DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta-Spec and SPTBN2

DIOPT Version :9

Sequence 1:	NP_001259660.1	Gene:	beta-Spec / 32746	FlyBaseID:	FBgn0250788	Length:	2308	Species:	Drosophila melanogaster
Sequence 2:	XP_006718732.1	Gene:	SPTBN2 / 6712	HGNCID:	11276	Length:	2397	Species:	Homo sapiens

Alignment Length:	2367	Identity:	1126/2367 - (47%)
Similarity:	1544/2367 - (65%)	Gaps:	122/2367 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 RIKALAEERESVQKKTFTKWVNSHLCRVNCRIADLYVDMRDGKHLIKLLEVLSGERLPKPTKGKM 104
            |.|.|.:|||:||||||||||||||.||.||:.|||.|:|||::|::||||||||.|||||||:|
Human    54 RFKQLQDEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRM 118

  Fly   105 RIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEVDNKETK 169
            |||||||||||||||:||:|||||:|||||||||..|.|||:||||||||||||::|..||||.|
Human   119 RIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKK 183

  Fly   170 SAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAF 234
            |||||||||||||||||.||||.|||||||||||||||:|||||||:.||.|.|.||.:||.|||
Human   184 SAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAF 248

  Fly   235 DVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYFSKLKQETVQGKRIGKVVGIAMENDKM 299
            ::||.:|||.||||.|||.|:.||||||||||.||||||||:|...|:|||||||:..|||.:::
Human   249 NLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERL 313

  Fly   300 VHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQGQLAQFSNYRTIEKPPKFVEKGNLEVLLFT 364
            |..||:..|:||:|||.||.:|.:|:..|||:|||.||..|::|||:||||||.|||||||||||
Human   314 VEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFT 378

  Fly   365 LQSKMRANNQKPYTPKEGKMISDINKAWERLEKAEHERELALREELIRQEKLEQLAARFDRKASM 429
            :|||:||||||.|||:||::|||||||||||||||||||||||.|||||||||||||||||||:|
Human   379 IQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAM 443

  Fly   430 RETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDELESERYHDVKR 494
            ||||||||||||||||||.:|||||||.:|||||||||.||..|||||.||..||.:|||||:||
Human   444 RETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKR 508

  Fly   495 ILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQNFQEMLYILDNMEEIKQLLMTDDYGKHLMGV 559
            |..|:.||.|||.:|.:::.|||.||.::|:||:.||::||::|.|||:|..|.:.|.|:||.||
Human   509 IAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGV 573

  Fly   560 EDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYKPCDPEIIVSRVQQLEDAYAELVRLA 624
            |||||.|.||||||.:..|||:.|..::.:|.:...| |:||||:::..||.:||.:|..|..||
Human   574 EDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKE-YRPCDPQLVSERVAKLEQSYEALCELA 637

  Fly   625 VERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDEVGHDLTTVNLMLSKHKALESEITSHDP 689
            ..||:||||||:||:|.|:..:.|.|::|::.::::.:.|.|||....:|:||.||..|::....
Human   638 AARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMSGRLG 702

  Fly   690 QLQNVAKVGSELITEGHFGADRIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLFADADDVD 754
            .|:...:.|.:|:.|||.||.:...|..|:..:|:.|..|.:.|.|||..|...:|..|||:|::
Human   703 PLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQFQADANDME 767

  Fly   755 NWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVADELKNYAEVIDALHKQAESLKLNEAEKANVDK 819
            .|::|.||:|||.::|.||.:.|:|.::|:.:.:|::::...:|||.:||.:|....:....|..
Human   768 AWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQS 832

  Fly   820 RLEAIDNRYKELTELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIM 884
            |:..::..|:||...|..|.:.|..||:||.::|||.....|::||.:.|:.:...:.:||:|::
Human   833 RVPTLERHYEELQARAGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVV 897

  Fly   885 KHRFEGFDKEMNANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDDLK 949
            :.|||..:.|||..|:::..||.:|.|||....|..|.|:..|..||..|...|..|:.|...|.
Human   898 QQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALT 962

  Fly   950 SAHGVQTFYIECRETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLER 1014
            ||..:|.:::||.||.:|:.:|.:::..|..|..||.||:.|||:|:|.:|||.||.|::..|.|
Human   963 SALSIQNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTR 1027

  Fly  1015 EANSIEDEHPEEAKIIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQ 1079
            |||::...||.:|..|..|:.:::..||.|...::.|:..|.||..|..|||.||.||.||.:||
Human  1028 EANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQ 1092

  Fly  1080 TDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTEDYKNMMEYGERLTSEGSTSDDPQYMFLRERL 1144
            |.||||:.|.:|||||.||.||.::|.|::....:|..:...||.:|.:.:   |||.:|||:||
Human  1093 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQA---DPQCLFLRQRL 1154

  Fly  1145 NALKDGWEELHQMWENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLK 1209
            .||..|||||.:|||:||..|:|:...|.|.|||||.|.:||.||:.||..:.|..|:.|:..:|
Human  1155 EALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQAADAAIK 1219

  Fly  1210 RHEAFLTTMEANDDKINTLLQVADTLVEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLKNQ 1274
            :.|.|::||:||.::|:.||:....||.:.:..||||.::|::|..|...|:..|.....:|::.
Human  1220 KLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDN 1284

  Fly  1275 VKLHEFLQDLEELAEWVQEKYATSQDESYRSAKTIHSKWTRHQAFEAEIAANKERLFEAEKSAQE 1339
            .:...||||..||..|:.||..|:||.||..|:.:|:||.:||||.||:||||:.|.:.:|..:|
Human  1285 REQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRE 1349

  Fly  1340 LSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIV 1404
            |:.||||.|.::..||::|.:::|:||..|:.|...||||||..|..|:|..::|::..|:.|:.
Human  1350 LTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLH 1414

  Fly  1405 SGDTANDLTSVNILMQKQQVIQTQMAVKARQVEEIDKQTEYLQKTVPEEKIEPIVVKKT--AVLE 1467
            |.|...||||||||::|||:::.:|||:.::||.|..|.    |.:.:|......|::|  ||.|
Human  1415 SDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQA----KALAQEDQGAGEVERTSRAVEE 1475

  Fly  1468 RFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSL 1532
            :|..:..|:.||.:.|:..:|..||.||||||.||:.|:||:|:|.::|..|.:|.:|.||||:|
Human  1476 KFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTL 1540

  Fly  1533 ATEIDNHEPRINAICNNGRKL--IDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKV 1595
            ..||..|||||..:....|.|  ...|.|        :::|.:.|:.|...:|.|.|.|.::.:.
Human  1541 QKEIQGHEPRIADLRERQRALGAAAAGPE--------LAELQEMWKRLGHELELRGKRLEDALRA 1597

  Fly  1596 QQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVARQFS 1660
            ||::.||.|||:||.||||:||.:::.|||:|||..:|||:.|||::.|||.||.||...::...
Human  1598 QQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMI 1662

  Fly  1661 GDDISSGDAVAVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQ 1725
            ..:......::::|:|:||||||||:||||||.||.|.|:|..|.||:|||||||.:|||||.|.
Human  1663 DHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASH 1727

  Fly  1726 ELGQDFDHVTLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNESWQD 1790
            |||||::|||:|.::|.||:|||..:|.|||...|.:|:.||..||:..||:|||||:|||:|.|
Human  1728 ELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWAD 1792

  Fly  1791 LLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGVSDELGRDAGSVSTLQRKHYNFLQDLI 1855
            ||||::||.|:|||:.||.:|.|..:..|.|:..||..:.|..|||..:...|||:|..:..|:.
Human  1793 LLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQ 1857

  Fly  1856 TLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKLADTGDLFRFFNM 1920
            .|..||||:|::..:||.|||||||:||....|.|..||..||....||:|.|.||.|.||||..
Human  1858 ALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKA 1922

  Fly  1921 VRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYA 1985
            ||.||:||:::..||:..|:|||||..:|::.|.|.:||||:.|.|.|.:||.:|||||.|:|||
Human  1923 VRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYA 1987

  Fly  1986 SADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPYLLSSELGHTI 2050
            :.:|.::|..|...|.....:|:|:.:.|||:|||..|.|||.:|||||.:|||.:.|:|||.|:
Human  1988 AEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTV 2052

  Fly  2051 DEVENLIKKHEAFEKSAAAQEERFSALERLTTFELKEMKRRQELAEEAER--------------- 2100
            ||||:|||:||||:|||.|.||||.|||:||..|.:|.:|:::..||..|
Human  2053 DEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPEPTASVPPG 2117

  Fly  2101 ---------------------------------------------QRIKE----EQEAKAASEAA 2116
                                                         ||::.    |.....:.:.|
Human  2118 DLVGGQTASDTTWDGTQPRPPPSTQAPSVNGVCTDGEPSQPLLGQQRLEHSSFPEGPGPGSGDEA 2182

  Fly  2117 EQAKREAERRDDVDVGASHDDSAAKDTAVEFERVVEIQTERGGTPGAGEGHEGYVTRKHEWDSTT 2181
            ...:.|.:.|......::...|.:.::|     .......||..|.|.|..||.:.||.|.::..
Human  2183 NGPRGERQTRTRGPAPSAMPQSRSTESA-----HAATLPPRGPEPSAQEQMEGMLCRKQEMEAFG 2242

  Fly  2182 KKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPELTFRGEPSYDLQNAAIEIASDYTKKKHVLRV 2246
            |||:||||..||...:.|.:.||||.|.  ::..:.:.||....|..|...:|.||.|:|||.::
Human  2243 KKAANRSWQNVYCVLRRGSLGFYKDAKA--ASAGVPYHGEVPVSLARAQGSVAFDYRKRKHVFKL 2305

  Fly  2247 KLANGALFLLQAHDDTEMSQWV--------TSLKAQSD-------STAVAASRSQTLPATS---- 2292
            .|.:|..:|.||.|:.|||.|:        |:..|..:       ||....:|:.|:|..|
Human  2306 GLQDGKEYLFQAKDEAEMSSWLRVVNAAIATASSASGEPEEPVVPSTTRGMTRAMTMPPVSPVGA 2370

  Fly  2293 ------------QKDEPKRRSFFTLKK 2307
                        :::..||.|||...|
Human  2371 EGPVVLRSKDGREREREKRFSFFKKNK 2397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta-Spec	NP_001259660.1	CH	51..149	CDD:278723	78/97 (80%)
		CH	170..269	CDD:278723	77/98 (79%)
		Spectrin	298..408	CDD:278843	78/109 (72%)
		SPEC	422..521	CDD:197544	71/98 (72%)
		SPEC	525..740	CDD:238103	91/214 (43%)
		SPEC	639..846	CDD:238103	66/206 (32%)
		SPEC	848..1058	CDD:238103	77/209 (37%)
		SPEC	955..1169	CDD:238103	96/213 (45%)
		SPEC	1170..1380	CDD:238103	87/209 (42%)
		SPEC	1386..1484	CDD:197544	36/99 (36%)
		SPEC	1488..1699	CDD:238103	96/212 (45%)
		SPEC	1594..1806	CDD:238103	118/211 (56%)
		SPEC	1807..2015	CDD:238103	92/207 (44%)
		Spectrin	2018..>2078	CDD:278843	40/59 (68%)
		PH	2167..2275	CDD:278594	43/115 (37%)
		PH_beta_spectrin	2167..2274	CDD:269975	42/114 (37%)
SPTBN2	XP_006718732.1	CH	68..166	CDD:214479	78/97 (80%)
		CH	184..287	CDD:237981	81/102 (79%)
		Spectrin	312..421	CDD:278843	77/108 (71%)
		Spectrin	436..529	CDD:278843	67/92 (73%)
		SPEC	541..753	CDD:238103	90/212 (42%)
		SPEC	756..965	CDD:238103	72/208 (35%)
		SPEC	968..1179	CDD:238103	96/213 (45%)
		SPEC	1181..1390	CDD:238103	87/208 (42%)
		SPEC	1391..1595	CDD:238103	82/215 (38%)
		SPEC	1596..1808	CDD:238103	118/211 (56%)
		SPEC	1809..2017	CDD:238103	92/207 (44%)
		SPEC	2025..>2082	CDD:197544	39/56 (70%)
		PH_beta_spectrin	2228..2331	CDD:269975	41/104 (39%)
		PH	2228..2331	CDD:278594	41/104 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I3245
eggNOG	1	0.900	-	-		E2759_KOG0517
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2488	1.000	Inparanoid score	I31
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52262
OrthoDB	1	1.010	-	-		D15759at33208
OrthoFinder	1	1.000	-	-		FOG0000586
OrthoInspector	1	1.000	-	-		otm41171
orthoMCL	1	0.900	-	-		OOG6_100348
Panther	1	1.100	-	-	O	PTHR11915
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3302
SonicParanoid	1	1.000	-	-		X1255
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870