DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12990 and oac-20

DIOPT Version :9

Sequence 1:	NP_573233.1	Gene:	CG12990 / 32747	FlyBaseID:	FBgn0030859	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_507007.3	Gene:	oac-20 / 185375	WormBaseID:	WBGene00009488	Length:	719	Species:	Caenorhabditis elegans

Alignment Length:	766	Identity:	138/766 - (18%)
Similarity:	262/766 - (34%)	Gaps:	261/766 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 AKDLIEMVPQRENTT----------------------LSKCEEQLLELRRAWQDHQSWALKAIDA 68
            :|:|..:.||..|.|                      .||.||.||.       ...:||:.:|:
Worm    32 SKNLTGVNPQCNNDTETWLHSLDILTEVSLECILSKKCSKKEELLLR-------DNFYALEQLDS 89

  Fly    69 SGEGYANFMMGQRAWLGNRFTCRAVNE-PMLQDMTIKNQRLLREMSPIQFHYLVAYI-------- 124
            .|                :|....:.| |::.|.:.:....:...|..::.....|:
Worm    90 FG----------------KFPSIGLFEVPLIFDGSYQECERISGKSETKYETNYCYVLLIPGKNS 138

  Fly   125 ----ESNSPWQLEVTIKANPLLHIGLCLPASCDVPEVEQLIRK--------------SMAKEESF 171
                |:.|......|:    .....:|:|.||:..|:..:|.:              |...|::.
Worm   139 SHCHETKSGDLSPTTL----FFRSAVCMPNSCNQREISDIINEISDIPFTACGSQCSSYPVEKNS 199

  Fly   172 HCWDMDAKLAYAKKPELKTNFFDSGAVQIFFVVLGVTLLLTLAATSGLGKYSRILACFDFADNWR 236
            ..|                      ...:|.:|:   :.:.:.|||           .|:
Worm   200 AFW----------------------GFSVFMIVM---ISIAILATS-----------VDY----- 223

  Fly   237 LAWKPVNPSQENRPVNG----LRVLTAFSL-------IGV---HVIWYKYFSVDPSVEMLGKLSS 287
             ....:...:|.|..|.    |::|.:|||       :.|   .|.:.|.......:.||..:|.
Worm   224 -ILDAIATDEEQREKNKRHLLLKILISFSLWTNAELILSVKEQKVGFIKCLDCIRFLSMLWVVSG 287

  Fly   288 MTMRHTYWPTM----------------------VEIFFVVSG----YLTVLNFIRDEQLQKDIAS 326
            .|:.:..:|.:                      |:.||::||    ||...|.::..|::..:.
Worm   288 HTVSNIMFPDVLLPVTTFTKHFWNHLLLNAFVSVDTFFLLSGIVVSYLFFKNRMKSSQIKSPLT- 351

  Fly   327 DGILGNMRRYLREFIHRYCRLAPLQFVIVLMGVVVIEYQR--------QVSVMQITDPQDELCRL 383
                     ::..::|||.||.|...:.:...:|..||.:        ..::..:     |.|:.
Worm   352 ---------WILFYVHRYLRLTPPYMIFLGFYIVYSEYVQGPTAAAGLNAAIYSV-----ESCKK 402

  Fly   384 NAVRNVFFIQNLFPIQFMCGSWTWSLGCDMQLHMTAMLLLFMHTKHPNMVKWI------------ 436
            ...||:.:|.|.......|.:.||.|..|.||::.|.::|        :..|.
Worm   403 TWWRNLLYINNFGDSTHACYAITWYLAVDTQLYLIAPIVL--------IALWFSFVWGALAVAAG 459

  Fly   437 -VRLLVVISALFSIVFMEVNEVG----ANFEEMYHTNEWSYMSPLIRMLAYIIGGSYAFFQVKGT 496
             ...:|.:..|::...:..::.|    .:|.::.:...|...:|.  ::..::|...|.|..:..
Worm   460 CAGSIVTVYVLYAEYHLPADQFGKGSLLDFGKILYQKPWVRCTPY--LIGLLVGYGLAVFGKRRV 522

  Fly   497 GTPFDLVMPNWWIRLG-AIACI----GWLARQVTMDQLPAI---------SIILSFMVVLRILVS 547
            ...:.|.:..|.|..| |:||:    .:....|..|...|.         :|.:|:::|
Worm   523 RLHWALAVVGWLIAFGIAVACLFSTNDYDKGAVWSDFEKATYYNFSRFFWAIAVSWVIV------ 581

  Fly   548 TAASHLIICGTKPDNSDSYAPTRWLLALLQSEQVQRISKFTYAIYLLNPIVI----------MYV 602
              |:|:...|  |.|:....|. |          |...|.:|..|:::..:|          |:.
Worm   582 --ANHMGWGG--PINNFMSHPI-W----------QPFGKLSYCAYIVHFFLISWYTNISEAPMHY 631

  Fly   603 YHSFSNEVYPDNTMMIMLAISCSVVCYLWAIVMTVLFEIPFNRLTSVMINS 653
            |.:|...:|        .|:..:::.|::|...:.|||||..:|..::|.:
Worm   632 YSTFQVWIY--------YAVPVTIIAYIFAFFWSCLFEIPTLKLEKMLIEA 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12990	NP_573233.1	NRF	61..162	CDD:214781	18/113 (16%)
		Acyl_transf_3	251..637	CDD:280013	89/474 (19%)
		OafA	295..660	CDD:224748	83/434 (19%)
oac-20	NP_507007.3	NRF	80..192	CDD:214781	19/131 (15%)
oac-20	NP_507007.3	Acyl_transf_3	270..654	CDD:376607	80/437 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161224
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850