DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chas and Zc3h13

DIOPT Version :9

Sequence 1:	NP_001285381.1	Gene:	chas / 32748	FlyBaseID:	FBgn0263258	Length:	1558	Species:	Drosophila melanogaster
Sequence 2:	NP_001163942.1	Gene:	Zc3h13 / 305955	RGDID:	1307729	Length:	1728	Species:	Rattus norvegicus

Alignment Length:	1583	Identity:	315/1583 - (19%)
Similarity:	505/1583 - (31%)	Gaps:	487/1583 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VVILLLSPCTCSRSSSS--SHAHDHAHDPGHAPSKHHHQYHQYHQHQQHHQNSQHHQQ----PEQ 60
            ||...|||....:||.|  ..:...|...|....|...........|::.:::|..::    |..
  Rat   201 VVRSKLSPSPLRKSSKSPKRKSSPKASSAGKKERKAAVVASPLLDQQRNSKSNQSKKKGPRTPSP 265

  Fly    61 PPSVARSGDSRSSNESSSASTGDTAIPAGYLQLHHQKQN---------------QNQNQKDPQNR 110
            ||.:..                |..:...|.:.:..|..               :.|.:|..:.|
  Rat   266 PPPILE----------------DIILGKKYKEKYKVKDKIEEKPRDGKDRGRDFERQREKRDKPR 314

  Fly   111 QHSDNYPHQP----SHSCSTATNTAPLSVFGHGCWMPQQPANAVPKPPRSH----GLQWSSSAYP 167
            ..|....|.|    .||.|:.:.:   |:..|.   |.......|.|....    .|:.|:|.||
  Rat   315 SSSPGQHHSPLSSRHHSSSSQSGS---SIQRHS---PSPRRKRTPSPSYQRTLTPSLRRSASPYP 373

  Fly   168 ATHATSHQPVIFRVQSSLPNGSFTNATTTTTTTTDYVRHVTRVNFYDIDTSQVEFEPKDDEESNE 232
             ||..|...   |.||...:.|         ...:..||         |..:.........|..|
  Rat   374 -THCLSSPQ---RKQSPPRHRS---------PMREKGRH---------DHERTSQSHDRRHERRE 416

  Fly   233 VTASNCDTEAITKEEEWITKRKTE---------LTTTRQIETRVKRQVKLQDGKVIEDSGPI--V 286
            ......|.|..|:||     |::|         ..:..:.:||.:|:  |:|.:.:.||..|  .
  Rat   417 EARGKRDREKDTREE-----RESEHDHRDDREPRDSRDRRDTRDRRE--LRDSRDMRDSREIRDY 474

  Fly   287 STNTTEDTDKQETETTEKRDLDLPDDLDGNAQLIDVAALQAGAINETQLAQ-IQEVFGPADGAGK 350
            |.:|.|..|.:::.:..    |:.|..|..|:  |..|.....:.:.:.|: :::|....|...
  Rat   475 SRDTKESRDPRDSRSAR----DVHDYRDREAR--DAHARDVRDVRDARDARDVRDVRDVRDARD- 532

  Fly   351 LVKRMVPRPVDGLVRQTDDKRVISHEEIKDYHETEDVQHHGDFTDQTYVNAVRDG-----VENLE 410
                         ||...|.|.:  .:.:|..:..||:...|..|.......|||     |...|
  Rat   533 -------------VRDVRDARDV--RDARDVRDVRDVRDVRDTRDARDARDARDGHRKEDVYQEE 582

  Fly   411 AVLCSPESQRQLVPLGPKVVANRSKSRKTIDSEDTQKRCLAQEDGTLVTESRRTTEHELIVDDEL 475
            |                     ||..|..:..|.::..        |..:||..:..| |.:|.:
  Rat   583 A---------------------RSYGRNHLREESSRVE--------LRNDSRNESRSE-IRNDRM 617

  Fly   476 -------PDPPANGASDDLGLQL---QVGEQVTTTAANQRFFRQRDE-QHVDVLANGRLQSTEMR 529
                   |:.|..|.....|.|:   ..|.....:...:..:.:||. ...|.....|..|.|.|
  Rat   618 GRSRGRGPELPEKGGRSTRGSQMDSHSSGSNYHDSWETRSSYPERDRYPERDTRDQARDSSFERR 682

  Fly   530 YAAETTQMDKDGPTDLERPGDWDSLSDRMRKLRRSQQQQQKEVALLADRKDALTKRPLDFDREEE 594
            :.....:.:::..   :||........|..:|.|.::::::.:..:.:|:|   :|..|.|||.|
  Rat   683 HGERDRRDNRERD---QRPSSPIRHQGRSEELEREERREERRIDRVDERRD---ERVRDRDRERE 741

  Fly   595 ---------TRKGETMKWLESHFGSESTASND-SRDDEADAEVEPTKKSYFNVTIKSQSHAQSHL 649
                     .|:.|..|..|.....|.....: .|:.|.:.|.|..:..      :.:.|.:...
  Rat   742 RERERERDREREREREKERERELERERAREREREREKERERERERERDQ------RDRDHDRERE 800

  Fly   650 ATQQHSHPQHISHGHHPQTLPRSAERER-ERERERERERERERERERDRDRHPLAMTASASQERK 713
            ..::..               |..|||| ||||||||||||||||||:|:|         .:||:
  Rat   801 RERERE---------------REKEREREERERERERERERERERERERER---------ERERE 841

  Fly   714 APANSAGGRSKYFQGISNWSERKDPGPPVNHFSSQAFRDDLQE----------TIRRNGLKKKVS 768
            .....|..|.|..:....| |.||.|           |||.:|          .|.|:|.:::.|
  Rat   842 RERERAREREKERERQREW-EDKDKG-----------RDDRREKREDVHVREDRIPRDGHEERKS 894

  Fly   769 -------GPGSSQGSALAQETVVQPKDSYVSRED-----------ILQQKRQSLSSQFLARSMRG 815
                   |..|.:.|...:.......|:|.|.:|           :..|:.:|||...|....:|
  Rat   895 KKRYRNEGSPSPRQSPKRRREHSPDSDTYHSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQG 959

  Fly   816 S----------------------RDAL-------DDLEAIPGPGPGPS---MISPRAEEP----- 843
            .                      ::.|       :..|::.|.....|   ::|.|..|.
  Rat   960 RWKEEERKSERKESSRRYEEQELKEKLSCGDRQREQTESVDGGSRARSAQDLLSHRQAEDRDRDG 1024

  Fly   844 -----SHKRVAYG---------------HRGNNGTHINGHALN---------------------- 866
                 ..|:.|..               .|||..||.:....:
  Rat  1025 SDRAHDEKKKAKAPKKPVKKKREEDVGIERGNPETHEDSQVFSPKKGQKKKNIEKKRKRSKGDSD 1089

  Fly   867 ----GVAPTLVNGRGKSYEPPAPPPAAVPP--LEFGGGGSQLGQNP------------RPTVPQR 913
                ..||.....||     |..||.|:..  :|.......:.::|            ...||.|
  Rat  1090 VSDEEAAPQSKKKRG-----PRTPPLAIKEELIEISTDKEGILEDPLKKEDTAFSDWSDEDVPDR 1149

  Fly   914 RRAIEKKLGEHSHTHSHSHSHSSHTSHSAHLPVKSQAPMPSQLNQLEPPPDYSPPPRS------- 971
            ...:|                :.||:.:|     :....||.::.|.|||   ||..:
  Rat  1150 TDGLE----------------AEHTAAAA-----TPGSTPSPMSSLLPPP---PPVAAAGTAATA 1190

  Fly   972 ----------------------------------RSRSSSPQVDYLMTREMPASTMTLSRKQQQR 1002
                                              |:|....:|.::...:.|...:.   .|::.
  Rat  1191 LAASAISATTSTTISSSGATSNINASEDSHRKCHRARGEKVEVSHVTLEDTPHRKLV---DQKRS 1252

  Fly  1003 TRFAPTSSYPPATGGTGNLRPPGATSVSTSNLSAMSGGVSTSKSSRMGQVIGNSLRKLVSKIRSA 1067
            :......|:...|  :|.||.|       ||.||...|  ..:..|...:...|..:..:|....
  Rat  1253 SSLGSNRSHRSHT--SGRLRSP-------SNDSAHRSG--DDQGGRKRVLHSGSRDREKTKSLEL 1306

  Fly  1068 SAERKFRMK--SAASKSREQSPSPGQDPRGVGPPVTTYQQYNVIDGHIGSHDSED-----SNSDN 1125
            :.|||.|:.  .....||..| |..||.|......::.:....:....||.||.|     ...::
  Rat  1307 TGERKSRIDQLKRGEPSRSTS-SDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEH 1370

  Fly  1126 QRRRERERERERERERERERDPLKQESQSRQNFKRAESADPQLQHLEQAISPRQRYYLGEDPYSS 1190
            .|.|||||...|:||.:||.|.....::.|...:..|....:.:.|:     |:|..|..||..
  Rat  1371 DRERERERRDPRQREWDREADKEWPRTRDRDRLRERERDRDKRRDLD-----RERERLVADPME- 1429

  Fly  1191 TLYGKENHYERRPRQRNMERTDERMERLERLEREDDYYESRAPPPVTAAHTLGRYQKHGQRFSGS 1255
                         |.|..:||.| ..:||.::|.:...||                :|.:...||
  Rat  1430 -------------RDRERDRTFE-TSQLESVKRSEVKLES----------------EHDRDLEGS 1464

  Fly  1256 TP-----NLHQQQQDYRSAQTLPRKLHEQRTQRFGNAMEKQPAPGRGSYLSASGQQQQS------ 1309
            :.     :..:..:|..|||........:||:......::.......|..|.:|:..:.
  Rat  1465 SRDSVALDKERMDRDLGSAQGFEDVSKAERTESLEAGDDESKLDDAHSLGSGAGEGYEPISDDEL 1529

  Fly  1310 ----RGIPHNQNQQNQQNPNPSP 1328
                .|....:..|.::...|.|
  Rat  1530 DEILAGDAEKREDQQEEEKMPDP 1552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
chas	NP_001285381.1	None
Zc3h13	NP_001163942.1	zf-CCCH	42..63	CDD:279036
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000