DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta-Spec and Clmn

DIOPT Version :9

Sequence 1:	NP_001259660.1	Gene:	beta-Spec / 32746	FlyBaseID:	FBgn0250788	Length:	2308	Species:	Drosophila melanogaster
Sequence 2:	NP_444385.2	Gene:	Clmn / 94040	MGIID:	2136957	Length:	1052	Species:	Mus musculus

Alignment Length:	1161	Identity:	275/1161 - (23%)
Similarity:	418/1161 - (36%)	Gaps:	358/1161 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RIKALAEERESVQKKTFTKWVNSHL--CRVNCRIADLYVDMRDGKHLIKLLEVLSGERLPKPTKG 102
            |::.|..|||:|||:|||:|:|.||  |.....:.||:||::|||.|:.|||||||..|....|.
Mouse    22 RVQNLQVERENVQKRTFTRWINLHLEKCDPPLEVTDLFVDIQDGKILMALLEVLSGRNLLHEYKS 86

  Fly   103 KM-RIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDIT------- 159
            .. ||..|.|:.|||:||.:..|.|.:|.:.:|.|||.||.|||||.|||.|||:::|
Mouse    87 SSHRIFRLNNIAKALKFLEDSNVKLVSIDAAEIADGNPSLVLGLIWNIILFFQIKELTGNLSRSS 151

  Fly   160 --------------------------IEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSW 198
                                      ...|..|:.:.|...||.|.|.||..| .|.|::|..||
Mouse   152 PSSSLSPGSGGTDSDSSYPPTPTTERSVAVAVKDQRKAIKTLLSWVQRKTRKY-GVAVQDFAGSW 215

  Fly   199 RDGLAFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSII 263
            |.||||.|:|....|.||..::..:.:...||..||.:|.|.|.:.:||:.||:.|:.|||:||:
Mouse   216 RSGLAFLAVIKAIDPSLVDMKQALEDSTRDNLEKAFSIAHDSLHIPRLLEPEDIMVDMPDEQSIV 280

  Fly   264 TYVVTYYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFEN 328
            |||..:...|.:|:.|                      |:.|  .|....||:|...:.|...|.
Mouse   281 TYVAQFLERFPELEPE----------------------DFVN--PDKEAPIESTFVRIKESPSEQ 321

  Fly   329 S----LAGVQGQLAQFSNYRTIEKPP-KFVEKGNLEVLL-FTLQSKMRANNQKPYTPKEGKMISD 387
            .    |....|:.|...|..|...|| |......||... |.|.|   |.:.|         :||
Mouse   322 GSRVLLLSENGERAYTVNQETSYPPPDKVFVCDQLESPTGFCLDS---APSHK---------LSD 374

  Fly   388 INKAWERLEKAEHERELALREELIRQ-------------EKLEQLAARFDRKASMRETWLSENQR 439
            .:..:              ..|:|.|             |...:.:....||...|...|...:.
Mouse   375 SSTEF--------------MHEIIDQVLQGSTGKTGSIAEPTPESSILSTRKDGRRSNSLPVKKT 425

  Fly   440 LVSQDNFGFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDELESERYH----DVKRILLRKD 500
            :    :|..||.. :|:..|.....:| |.:|...:|.    .||..:..|    :|.:...:.:
Mouse   426 V----HFEADLHK-DASCSKDPFYSSD-FRFEGSPKAT----KELSKQDGHVSLAEVSKEKKKSE 480

  Fly   501 NVMRLWTYLLELLRARRMR--------LEISLQLQQNFQEMLY---------------------- 535
            ...||      :|.|...:        |:...|..|..|:..:
Mouse   481 QEARL------VLEAASDKVPESTVDGLDAVPQDAQPSQDSSFCNGTVESPSSQGEKGPPPSSPG 539

  Fly   536 ---ILDNMEEIK-QLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPE 596
               :|.|..|:| |||..:...|     ||..:...|..:..|    |..|...::.:...:||.
Mouse   540 DHTLLANSTELKVQLLTVEPMDK-----EDYFECIPLKASKFN----RDLVDFASTSQAFGEDPS 595

  Fly   597 SYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLE--------ESRKLWQFYWDTADEENWIKE 653
            |::....|      ::..:.:||.......:..|.|        |.:||          |...|:
Mouse   596 SHEKTRGE------EEGSENHAEKPGKRKSKSPRAETEAAESRLEPKKL----------EPPPKD 644

  Fly   654 KEQIVSTDEVGHDLTTVNLMLSKHKALES---EITSHDPQLQNVAKVGSELITEGHFGADRIKDR 715
            .||    ::.||.|........|.|..|.   :.|.|..:.:..|:.|...:.|
Mouse   645 PEQ----EDQGHALPPETPADKKPKVYEKAKRKSTRHHSEEEGEAESGFSAVCE----------- 694

  Fly   716 LKEILNKWDHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRD-------- 772
             :||                            ..|....:..|:|||..|.|  |.|
Mouse   695 -EEI----------------------------PSAPPSTSVSLETLRSHSEE--GLDFKPSPPLS 728

  Fly   773 ---------------EANVQSLLKKHKDVADELKNYAEVIDALHKQAESLKLNEAEKANVDKRLE 822
                           |..:.::|:.:.:..::||  :|..|..|.:...|:.:..|:|:.|:. |
Mouse   729 KISVIPHDLFYYPHYEVPLAAVLEAYAEGGEDLK--SEDTDLEHPEDSYLQDSREEEADEDEE-E 790

  Fly   823 A------------IDNRYKELTELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPG 875
            |            :||.|..::|                 .:|..||..:   ..|..|...:|.
Mouse   791 AQSSQSSCSFSLPVDNSYPSVSE-----------------HVSHVDGSSE---GPTSALGPGSPP 835

  Fly   876 KDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHP------------NSDEILERQN 928
            .. ||     |:    .||...|.   .|.:|.:::..:.|.|            .|.:..|::.
Mouse   836 SH-ED-----HQ----PKETKENG---PVESQQSQEPPNPELPTKPLEEKLTEASTSSKKKEKRK 887

  Fly   929 HLNQEWSTL--------------REKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETD 979
            |::...|:|              ...:|.|:.. :::|...:.||. |.|             ..
Mouse   888 HMDHVESSLFIAPGTVRSSDDLEENSSEHKVPS-RNSHSDSSIYIR-RHT-------------NR 937

  Fly   980 SLEMDLTGVMTLQRRLSGMDRDLAAI----QAKLSSLEREANSIEDEHPEEAKIIR 1031
            |||:|....:.|:......||....:    ..||:.|..:...|..:...|.|..|
Mouse   938 SLELDHFSYVQLRNAADLDDRRNRVLNRYNSQKLTELILQFYGIRADMKREYKHAR 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta-Spec	NP_001259660.1	CH	51..149	CDD:278723	51/100 (51%)
		CH	170..269	CDD:278723	43/98 (44%)
		Spectrin	298..408	CDD:278843	25/115 (22%)
		SPEC	422..521	CDD:197544	21/110 (19%)
		SPEC	525..740	CDD:238103	45/251 (18%)
		SPEC	639..846	CDD:238103	43/244 (18%)
		SPEC	848..1058	CDD:238103	42/214 (20%)
		SPEC	955..1169	CDD:238103	18/81 (22%)
		SPEC	1170..1380	CDD:238103
		SPEC	1386..1484	CDD:197544
		SPEC	1488..1699	CDD:238103
		SPEC	1594..1806	CDD:238103
		SPEC	1807..2015	CDD:238103
		Spectrin	2018..>2078	CDD:278843
		PH	2167..2275	CDD:278594
		PH_beta_spectrin	2167..2274	CDD:269975
Clmn	NP_444385.2	Actin-binding	1..288		108/266 (41%)
		CH	33..134	CDD:278723	51/100 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	148..178		0/29 (0%)
		CH	191..286	CDD:278723	42/95 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..420		4/28 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..545		13/99 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..727		37/203 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..929		39/207 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920