DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12990 and oac-32

DIOPT Version :9

Sequence 1:	NP_573233.1	Gene:	CG12990 / 32747	FlyBaseID:	FBgn0030859	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_001300114.1	Gene:	oac-32 / 186125	WormBaseID:	WBGene00018708	Length:	707	Species:	Caenorhabditis elegans

Alignment Length:	782	Identity:	148/782 - (18%)
Similarity:	280/782 - (35%)	Gaps:	254/782 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLVLLLLQIIAALGDVDNCEPKSLA--KDLIEMVPQRENTTLSKCEEQLLELRRAWQDHQSWAL 63
            :.|::|||.||          |.:.|  ||:|:..|      |.....|.|      .|..:| :
Worm     6 IFLIILLLNII----------PTTSATWKDVIKPKP------LDNLSAQCL------NDTNTW-I 47

  Fly    64 KAIDASGEGYANFMMGQRAWLGNRFTCRAVNEPMLQD-------------------MTIKN---- 105
            .:::..|..||..::.::        |.|....:|:|                   :.:|.
Worm    48 NSLEIFGTLYAECIIMKK--------CNAKELKVLRDNLYAVQQLDAFGQFPGAGLLELKTLYDG 104

  Fly   106 -----QRLLREMSPIQFHYLV----AYIESNSPWQLEVTIKANPLLHIGLCLPASCDVPEVEQLI 161
                 ||:..:...:.:.||:    ..:.|.:|...:......| |.|.:|||.||:..::..:.
Worm   105 SYQECQRVSGKKYDVNYCYLLLTPGKNVSSCAPSNSKSLYSQLP-LRIAVCLPDSCNHQDMIDIF 168

  Fly   162 RKSMAKEESFHCWDMDAKLAYAKKPELK--TNFFDSGAVQIFFVVLGVTLLLTLAATSGLGKYSR 224
            .:       ...:...|..||..|.|:|  |.|:   ...||.:|     ::.:||.:.:..|.|
Worm   169 NE-------LSPYPFTACSAYCTKNEVKKDTPFW---GFSIFLIV-----MVVIAAIASIVDYVR 218

  Fly   225 -----------------ILACFDFADNWRLAWKPVNPSQEN----RPVNGLRVLTAFSLIGVHVI 268
                             ||..|..   |..|...::..::.    :.::.:|:|:...::..|..
Worm   219 ETVYGLSSQKENNTFFKILLTFSL---WTNAELLLSVKEQKSGFIKSLDCIRLLSMCWVVTGHSF 280

  Fly   269 WYKYF--SVDPSVEMLGKLSSMTMRHTY-WPTM-------VEIFFVVSGYLTVLNFIRDEQLQKD 323
            .|...  :::|.::.          .|| |..:       |:.|||:||.:....|.:.:..:|.
Worm   281 LYLILADTLEPVLDF----------PTYFWNHLLLNAFVSVDTFFVLSGIVVAYLFFKTKLTKKT 335

  Fly   324 IASDGILGNMRRYLREFIHRYCRLAPLQFVIVLMGVVVIEY-QRQVSVMQITD--PQDELCRLNA 385
            |.|.      ..::..::|||.||.|...:.:....|...| |...|..::..  ||...|:...
Worm   336 ITSP------MTWILFYVHRYLRLTPPVMLFIGFFTVYTPYIQGAFSASELNQMAPQAAACKTLW 394

  Fly   386 VRNVFFIQNLFPIQF--------MCGSWTWSLGCDMQLHMTAMLLLF-----MHTKHPNMVKWIV 437
            .:|:.:|.|     |        .|...||.|..|.||::.|.::|.     .......:|...|
Worm   395 WQNLLYINN-----FDDGNSQNSTCYGITWYLAVDTQLYLVAPIVLVALYFSFAAGTAIIVAGCV 454

  Fly   438 RLLVVISALFSIVFMEVNEVGANFEEMYHTNEWSYMSPLIRMLAYIIG-------GSYAFFQVKG 495
            ..::....||.:..:..:.:| |.::....| .:|..|.||...|::|       .:|...:::
Worm   455 GSIITTYILFGVYNVPADIIG-NGDQTKFFN-IAYSKPWIRCPPYLVGLLTGYLLATYGSRKIR- 516

  Fly   496 TGTPFDLVMPNWWIRLGAIACIGWLARQVTMDQLPAISIILSFMVVLRILVST----AASH---- 552
                     .||     |:|..||               |.:|::....|.:|    ..:|
Worm   517 ---------LNW-----ALAIAGW---------------ITAFVIAGFCLFATYDYDKGAHWSTF 552

  Fly   553 --------------LIICGTKPDNSDSYAPTRWLLAL-----------LQSEQV-QRISKFTYAI 591
                          :.:|              |::..           ..|..: |...:.:|..
Worm   553 TRATFYNFHRLGWGVFVC--------------WVVGANHMGWGGPIDKFMSHPIWQPFGRLSYCA 603

  Fly   592 YLLNPIVIMY-------VYHSFSNEVYPDNTMMIMLAISCSVVCYLWAIVMTVLFEIPFNRLTSV 649
            |:::.:|:.|       :::|.:.:|:      ..:||..:::.|:.|...:.|||:|..:|..:
Worm   604 YIVHWMVLYYYLNVGGVLHYSSAWQVF------TYIAIPATLLSYVLAFFWSCLFEVPILKLEKM 662

  Fly   650 MI 651
            :|
Worm   663 LI 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12990	NP_573233.1	NRF	61..162	CDD:214781	23/132 (17%)
		Acyl_transf_3	251..637	CDD:280013	83/459 (18%)
		OafA	295..660	CDD:224748	82/428 (19%)
oac-32	NP_001300114.1	NRF	77..185	CDD:214781	18/115 (16%)
oac-32	NP_001300114.1	OafA	254..659	CDD:224748	87/477 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161227
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850