DRSC/TRiP Functional Genomics Resources

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Protein Alignment beta-Spec and ACTN1

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_016877209.1 Gene:ACTN1 / 87 HGNCID:163 Length:1106 Species:Homo sapiens


Alignment Length:920 Identity:300/920 - (32%)
Similarity:439/920 - (47%) Gaps:188/920 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 QGPGNEYIDEYEYDGGNSSSRLFERSRIKALAE---ERESVQKKTFTKWVNSHLCRVNCRIADLY 75
            ||.|.....|..|...|.       .::|.|.|   :|.....:|||.|.||||.:...:|.::.
Human    28 QGIGKGKRKEEAYKSENP-------KKLKWLGEKTLKRPWSTSETFTAWCNSHLRKAGTQIENIE 85

  Fly    76 VDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGNAS 140
            .|.|||..|:.||||:|||||.||.:||||:|.:.||:|||.|:..:.|.|.:||:.:|||||..
Human    86 EDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK 150

  Fly   141 LNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFN 205
            :.||:||||||||.||||::||.      |||:.||||||.|||.|.|||::||..||:|||.|.
Human   151 MTLGMIWTIILRFAIQDISVEET------SAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC 209

  Fly   206 AIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVF-VEHPDEKSIITYVVTY 269
            |:||:|||:|:.:.||.|.:.:.|||.||||||..|.:.|:|||||:. ...||||:|:|||.::
Human   210 ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSF 274

  Fly   270 YHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQ 334
            ||.||..::......||.||:.:..||::::.|||...||||:||..||..|..|..||::..:|
Human   275 YHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQ 339

  Fly   335 GQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKAE 399
            .:|..|.:||.:.||||..||..||:...|||:|:|.:|:..:.|.||:|:||||.||..||:.|
Human   340 QKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVE 404

  Fly   400 HERELALREELIRQEKLEQLAARFDRKASMRETWL---------SENQRLVSQDNFGFDLAAVEA 455
            ...|..|..|:.|.|:|:.||.:|.:|||:.|.|.         .:...|..:|.....|:.::|
Human   405 KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDAMWPSLNPGKEAMLRQKDYETATLSEIKA 469

  Fly   456 AAKKHEAIETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRL 520
            ..|||||.|:|:.|:::||:.:.|:..||....|:|...:..|...:...|..|..|.:.||..|
Human   470 LLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREAL 534

  Fly   521 EISLQLQQNFQEMLYILDNMEEIKQLLMTDDYGKH-------LMGVEDLLQKHSLVEADINILGE 578
            |.:.:|             :|.|.||.:  :|.|.       :.|..:.||...:|.....|.| 
Human   535 ERTEKL-------------LETIDQLYL--EYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQG- 583

  Fly   579 RVKVVVQNSQKFLSDDPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWD 643
                        |:...|.:|...|:             |:..|||:                  
Human   584 ------------LTTAHEQFKATLPD-------------ADKERLAI------------------ 605

  Fly   644 TADEENWIKEKEQIVSTDEVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFG 708
             ....|   |..:||.|..|             :.|..:..|:..||                  
Human   606 -LGIHN---EVSKIVQTYHV-------------NMAGTNPYTTITPQ------------------ 635

  Fly   709 ADRIKDRLKEILNKWDHLLDLTKYRRQRL--ENAVEYF------QLFADADDVDNWMLDTLRIVS 765
                     ||..||||:..|...|.|.|  |:|.:..      |..|.|:.:..|:...:    
Human   636 ---------EINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKM---- 687

  Fly   766 SEDVGRDEANVQSLLKKHKDVADELK----------NYAEVIDALHKQAESLKLNEAEKANVDKR 820
             |::||..      ::.|..:.|:|.          ||...||.|          |.:...:.:.
Human   688 -EEIGRIS------IEMHGTLEDQLSHLRQYEKSIVNYKPKIDQL----------EGDHQLIQEA 735

  Fly   821 LEAIDNRYKELT-ELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIM 884
            | ..||::...| |..::..::||..::  :.::|.:         .::|.....|...|.:...
Human   736 L-IFDNKHTNYTMEHIRVGWEQLLTTIA--RTINEVE---------NQILTRDAKGISQEQMNEF 788

  Fly   885 KHRFEGFDKE 894
            :..|..||::
Human   789 RASFNHFDRD 798

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 49/97 (51%)
CH 170..269 CDD:278723 58/99 (59%)
Spectrin 298..408 CDD:278843 49/109 (45%)
SPEC 422..521 CDD:197544 31/107 (29%)
SPEC 525..740 CDD:238103 42/223 (19%)
SPEC 639..846 CDD:238103 45/225 (20%)
SPEC 848..1058 CDD:238103 7/47 (15%)
SPEC 955..1169 CDD:238103
SPEC 1170..1380 CDD:238103
SPEC 1386..1484 CDD:197544
SPEC 1488..1699 CDD:238103
SPEC 1594..1806 CDD:238103
SPEC 1807..2015 CDD:238103
Spectrin 2018..>2078 CDD:278843
PH 2167..2275 CDD:278594
PH_beta_spectrin 2167..2274 CDD:269975
ACTN1XP_016877209.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D543832at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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