DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and Sptbn4

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_006540500.1 Gene:Sptbn4 / 80297 MGIID:1890574 Length:2580 Species:Mus musculus


Alignment Length:2554 Identity:1025/2554 - (40%)
Similarity:1436/2554 - (56%) Gaps:292/2554 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 RWD-PSQGPGNEYIDEYEYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRIA 72
            ||: |.:|     .|.......|:::.|||.|||||||:|||:||||||||||||||.||.|.|.
Mouse    44 RWESPDRG-----WDREPPAAANAAASLFECSRIKALADEREAVQKKTFTKWVNSHLARVGCHIG 103

  Fly    73 DLYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDG 137
            |||.|:|||..|.:||||||||:||:||:|:||||.|||||||||||:||||||||:||||||||
Mouse   104 DLYADLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDG 168

  Fly   138 NASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGL 202
            |..|.|||:||||||||||.|.||..||:||:|||||||||||||||||..||::||||||||||
Mouse   169 NHRLTLGLVWTIILRFQIQVIKIETEDNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGL 233

  Fly   203 AFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVV 267
            ||||:||:||||||...||:|:||.:||..||..||..||||:|||.|||.:|.|||||||||||
Mouse   234 AFNALIHRHRPDLVDLSKLTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVV 298

  Fly   268 TYYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAG 332
            ::||||||:|...|:|||||||:...:|.||::..||...::||.||..|:..:..::|.|||:|
Mouse   299 SFYHYFSKMKALAVEGKRIGKVLDQVLEVDKIIERYEELAAELLAWIHRTVDLISNQKFANSLSG 363

  Fly   333 VQGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEK 397
            ||.||..|:.|.|:|||.||.||||||||||::|||:||:|::.:.|:||..|.||:|||..|||
Mouse   364 VQQQLQAFTAYCTLEKPVKFQEKGNLEVLLFSIQSKLRAHNRRLFVPREGCGIWDIDKAWGELEK 428

  Fly   398 AEHERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEA 462
            ||||||.|||.|||||||||.||.|||.|.:|||:||:||||||||||||::|.|||||.|||||
Mouse   429 AEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEA 493

  Fly   463 IETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQ 527
            ||.||.|||||||.|..:...|.:|.|:|.:|:..::|:|:|.|..|..|:.|||.|||.:|.||
Mouse   494 IEADIAAYEERVQGVAELAQALAAEGYYDARRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQ 558

  Fly   528 QNFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLS 592
            :.||||:|::|.|||::..|::.:.|:||:..:||||||.|:|.||....|||:.:  |:.....
Mouse   559 KVFQEMVYMVDWMEEMQTQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEAL--NAAALRF 621

  Fly   593 DDPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQI 657
            ...:.|:||||::|.:||..:....:||...|..||:.||.||.||....:..:.|:|.::||::
Mouse   622 SQLQGYQPCDPQVICNRVNHVHGCLSELQEQAARRRAELEASRSLWALLQELEEAESWARDKERL 686

  Fly   658 V-STDEVG---------HDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHF---GA 709
            : :|...|         |||::...:|::||.|:.|:......||...:.|.||...|..   ||
Mouse   687 LEATSGSGGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRRGEELAAAGGSVGPGA 751

  Fly   710 D-----RIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDV 769
            :     .:.:|......:|..|.:....|.:||:.|....|..||.|.:.:|:.|..|:.::.|.
Mouse   752 EPLHLAGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDF 816

  Fly   770 GRDEANVQSLLKKHKDVADELKNYAEVIDALHKQAESLKLNEAEKAN-----VDKRLEAIDNRYK 829
            |.|||:.:.|.::|:.:..|::.:...:..|.:|..:  |..|..|.     :..|:...:..:.
Mouse   817 GHDEASSRRLARQHRALTGEVEAHRGPVGGLRRQLAT--LGGASGAGPLVVALQVRVVEAEQLFA 879

  Fly   830 ELTELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKE 894
            |:||:|.||:|.|.|||::|::..|....|.||.||.:.|..|.....::|||:::||||..|:|
Mouse   880 EVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLAMRVPDSLDDVEVVQHRFESLDQE 944

  Fly   895 MNANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYI 959
            ||:...||..|||..::|:...||:|||:...|:|||..|:.:.|..|.:.:::.:...|:...:
Mouse   945 MNSLMGRVLDVNQTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVL 1009

  Fly   960 ECRETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHP 1024
            |..|..:.:.:|:|      ::|........||.||||::..|.|::.:.::|..||..:.:..|
Mouse  1010 EVAEVRAQVREKRR------AVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFP 1068

  Fly  1025 EEAKIIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASED--T 1087
            .:|..:.:...::...|..|....:.....:..||.|.|||||||.|..||.:.|....:.:  .
Mouse  1069 AQATRLHQGAEELGAEWGALAGAAQACGEAVAAAGRLQRFLRDLDTFLDWLVRAQEAAGAVEGPL 1133

  Fly  1088 PTSLPEAEKLLNQHQSIREEIDNYTEDYKNMMEYGER-LTSEGSTSDDPQYMFLRERLNALKDGW 1151
            |.||.||:.||.:|.:::||:|...|||..::...|. |.|||:.....  :.|.|.|..|:.||
Mouse  1134 PRSLEEADGLLARHAALKEEVDQREEDYARIVAASEALLASEGAELGPG--LALDEWLPHLEVGW 1196

  Fly  1152 EELHQMWENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLT 1216
            .:|..:||.|:..|.|:...|||.||..|...:|..||..||..:.|..:|..|..:|||..|||
Mouse  1197 HKLLGLWEERREALVQAHVYQLFLRDLCQALAVLRNQEVALSGAELPCTVESVEEAMKRHRDFLT 1261

  Fly  1217 TMEANDDKINTLLQVADTLVEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFL 1281
            |||.|..|:...:|.|::|:.:.:...::..:....:..:..:|:.||....:||.:|:.|..||
Mouse  1262 TMELNQQKMQVAVQAAESLLRQGNAYGEQAQEAVARLLEKSQENQLRAQQWMQKLLDQLVLQHFL 1326

  Fly  1282 QDLEELAEWVQEKYATSQDESYRSAKTIHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPE 1346
            :|..||..|:.||...::|.:...:..:|.:|.|||||.||:|.|||.|.:.|:..|:|.:||||
Mouse  1327 RDCHELDGWIHEKMLMARDGTREDSHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPE 1391

  Fly  1347 FKDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTAND 1411
            ....:..||.|:.:.:.:||..|:.|...||:|::...:.|:..::|..:..:|.|:...|...|
Mouse  1392 LAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKRLLHMESQLQDVDPGGD 1456

  Fly  1412 LTSVNILMQKQQVIQTQMAVKARQVEEIDKQTEYLQKTVPEEKIEPIVV--KKTAVLERFEKIKA 1474
            |.:||..::|.|.:::|:....|:|.|:..||..|    |.|:....:|  :::||.||..::..
Mouse  1457 LATVNSQLKKLQSMESQVEEWCREVGELQAQTAAL----PLEQASKELVGERQSAVGERLVRLLE 1517

  Fly  1475 PLLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNH 1539
            ||.||::.|...||..|...|::||..|:.|:||:|...:.|..|..|....||||.|..||..|
Mouse  1518 PLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGTGLQAVQQHIKKNQGLRREIQAH 1582

  Fly  1540 EPRINAICNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQE 1604
            .||:..:......|......:|:........|...|..|::|.|.|::.|..:.:|:||:||..|
Mouse  1583 GPRLEEVLERAGVLASLRSPEAEAVRRGQEQLQSAWTGLREAAERRQQTLDAAFQVEQYYFDVAE 1647

  Fly  1605 AESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDA 1669
            .|:|:.||||.||.||:||||.|...|:|||..|||.||:|..:|.||....|..........:.
Mouse  1648 VEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 1712

  Fly  1670 VAVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHV 1734
            ::.:|||:|:||..||:|..|||..|.:...|:.|||:||:||.||.::||||||.||||||:||
Mouse  1713 ISRRQSQVDRLYVALKELGEERRVSLEQQYWLYQLSRQVDELEHWIAEKEVVAGSPELGQDFEHV 1777

  Fly  1735 TLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNESWQDLLELIETRT 1799
            ::|.|:|:|||.:|...|.||:|.||.:.|.||:.||:.:||:|||||.|||:|.:||||:.||.
Mouse  1778 SVLQEKFSEFASETGTAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRA 1842

  Fly  1800 QMLAASRELHKFFHDCKDVLGRILEKQHGVSDELGR------DAGSVSTLQRKHYNFLQDLITLY 1858
            |:|||||||||||.|.:::.|:|.||:.    .|.|      ...|.|::||....|..||..|.
Mouse  1843 QLLAASRELHKFFSDARELQGQIEEKRR----RLPRLTAPPEPRPSASSMQRTLRAFEHDLQLLV 1903

  Fly  1859 SQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKLADTGDLFRFFNMVRI 1923
            |||:|:||.:|:|:..|||:.|:.|.:||||||..|..|.|.|:..:..::.|.|..||.:..|.
Mouse  1904 SQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLAACEDARLHVSSTADALRFHSQARD 1968

  Fly  1924 LMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYASAD 1988
            |:.||:.:..|:..::||||||.||:|||.||.||.|::.|......|..||:.||......:.:
Mouse  1969 LLSWMDGIAGQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELATCQELGRSLLLNKSAMADE 2033

  Fly  1989 IKDRLMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPYLLSSELGHTIDEV 2053
            |:.:|..|.:.:..:..:|:..||.||.:|||:|||::|.||:|||.||||.|.|.|||.::|||
Mouse  2034 IQAQLDKLGSRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEV 2098

  Fly  2054 ENLIKKHEAFEKSAAAQEERFSALERLTTFE-LK------------------------------- 2086
            |.||::||||.|:|||.|||||:|.||||.| ||                               
Mouse  2099 EQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKLKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLL 2163

  Fly  2087 ---------------------------------EMK----------------------------- 2089
                                             |:|                             
Mouse  2164 RPGGYDRGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPETSGKVEPAAPTAAALD 2228

  Fly  2090 ------------------RRQELAEEAE---RQRIKEEQEAKAASEAAEQAKREAERRDDVDVGA 2133
                              .|||||:.||   |:|..|.||:....|...: :|..||::..|...
Mouse  2229 TTDTPGTPAATELVRPRSERQELADRAEELPRRRRSERQESVDQPEETAR-RRRPERQESADHEG 2292

  Fly  2134 SH-----------------------DDSAAKDTAVEFERV---------VEIQTERGGTPG---- 2162
            .|                       .:|:.::|....|.|         ||...|:...||    
Mouse  2293 PHSLTLGRYEQMERRRERRERRIERQESSEQETPTRGELVKGKATLADIVEQLQEKEAGPGIPAG 2357

  Fly  2163 -----------------------------------------------AGEG-------------- 2166
                                                           .|||              
Mouse  2358 VPSLPQPRELPPGRLPNGLEPPERTPRPDRPRARDRPKPRRRPRPREGGEGGGSRRSRSAPAQGG 2422

  Fly  2167 --------------HEGYVTRKHEWDSTTKKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPELT 2217
                          |||::.||.|.|: .:|:|||||..:|.....|.:.||||.||..|..  |
Mouse  2423 SAPAPPPPPTHTVQHEGFLLRKRELDA-NRKSSNRSWVSLYCVLSKGELGFYKDSKGPASGG--T 2484

  Fly  2218 FRGEPSYDLQNAAIEIASDYTKKKHVLRVKLANGALFLLQAHDDTEMSQWVTSLKAQSDSTAVAA 2282
            ..|||...|..|..|:||||.|||||.:::..:|:.|||||.|:.||:.|:.::.......|..|
Mouse  2485 HGGEPLLSLHKATSEVASDYKKKKHVFKLQTQDGSEFLLQAKDEEEMNGWLEAVANSVAEHAEIA 2549

  Fly  2283 SRSQTLPATSQKDE--PKR 2299
            ...||||.||..||  |||
Mouse  2550 RWGQTLPTTSSTDEGNPKR 2568

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 76/97 (78%)
CH 170..269 CDD:278723 74/98 (76%)
Spectrin 298..408 CDD:278843 61/109 (56%)
SPEC 422..521 CDD:197544 59/98 (60%)
SPEC 525..740 CDD:238103 76/232 (33%)
SPEC 639..846 CDD:238103 59/229 (26%)
SPEC 848..1058 CDD:238103 59/209 (28%)
SPEC 955..1169 CDD:238103 65/216 (30%)
SPEC 1170..1380 CDD:238103 74/209 (35%)
SPEC 1386..1484 CDD:197544 29/99 (29%)
SPEC 1488..1699 CDD:238103 80/210 (38%)
SPEC 1594..1806 CDD:238103 111/211 (53%)
SPEC 1807..2015 CDD:238103 81/213 (38%)
Spectrin 2018..>2078 CDD:278843 40/59 (68%)
PH 2167..2275 CDD:278594 48/107 (45%)
PH_beta_spectrin 2167..2274 CDD:269975 48/106 (45%)
Sptbn4XP_006540500.1 SAC6 75..>423 CDD:227401 236/347 (68%)
SPEC 450..664 CDD:238103 108/215 (50%)
SPEC 790..1002 CDD:238103 70/213 (33%)
SPEC 1106..1210 CDD:197544 40/105 (38%)
SPEC 1216..1424 CDD:238103 74/207 (36%)
SPEC 1322..1529 CDD:238103 71/210 (34%)
SPEC 1531..1742 CDD:238103 80/210 (38%)
SPEC 1637..1849 CDD:238103 111/211 (53%)
Spectrin 1849..1948 CDD:334073 45/102 (44%)
SPEC 1958..>2125 CDD:238103 79/166 (48%)
PH_beta_spectrin 2437..2541 CDD:269975 48/106 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 183 1.000 Domainoid score I3420
eggNOG 1 0.900 - - E2759_KOG0517
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52262
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 1 1.000 - - FOG0000586
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 1 1.100 - - O PTHR11915
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
109.790

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