DRSC/TRiP Functional Genomics Resources

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Protein Alignment beta-Spec and dmd

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:NP_001313616.1 Gene:dmd / 83773 ZFINID:ZDB-GENE-010426-1 Length:3609 Species:Danio rerio


Alignment Length:2793 Identity:600/2793 - (21%)
Similarity:1059/2793 - (37%) Gaps:737/2793 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 PGNEYIDEYEYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRV-NCRIADLYVDMR 79
            |.:::.:.:|.:.|..         ||..::|||.|||||||||:||...:. ...|.||:.|:.
Zfish     7 PQDQWEEGFEDEFGEI---------IKTRSDEREDVQKKTFTKWINSQFAKTRRPPIDDLFTDLC 62

  Fly    80 DGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLG 144
            ||:.|::|||||.|..:.| .:|..|:|.|.||::|||.|::..|.|.|||..||||||..|.||
Zfish    63 DGRRLLELLEVLVGHEIVK-ERGFTRVHSLNNVNRALQILQKNNVDLVNIGGADIVDGNHKLTLG 126

  Fly   145 LIWTIILRFQIQDITIEEV--DNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAI 207
            |||:|||.:|::|: :::|  |.::|.|.| .||.|.:.....|.:|||.||::||.||.||||:
Zfish   127 LIWSIILHWQVKDV-MKDVMADLQQTNSEK-ILLSWVRQSLKNYQDVNVVNFSSSWADGFAFNAL 189

  Fly   208 IHKHRPDLVQFEKL-SKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYH 271
            ||.|||:|..:..: .:.|||..|::||.|||..||:.:|||.|||...|||:||||.||.:.: 
Zfish   190 IHSHRPELFSWSVVEQQDNAIERLDHAFGVAEKSLGIDRLLDPEDVATVHPDKKSIIMYVTSLF- 253

  Fly   272 YFSKLKQETVQGKRIGKVV--GIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQ 334
                            ||:  |:::|              .::.:||..::...:| |:.|...|
Zfish   254 ----------------KVLPHGVSLE--------------AIQEVETLPRAAVTKE-EHVLYQTQ 287

  Fly   335 GQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMR-------------ANNQKPY--TPKEGK- 383
            .:.:|                   ::.:...||::|             |..|..|  ||::.: 
Zfish   288 QRYSQ-------------------QITVSVAQSRVRSPSPSYKPRFKSYAFTQAAYVKTPEQQRK 333

  Fly   384 -MISDINKAWERLEKAEHERELALREELIRQEKLEQLAARFDRKASMRETW-LSENQRLVSQDNF 446
             :|:......:.|..:.......|.|....|..||::.           || ||....|.:|...
Zfish   334 FLIAQSPDKADELRPSPSPLPQGLNELESYQSALEEVL-----------TWLLSAEDGLQAQPPI 387

  Fly   447 GFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDELES--ERYHDVKRILLRKDNVMR-LWTY 508
            ...:..|:.....||....::.:::..|..|:.....|.|  :...|.:|.:..:.|::. .|.:
Zfish   388 SSFVEEVKEQFHTHEGYMVELTSHQGSVGRVLKAGSVLLSGGQLTDDEEREVREQMNLLNSRWEH 452

  Fly   509 LLELLRARRMRL-EISLQLQ-QNFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEA 571
            |......|:.|| |:.:.|| |..:::...||..|...:.:.....|..|..::..:::..|::.
Zfish   453 LRVASMERQSRLHEVLMDLQHQQLKQLSDWLDTTETRIKRMGAQALGPELDDIKRQIEEQKLLQE 517

  Fly   572 D-------INILGERVKVVVQNSQKFLSDDPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRS 629
            |       :|.|...|.||.:||    .|...:       .:..::|.|.:.:|.:.:...||..
Zfish   518 DLELEQVRVNSLTHMVVVVDENS----GDGATA-------ALEEKLQNLGERWAAICKWTEERWI 571

  Fly   630 RLEESRKLWQFYWDTADE----ENWIKEKEQIVSTDEVG--HDLTTVNLMLSKHKALESEITSHD 688
            .|::....||.:   ::|    ::|:.:||::|.:.:..  :|...|...|.|...|::::....
Zfish   572 LLQKILLCWQHF---SEEQLLFDSWLTQKEELVQSIQSSGTNDPNEVAANLRKLAILKADLELKR 633

  Fly   689 PQLQNVAKVGSELIT--EGHFGADRIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLFADAD 751
            ..:..:..:..:|:|  :....|.:::.:|:....:||.|:...:....::...|...|     .
Zfish   634 QTMDKLCSLVQDLLTNIKSKEAAGKLEAKLERFAQRWDKLVQALQLTSTKISTIVTTSQ-----S 693

  Fly   752 DVDNWMLDTLR----------------------------IVSSE-----DVG---------RDEA 774
            ::.:..:.|:.                            :|.||     ||.         |.||
Zfish   694 EITHTTMATVTKVTTNQKKMVKHTKEGMSTPPPQKKRQIVVDSELRKRFDVDFTEIHSFMTRSEA 758

  Fly   775 NVQ----SLLKKHKDVADELKNYAEVIDALHKQAESL-KLNEAEK---ANVDKRLEAIDNRYKEL 831
            .:|    |:.:|...|||   .|.:|:....::.|.. ||.||.:   |.|| :|.:.....:::
Zfish   759 VLQNPEFSISRKEGSVAD---LYEKVLAIDREKPEKFRKLQEATRSAQALVD-QLTSDGQNSEDI 819

  Fly   832 TELAKLRKQRLLD-----------------ALSLYKLMSE----ADGVEQWIKEKTKMLDTMTPG 875
            .:.|:..:.|.:|                 .|:.|.|..:    |...|.|:|.::      .|.
Zfish   820 QQAAQQLRARWVDFCALLAERLAWLAYQTKVLAFYNLFQQLEQAAATAENWLKVQS------PPA 878

  Fly   876 KDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHPN---SDEILERQNHLNQEWSTL 937
            .:.|.:.|...|.......::|...:||.:::...:|...|...   ..:|...|.|.:|....|
Zfish   879 CEPEPLRIQLERCRDEISRLSALQPQVAKLHEQLEELRQKEETPVLFDADISAFQEHYHQVLEDL 943

  Fly   938 REKAE-----------AKMDDLKSAHGVQTFYIECRETISWIE--DKKRILTETDSLEMDLTGVM 989
            |.:..           |:..|:.:|            .::|::  :.|..:..|     .:|...
Zfish   944 RARERQLVLVQSSLPPARYKDVMAA------------LLAWLQQCENKLAIPST-----AVTEYP 991

  Fly   990 TLQRRLSGMDRDLAAIQAK-------LSSLEREANSI-EDEHPEEAKIIRERIAQIELIWEQLTQ 1046
            .:::||    :|:.||||.       :..|.:.|..: :...||..:..|..:..:.:.|.::::
Zfish   992 VMEQRL----KDIKAIQASQKEHQGDVDDLNKMAEQVFQKAPPEICQKYRTELDNVMVRWRRISE 1052

  Fly  1047 MLKERDSKLEE-AGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEA---EKLLNQHQSIREE 1107
            .|:|...||:: ...|.:|..|....|.|:  .:.||...:...:|.:|   ||.|.|..::..:
Zfish  1053 QLEENIQKLQDHMTKLQQFQNDTKTLQKWM--AEVDVFLNEEWPALGDAEALEKQLEQCTALVND 1115

  Fly  1108 IDNYTEDYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQ 1172
            |.........:.|.|..|..|..|   |..:.:::.|:.|...||.:.:....::..|...||..
Zfish  1116 IHTVQPSLNGINEVGLALKREAET---PFAIKIQKMLDELNAQWELICKQAYAKKSALKGGLDMT 1177

  Fly  1173 LFNRDARQ--TEVLLSQQEHFLSKD---DTPVNLEQAENQLKR---------------------- 1210
            :..|...|  .|.:...:|.:|.:|   .||..|.:|..:|||                      
Zfish  1178 VSLRKEMQEMQEWITQAEEEYLERDFQYKTPEELHKAVEELKRAQEEVHQKETKVKLLTDKVTNF 1242

  Fly  1211 --------HEAF---LTTMEAN--------DDKINTLLQV----ADTL--VEKDHFDADKIGKRA 1250
                    |:|.   |..:.:|        |.|..||.:|    .:.|  :|.::...|.:.|:.
Zfish  1243 ISKAPPAAHDALKAELDVLTSNYQRLCSRLDGKCKTLEEVWACWCELLSYLELENAWMDLLEKKL 1307

  Fly  1251 ENITGRRD-----DNRQRALD----QH-EKLKNQVK-LHEFLQD---LEELAEWVQEKYATSQDE 1301
            :...|.:.     :....:||    :| |..:||:: |.:.|.|   |:||.....|.|.|..||
Zfish  1308 DETEGLQGGIEEIEEALTSLDTMIREHPEYNRNQIRELAQTLMDGRVLDELIHKKVEDYNTRWDE 1372

  Fly  1302 SYRSA--------KTIHSKW----------------TRHQAFEAEIAANKERLFEAEKSAQELSK 1342
            ..:.|        |::|  |                |..:...|.||..    .:|.:..||..|
Zfish  1373 LMQRASQRRQQLEKSLH--WAQENDKTLRLIQDSLNTTDRHLTAYIADG----IDAAQIPQEAQK 1431

  Fly  1343 EKPEFKDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREVLVQ--------QTCDDIDSYITDL 1399
            .:.|... .|..|.::.|:  .:||...||.....||..:.|:|        |...:.|..:.:.
Zfish  1432 IQTELNG-HEVTLDDMKKK--AMEVDASEKVIGEIDATLDKLLQVKGKFRLFQKPANFDQRLREC 1493

  Fly  1400 EKQIVSGDTANDLTSVNILMQKQQVIQTQM-----------AVKARQVEEIDKQTEYLQKTVPEE 1453
            |:  |..:....|..::|...:|:|:|:|:           .||: :||.:.|....:.:....|
Zfish  1494 ER--VLEEVKVKLGVLSIRSVEQEVVQSQLEQCMKFYKNLSEVKS-EVETVIKTGRQIVQKQQTE 1555

  Fly  1454 KIEPIVVKKTAVLERFEKIKAPLLERQKALEK--------KKEAFQFCR---------------- 1494
            :.:.:..:.||:...:..:.:.:.|.::.|||        :||......                
Zfish  1556 QPKELDDRLTALKLAYNDLGSQVTEGKQELEKILKLLRKFRKEVNSLTEWLATTDGELTRRSSVE 1620

  Fly  1495 ----DVEDEKLW-----------------------------------IDEKLPVANSP------- 1513
                |::.|..|                                   ||:|:.:.|..       
Zfish  1621 GMPSDLDAELAWAKAAQEDTEHHKPQLKLVRELAGTLKGLLHSQENLIDDKVSLLNCNWIAVTSR 1685

  Fly  1514 ---------DYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAKKFEALIS 1569
                     ||.|.:   ..|::....:.|.:|..|.:::.:.:.|            ..|.:|.
Zfish  1686 SEQWLKLLLDYQNQM---KTLEQNISQINTWMDRAEEKLDEMDSQG------------CIEHVIK 1735

  Fly  1570 DLTQKWQELK-----------DAIENRRKHLL-----ESEKVQQYF-----------FDAQEAES 1607
            .|..:.:|:|           |.|:|..:|..     :.|::.|.|           ..:||.:.
Zfish  1736 GLRMELEEMKGKVEAVQVLAEDLIKNTGEHCKAQVKPKLEQLNQRFDIVARRILMGQASSQELDE 1800

  Fly  1608 WMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSV--EDYANTIRQLGE-VARQFSGDDISSGDA 1669
            :..:..:::.|.|   :||.....:|:.:.||.:.  |:..|.:...|| :.::..|.:  ..:|
Zfish  1801 YHRQANIWLQVLD---EEIKLGESLKEEDFLEDATIDEEALNELFLKGENLLKRTPGGE--KREA 1860

  Fly  1670 VAVKQSQLDKLYAGLKDLAGERRAR-LNEALQLFMLSREVDDLEQWI-----TDREVVAGSQE-- 1726
            |..|.:.|...|..||:|...|:.: |..|.|.:...::.||:.||:     :.||:....:|  
Zfish  1861 VREKHNLLHDRYDTLKNLRALRKKKALALASQWYQFCKKSDDMMQWLDRIEKSIRELPDPPEEPR 1925

  Fly  1727 ---LGQDFDHVTLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNESW 1788
               :|.:.|......|......|.....|..|:.:...:..|........:.|....|..|    
Zfish  1926 VKAVGYEIDQQRPKLEDLRGLGRVLSEGGASRMVEPRLLPINKRWTELDVNFTRVRHKSEL---- 1986

  Fly  1789 QDLLELIETRTQMLAASRELHKFF------HDCKDVLGRILEKQHG-VSDELGRDA-----GSVS 1841
            |.||:.|.....:|.:.......|      ..|...:...|:|..| |::.:||.|     |.:.
Zfish  1987 QFLLQCISENEALLNSPERWSTAFINLPQQEKCLKEVKVNLDKLEGPVAEAVGRGASQPEEGLLV 2051

  Fly  1842 TLQRKHYNFL----QDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQAM-C 1901
            .|.|.::..|    ||.:....:.::..|| .|:.|.:..|..:.|...||:.::..|:|:.: .
Zfish  2052 QLLRTNWENLKMLYQDRLKRLEKAKKFNEE-LKMLDNWLTDAERTIMKYEQDPINNRDHLKELQA 2115

  Fly  1902 DARKQKLA-----------------DTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVEL 1949
            ...||:.|                 |..|..: ..:..|...|.:  |....|..|.|......|
Zfish  2116 GLEKQEAAVKGLNALGTDLSPQCSKDDRDHIK-QQLASINSRWAK--VSNQLTEIKRRSAGAKML 2177

  Fly  1950 L------MNNHQSLKAEIDT---------REDNFGACISLGK----ELLTR-------NHYASAD 1988
            |      |...||...:.:.         |::...|.:...|    ||.:|       |...|:.
Zfish  2178 LAELNEDMGEFQSWLDDAEAVAALPVEAGRKEQLSATLEKVKARVVELPSRKQALHQINSKGSSL 2242

  Fly  1989 IKDRLMTLSNSRNALLRRW----------EERWENLQLILEVYQFARDAAVAEAWL------IAQ 2037
            ..|::..|......:..||          :.:.|:|...|.:||  ...:....|.      :.|
Zfish  2243 PADKVKPLEKQLKVINMRWAKVSTDLPEKQRQIEDLLRDLSLYQ--EQLSKLSIWASNTKTQLEQ 2305

  Fly  2038 EPYLLSSELGHTIDE----VENLIKKH-------------------------------------- 2060
            .|..:..::...:.|    ||.|:.|.                                      
Zfish  2306 SPTAVDPKIEDDVKEKKPAVETLLAKERPPCQPEKGQYDGLSADWTSIQVLLKDWKDKCQLAAVT 2370

  Fly  2061 -----------EAFEKSAAAQEERFSALERLTTF---------ELKEMKRRQELAEEAERQRIKE 2105
                       :.|.||....::..:.|:.:...         |:.||..:.:.|.:...||..:
Zfish  2371 LTGSAAGDAALDKFNKSWTELDDWLALLDHMVQTQRVMVGDLDEINEMTVKLKSALQDMEQRCPQ 2435

  Fly  2106 EQEAKAASEAAEQAKREAERR----DDVDVGASH-DDSAAKDTAVEFERVVEIQTERGGTPGAGE 2165
            ..:...|::..:......|.|    |.::...:| :||.||.||    ||:.:|       ...:
Zfish  2436 LNKQITAAQNLKNKTNNPETRATITDRIEKLQAHWEDSHAKLTA----RVLTLQ-------NMYK 2489

  Fly  2166 GHEGYVTRKHEWDSTTKKASNR--SWDKVYMAAKAGRISFYKDQKGYKSNPELTFRGEPSYDLQN 2228
            ....::..:...:...|||:.:  ||.||..:.        :|.||                 ||
Zfish  2490 DSSDWLEARKRVEPLIKKANEKLESWKKVSHSV--------EDLKG-----------------QN 2529

  Fly  2229 AAI-EIASDYTKKKHVLRV--KLANGALFLLQAHDDT----EMSQ-----WVTSLKAQSDSTA 2279
            |.: :::.|..:.:..:.|  :||| .|..|.|.|||    :|::     |....|...|..|
Zfish  2530 ADVKQLSKDLQQWQTQMNVTNELAN-KLLTLYADDDTSKVKQMTESMNLAWANIKKRAGDKEA 2591

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 52/98 (53%)
CH 170..269 CDD:278723 51/99 (52%)
Spectrin 298..408 CDD:278843 18/126 (14%)
SPEC 422..521 CDD:197544 21/103 (20%)
SPEC 525..740 CDD:238103 43/230 (19%)
SPEC 639..846 CDD:238103 49/281 (17%)
SPEC 848..1058 CDD:238103 45/238 (19%)
SPEC 955..1169 CDD:238103 46/227 (20%)
SPEC 1170..1380 CDD:238103 66/299 (22%)
SPEC 1386..1484 CDD:197544 20/116 (17%)
SPEC 1488..1699 CDD:238103 52/312 (17%)
SPEC 1594..1806 CDD:238103 50/236 (21%)
SPEC 1807..2015 CDD:238103 54/277 (19%)
Spectrin 2018..>2078 CDD:278843 14/118 (12%)
PH 2167..2275 CDD:278594 27/121 (22%)
PH_beta_spectrin 2167..2274 CDD:269975 27/120 (23%)
dmdNP_001313616.1 CH 33..136 CDD:237981 55/103 (53%)
CH 152..257 CDD:237981 53/122 (43%)
SPEC 359..577 CDD:238103 50/239 (21%)
SPEC 580..844 CDD:238103 50/275 (18%)
SPEC 741..950 CDD:238103 47/218 (22%)
SPEC 856..1063 CDD:238103 44/233 (19%)
SPEC 1067..1281 CDD:238103 48/218 (22%)
SPEC 1180..1388 CDD:238103 46/207 (22%)
SPEC 1486..1586 CDD:197544 18/102 (18%)
SPEC 1591..1788 CDD:238103 29/211 (14%)
SPEC 1823..1973 CDD:295325 34/151 (23%)
SPEC 2074..2279 CDD:238103 39/208 (19%)
SPEC 2381..2595 CDD:238103 53/248 (21%)
SPEC 2599..2841 CDD:238103
SPEC 2843..>2962 CDD:295325
WW <2973..2995 CDD:238122
EF-hand_2 2997..3114 CDD:286194
EF-hand_3 3118..3209 CDD:286195
ZZ_dystrophin 3218..3266 CDD:239074
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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