DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment beta-Spec and SPTBN1

DIOPT Version :9

Sequence 1:	NP_001259660.1	Gene:	beta-Spec / 32746	FlyBaseID:	FBgn0250788	Length:	2308	Species:	Drosophila melanogaster
Sequence 2:	NP_003119.2	Gene:	SPTBN1 / 6711	HGNCID:	11275	Length:	2364	Species:	Homo sapiens

Alignment Length:	2362	Identity:	1315/2362 - (55%)
Similarity:	1692/2362 - (71%)	Gaps:	84/2362 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RWDPSQGPGNEYIDEYEYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRIAD 73
            |||         :|  ::|..|||:||||||||||||:|||:||||||||||||||.||:|||.|
Human    24 RWD---------VD--DWDNENSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITD 77

  Fly    74 LYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGN 138
            ||.|:|||:.|||||||||||||||||||:||||||||||||||||:||||||||:|||||||||
Human    78 LYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGN 142

  Fly   139 ASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLA 203
            ..|.||||||||||||||||::|..||||.||||||||||||||||||.|||:.|||||||||:|
Human   143 HRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMA 207

  Fly   204 FNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVT 268
            |||:||||||||:.|:||.|:||.:||.|||::||..|||.||||.||:.|:|||||||||||||
Human   208 FNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVT 272

  Fly   269 YYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGV 333
            |||||||:|...|:|||||||:..|:|.:||:..||:..||||:|||.||..|..|:|.|||.||
Human   273 YYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGV 337

  Fly   334 QGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKA 398
            |.||..|:.|||:||||||.|||||||||||:||||||||||.|.|:|||:||||||||||||||
Human   338 QQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKA 402

  Fly   399 EHERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAI 463
            |||||||||.||||||||||||.||||||:||||||||||||||||||||||.|||||.||||||
Human   403 EHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAI 467

  Fly   464 ETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQ 528
            ||||.||||||||||||..|||:|.|||:|||..|||||:|||.||||||||||.|||::|.||:
Human   468 ETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQK 532

  Fly   529 NFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSD 593
            .|||||||:|.|:|:|.|:::.||||||:|||||||||:||||||.|..|||:.|..::|||.:|
Human   533 IFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATD 597

  Fly   594 DPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIV 658
            . |.||||||::|..||..:|..|.||.:||.|||:||||||:||:|:|:.|:||.||:|||:|:
Human   598 G-EGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKIL 661

  Fly   659 STDEVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKW 723
            |:|:.|.|||:|..:||||:|.|.|::......:...|.|.::|.|.|||:::|::|:..|..:|
Human   662 SSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQW 726

  Fly   724 DHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVAD 788
            .:|..|:..|::|||.|....|..|||||:|.||||.|:||||.|||.||.:.|||:|||||||:
Human   727 ANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKHKDVAE 791

  Fly   789 ELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYKLMS 853
            |:.||...:|.||:||.:|....||..:|..||..|:.||||:.||.:||||.|.|.|:|||:.|
Human   792 EIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFS 856

  Fly   854 EADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHP 918
            |||..|.||.||.:.|:.|...:.:||:|:::||||..:.|||..|||||||||:||||:|..||
Human   857 EADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHP 921

  Fly   919 NSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSLEM 983
            :..||..:|:.||..||..||..:.|.|.|.||..:|.:::||.||.|||.:|.:::..|..|..
Human   922 SEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGN 986

  Fly   984 DLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQML 1048
            ||.|||.|||:|:||:|||.||:||||.|::||..:|.|||::|:.|..|:|:|..:||::...|
Human   987 DLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTL 1051

  Fly  1049 KERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTE 1113
            |.|::.|.||..|.:||||||.||:||::|||.:||||.|.:|.||||||.||::|:.|||||.|
Human  1052 KNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEE 1116

  Fly  1114 DYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRDA 1178
            ||:.|.:.||.:| :|.|  |.||||||:||.||..||.|||:||||||.|||||...|.|.||.
Human  1117 DYQKMRDMGEMVT-QGQT--DAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDT 1178

  Fly  1179 RQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFDA 1243
            :|.|..|:.||:.|:..:.|..||.||..:|:.|.|:|||:||::|||.:::....||...:.::
Human  1179 KQAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINS 1243

  Fly  1244 DKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATSQDESYRSAKT 1308
            |:|.::.::|..|...||:.|.:...:||:...|.:||||.:||:.|:.||..|:||.||..|:.
Human  1244 DRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARN 1308

  Fly  1309 IHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKG 1373
            :||||.:||||.||:|:|||.|.:.||...:|..||||.:.|::.||..|.|.::.||..|:.|.
Human  1309 LHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKA 1373

  Fly  1374 AMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVEE 1438
            ..|||||:..|..|:|.|:|.::..||.||.|.|...||||||||::|||:::.||.|:.:::||
Human  1374 QRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEE 1438

  Fly  1439 IDKQTEYLQKTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWI 1503
            :..|.:.|.:  ..:..:.:..|:..|..:|.::..||.||:..|...||..||.||||||.||:
Human  1439 LQSQAQALSQ--EGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWV 1501

  Fly  1504 DEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLI-DEGHEDAKKFEAL 1567
            .|::|:|.|.|:|::|..|.:|.||||:|..||..|:|||:.|....:.:: |.....|:.....
Human  1502 GERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQR 1566

  Fly  1568 ISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLM 1632
            ::||.|.|..|.:..|.|.:.|.|:.:.|||:|||.|||:||||||||||.|::.|||.||.:::
Human  1567 LADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSML 1631

  Fly  1633 KKHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDAVAVKQSQLDKLYAGLKDLAGERRARLNE 1697
            |||:.|||:|||||.|:.||.:.:|....|.....:.::::||::|||||||||||.|||.:|:|
Human  1632 KKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDE 1696

  Fly  1698 ALQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVTLLSERFNEFARDTEAVGGERVAKVNGI 1762
            ..:||.|:||||||||||.:|||||||.|||||::|||:|.|||.||||||..:|.|||..||.:
Human  1697 RHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHL 1761

  Fly  1763 ADNLIQAGHSDSATIAEWKDNLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQH 1827
            ||.||.:||||:||||||||.|||:|.||||||:||||:||||.|||||:||.|::.|||.:|..
Human  1762 ADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHK 1826

  Fly  1828 GVSDELGRDAGSVSTLQRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLH 1892
            .:.:|||||..:|.||||.|..|..|:..|.:||:|:||::|:||.|||||||.:|..||.|||.
Human  1827 KLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLE 1891

  Fly  1893 AWDNLQAMCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSL 1957
            ||.:|...|::|:.:|.||||.||||:|||.||:||||::||:...|||||||.|||||||||.:
Human  1892 AWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGI 1956

  Fly  1958 KAEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQ 2022
            |||||.|.|:|..||.|||.||.|.||||.:||::|:.|:..|..::.:||:|||.|:|||||:|
Human  1957 KAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQ 2021

  Fly  2023 FARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSALERLTTFELKE 2087
            |:|||:||||||:.|||||.|.|:|.::||||.|||:|||||||||..:|||||||||||.||.|
Human  2022 FSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLE 2086

  Fly  2088 MKRRQE----------------LAEEAERQR----IKEEQEAKAASEAAEQAKREAERRDDVDV- 2131
            ::|:||                ::||||.|:    .|.||.::....|.:.:.|.||..|..::
Human  2087 VRRQQEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMV 2151

  Fly  2132 -GASHDDSAAKD--------------TAVEFERVVEIQTERGGTPGAGEGHEGYVTRKHEWDSTT 2181
             ||:...:::|:              ||:..:....:......||.|  ..||::.|||||::..
Human  2152 NGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPSA--QMEGFLNRKHEWEAHN 2214

  Fly  2182 KKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPELTFRGEPSYDLQNAAIEIASDYTKKKHVLRV 2246
            ||||:|||..||.......:.||||.|...|.  :.:..|....|:.|..|:|.||.|||||.::
Human  2215 KKASSRSWHNVYCVINNQEMGFYKDAKTAASG--IPYHSEVPVSLKEAVCEVALDYKKKKHVFKL 2277

  Fly  2247 KLANGALFLLQAHDDTEMSQWVTSLKA--QSDSTAV--------AASRSQTLPAT---------- 2291
            :|.:|..:|.||.||.||:.|:.::.:  .||...|        |:||:||||.:
Human  2278 RLNDGNEYLFQAKDDEEMNTWIQAISSAISSDKHEVSASTQSTPASSRAQTLPTSVVTITSESSP 2342

  Fly  2292 ------SQKDEPKRRSFFTLKK 2307
                  .:||:.||.|.|..||
Human  2343 GKREKDKEKDKEKRFSLFGKKK 2364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
beta-Spec	NP_001259660.1	CH	51..149	CDD:278723	84/97 (87%)
		CH	170..269	CDD:278723	76/98 (78%)
		Spectrin	298..408	CDD:278843	82/109 (75%)
		SPEC	422..521	CDD:197544	84/98 (86%)
		SPEC	525..740	CDD:238103	113/214 (53%)
		SPEC	639..846	CDD:238103	101/206 (49%)
		SPEC	848..1058	CDD:238103	103/209 (49%)
		SPEC	955..1169	CDD:238103	120/213 (56%)
		SPEC	1170..1380	CDD:238103	87/209 (42%)
		SPEC	1386..1484	CDD:197544	35/97 (36%)
		SPEC	1488..1699	CDD:238103	102/211 (48%)
		SPEC	1594..1806	CDD:238103	136/211 (64%)
		SPEC	1807..2015	CDD:238103	118/207 (57%)
		Spectrin	2018..>2078	CDD:278843	43/59 (73%)
		PH	2167..2275	CDD:278594	44/109 (40%)
		PH_beta_spectrin	2167..2274	CDD:269975	44/108 (41%)
SPTBN1	NP_003119.2	Actin-binding	2..275		202/261 (77%)
		CH_SPTBN1_rpt1	3..156	CDD:409165	110/142 (77%)
		SAC6	48..>530	CDD:227401	383/481 (80%)
		CH_SPTB_like_rpt2	173..277	CDD:409097	81/103 (79%)
		Spectrin 1. /evidence=ECO:0000255	303..411		80/107 (75%)
		Spectrin 2. /evidence=ECO:0000255	423..525		86/101 (85%)
		SPEC	530..743	CDD:238103	113/213 (53%)
		Spectrin 3. /evidence=ECO:0000255	530..636		65/106 (61%)
		Spectrin 4. /evidence=ECO:0000255	639..742		43/102 (42%)
		SPEC	642..849	CDD:238103	101/206 (49%)
		Spectrin 5. /evidence=ECO:0000255	745..847		57/101 (56%)
		Spectrin 6. /evidence=ECO:0000255	850..952		51/101 (50%)
		SPEC	851..1061	CDD:238103	103/209 (49%)
		Spectrin 7. /evidence=ECO:0000255	957..1060		49/102 (48%)
		SPEC	958..1169	CDD:238103	120/213 (56%)
		Spectrin 8. /evidence=ECO:0000255	1063..1166		66/105 (63%)
		Spectrin 9. /evidence=ECO:0000255	1170..1258		32/87 (37%)
		SPEC	1171..1380	CDD:238103	87/208 (42%)
		Spectrin 10. /evidence=ECO:0000255	1276..1376		47/99 (47%)
		SPEC	1381..1592	CDD:238103	81/212 (38%)
		Spectrin 11. /evidence=ECO:0000255	1381..1482		36/102 (35%)
		Spectrin 12. /evidence=ECO:0000255	1486..1590		42/103 (41%)
		Interaction with ANK2. /evidence=ECO:0000269\|PubMed:15262991	1563..2093		321/529 (61%)
		SPEC	1593..1805	CDD:238103	136/211 (64%)
		SPEC	1806..2027	CDD:238103	128/220 (58%)
		Spectrin	2017..>2075	CDD:395348	41/57 (72%)
		Spectrin 17. /evidence=ECO:0000255	2018..2097		54/78 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2089..2196		21/106 (20%)
		Mediates interaction with CAMSAP1. /evidence=ECO:0000269\|PubMed:24117850	2149..2177		3/27 (11%)
		PH_beta_spectrin	2200..2305	CDD:269975	44/106 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2309..2364		15/54 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152402
Domainoid	1	1.000	191	1.000	Domainoid score	I3245
eggNOG	1	0.900	-	-		E2759_KOG0517
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2354
Inparanoid	1	1.050	2488	1.000	Inparanoid score	I31
Isobase	1	0.950	-	0	Normalized mean entropy	S2395
OMA	1	1.010	-	-		QHG52262
OrthoDB	1	1.010	-	-		D15759at33208
OrthoFinder	1	1.000	-	-		FOG0000586
OrthoInspector	1	1.000	-	-		otm41171
orthoMCL	1	0.900	-	-		OOG6_100348
Panther	1	1.100	-	-	LDO	PTHR11915
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3302
SonicParanoid	1	1.000	-	-		X1255
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750