DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and CLMN

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_011535460.1 Gene:CLMN / 79789 HGNCID:19972 Length:1033 Species:Homo sapiens


Alignment Length:1304 Identity:293/1304 - (22%)
Similarity:460/1304 - (35%) Gaps:424/1304 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 RIKALAEERESVQKKTFTKWVNSHL--CRVNCRIADLYVDMRDGKHLIKLLEVLSGERLPKPTKG 102
            |::.|..|||:|||:|||:|:|.||  |.....:.||:||::|||.|:.|||||||..|....|.
Human    22 RVQNLQVERENVQKRTFTRWINLHLEKCNPPLEVKDLFVDIQDGKILMALLEVLSGRNLLHEYKS 86

  Fly   103 KM-RIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDIT------- 159
            .. ||..|.|:.|||:||.:..|.|.:|.:.:|.|||.||.|||||.|||.|||:::|       
Human    87 SSHRIFRLNNIAKALKFLEDSNVKLVSIDAAEIADGNPSLVLGLIWNIILFFQIKELTGNLSRNS 151

  Fly   160 --------------------------IEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSW 198
                                      ...:..|:.:.|..|||.|.|.||..| .|.|::|..||
Human   152 PSSSLSPGSGGTDSDSSFPPTPTAERSVAISVKDQRKAIKALLAWVQRKTRKY-GVAVQDFAGSW 215

  Fly   199 RDGLAFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSII 263
            |.||||.|:|....|.||..::..:.:...||..||.:|:|.|.:.:||:.||:.|:.|||:||:
Human   216 RSGLAFLAVIKAIDPSLVDMKQALENSTRENLEKAFSIAQDALHIPRLLEPEDIMVDTPDEQSIM 280

  Fly   264 TYVVTYYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFEN 328
            |||..:...|.:|:.|.:            .::||.|.            ||:|...:.|...|.
Human   281 TYVAQFLERFPELEAEDI------------FDSDKEVP------------IESTFVRIKETPSEQ 321

  Fly   329 SLAGVQGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWE 393
                                          |..:|.|..    |.::.||         :|    
Human   322 ------------------------------ESKVFVLTE----NGERTYT---------VN---- 339

  Fly   394 RLEKAEHERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAK 458
                                                                             
Human   340 ----------------------------------------------------------------- 339

  Fly   459 KHEAIETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEIS 523
             ||.        .....:.|.|||:.||.:.       .|.|.|.                   |
Human   340 -HET--------SHPPPSKVFVCDKPESMKE-------FRLDGVS-------------------S 369

  Fly   524 LQLQQNFQEMLY-ILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNS 587
            ..|..:..|.:: |:|.:               |.|........|....:.:||..|.:....||
Human   370 HALSDSSTEFMHQIIDQV---------------LQGGPGKTSDISEPSPESSILSSRKENGRSNS 419

  Fly   588 ---QKFLSDDPESYKP--CDPEII--------VSRVQQLEDAYAELVRLAVERRSRLEESRKLWQ 639
               :|.:..:.::||.  |...:.        |::....:|.:...|.:|.|:..:.|.|:    
Human   420 LPIKKTVHFEADTYKDPFCSKNLSLCFEGSPRVAKESLRQDGHVLAVEVAEEKEQKQESSK---- 480

  Fly   640 FYWDTADEENWIKEKEQIVSTDEVGHDL-----TTVNLMLSK-HKALESEITSHDPQLQNVAKVG 698
                       |.|.    |:|:|..|:     |..|...|. :.|||| ...||.:..:::..|
Human   481 -----------IPES----SSDKVAGDIFLVEGTNNNSQSSSCNGALES-TARHDEESHSLSPPG 529

  Fly   699 SELITEGHFGADRIKDRLK--EILNKWDHL----LDLTKYRRQRLENAVEYFQLFADADDVDNWM 757
            ...:....|   :||..|.  |.|.:.|:.    |..:|:....::        ||......|  
Human   530 ENTVMADSF---QIKVNLMTVEALEEGDYFEAIPLKASKFNSDLID--------FASTSQAFN-- 581

  Fly   758 LDTLRIVSSEDVGRDEANVQSLLKKHKDVADELKNYAE-----VIDALHKQAES----LKLNE-- 811
                ::.|..:...||.            |:..:|:||     .|.:.||:.:|    :|:::  
Human   582 ----KVPSPHETKPDED------------AEAFENHAEKLGKRSIKSAHKKKDSPEPQVKMDKHE 630

  Fly   812 ---------------AEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYKLMSEADGVEQW 861
                           .|:..|||:        .|:.|.||.:..|     ..|:...|.|.: |.
Human   631 PHQDSGEEAEGCPSAPEETPVDKK--------PEVHEKAKRKSTR-----PHYEEEGEDDDL-QG 681

  Fly   862 IKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHPNS---DEI 923
            :.|:   |.:..|...:....:..|..||.|.:.:...|:|:|:........|.|.|.:   :..
Human   682 VGEE---LSSSPPSSCVSLETLGSHSEEGLDFKPSPPLSKVSVIPHDLFYFPHYEVPLAAVLEAY 743

  Fly   924 LERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTGV 988
            :|....|..|...| |:.|..|.||.|.          .|.....:.........:||......|
Human   744 VEDPEDLKNEEMDL-EEPEGYMPDLDSR----------EEEADGSQSSSSSSVPGESLPSASDQV 797

  Fly   989 MTLQRRLSGMDRDLAAIQAKLS------SLEREANSIEDEHPEEAKIIRERIA---QIELIWEQL 1044
            :.|.|  .|:....|:..|.|:      ..|.:.|...|.|..:.....|.||   :..:..|.:
Human   798 LYLSR--GGVGTTPASEPAPLAPHEDHQQRETKENDPMDSHQSQESPNLENIANPLEENVTKESI 860

  Fly  1045 TQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEID 1109
            :...||:             .:.:||.::.|......|.|.|                .:.|:..
Human   861 SSKKKEK-------------RKHVDHVESSLFVAPGSVQSSD----------------DLEEDSS 896

  Fly  1110 NYT----EDYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLD 1170
            :|:    ..:.:...|..|.|...|.||...|:.||   ||.        .:.:.|..:|::...
Human   897 DYSIPSRTSHSDSSIYLRRHTHRSSESDHFSYVQLR---NAA--------DLDDRRNRILTRYST 950

  Fly  1171 QQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRH---EAF-LTTMEANDDKINTLLQV 1231
            |:|       ||::|   :.:..:.|.....:.|...:|.:   ||. |.:.....|.:..|:|.
Human   951 QKL-------TELIL---QFYGIRADMKRESKHARMSMKANSSGEAMSLGSHSPQSDSLTQLVQQ 1005

  Fly  1232 ADTL 1235
            .|.:
Human  1006 PDMM 1009

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 51/100 (51%)
CH 170..269 CDD:278723 44/98 (45%)
Spectrin 298..408 CDD:278843 14/109 (13%)
SPEC 422..521 CDD:197544 11/98 (11%)
SPEC 525..740 CDD:238103 48/240 (20%)
SPEC 639..846 CDD:238103 49/244 (20%)
SPEC 848..1058 CDD:238103 47/221 (21%)
SPEC 955..1169 CDD:238103 41/226 (18%)
SPEC 1170..1380 CDD:238103 15/70 (21%)
SPEC 1386..1484 CDD:197544
SPEC 1488..1699 CDD:238103
SPEC 1594..1806 CDD:238103
SPEC 1807..2015 CDD:238103
Spectrin 2018..>2078 CDD:278843
PH 2167..2275 CDD:278594
PH_beta_spectrin 2167..2274 CDD:269975
CLMNXP_011535460.1 CH 33..134 CDD:278723 51/100 (51%)
CH 191..286 CDD:278723 43/95 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D543832at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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