLIITVKPANQRTLTSTHRGSFSRN 268
            |||||||||||:||::|||||||||||||||||||||||.|||:||||||||  .:..||:..|
  Rat   201 GLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQR--NNVVRGASGR- 262

  Fly   269 SQLSSGSHHTNNTNTSDEIEHDDQDDIVDLTGVTLDESPTSTSAGNHNHQPPLSSSPS 326
               .:|........|..:.:.|:.|.:::                  |..||.|:..|
  Rat   263 ---LTGPSSVGPGPTDPDSDDDNSDPVIE------------------NRHPPCSNGLS 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
par-6	NP_573238.1	PB1_Par6	20..101	CDD:99724	35/80 (44%)
par-6	NP_573238.1	PDZ_signaling	159..250	CDD:238492	76/90 (84%)
Pard6a	XP_006255552.1	PB1_Par6	16..95	CDD:99724	35/80 (44%)
Pard6a	XP_006255552.1	PDZ_signaling	156..247	CDD:238492	76/90 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345238
Domainoid	1	1.000	143	1.000	Domainoid score	I4554
eggNOG	1	0.900	-	-		E1_KOG3606
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D356104at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44574
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14102
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1143
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.810