DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and SPTB

DIOPT Version :10

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:NP_001020029.1 Gene:SPTB / 6710 HGNCID:11274 Length:2328 Species:Homo sapiens


Alignment Length:2340 Identity:1118/2340 - (47%)
Similarity:1542/2340 - (65%) Gaps:74/2340 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 RWDPSQGPGNEYIDEYEYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRIAD 73
            |||   .|.:      |.|..|||:||||||||||||:|||.||||||||||||||.||:|||.|
Human    22 RWD---APDD------ELDNDNSSARLFERSRIKALADEREVVQKKTFTKWVNSHLARVSCRITD 77

  Fly    74 LYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGN 138
            ||.|:|||:.|||||||||||.||||||||||||||||||||||||:||||||||:|||||||||
Human    78 LYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGN 142

  Fly   139 ASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLA 203
            ..|.||||||||||||||||.::..:.:||:|||||||||||||||||.:|||.|||:||:||||
Human   143 HRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLA 207

  Fly   204 FNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVT 268
            |||:||||||||:.|:||..:||.|||.:||:|||.:||:..|||.||||.|:|||||||||||.
Human   208 FNALIHKHRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVA 272

  Fly   269 YYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGV 333
            :||||||:|...|:|||:|||:..|:|.:||:..|....||||.|||.||..|..|:|.|||.||
Human   273 FYHYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGV 337

  Fly   334 QGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKA 398
            |.||..||.|||:||||||.|||||||||||:||:|||||||.|||.:||::||||:|||.||:|
Human   338 QQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEA 402

  Fly   399 EHERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAI 463
            |:.||||||.||||||||||||.||||||:|||||||||||||:|||||:||||||||.||||||
Human   403 EYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAI 467

  Fly   464 ETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQ 528
            |||..||||||:|:..:..|||.|.|||.|||..||||::|||:||.|||::||.|||.:|.||:
Human   468 ETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQK 532

  Fly   529 NFQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSD 593
            .||:||:.:|.|:|||..|::.::||||:.||||||||.|:||||.|.|::||.:...:.||  .
Human   533 LFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF--T 595

  Fly   594 DPESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIV 658
            :.:.|:||||::|..|:..||..:.||..:|..|:::||:|::||:|:|:..:.|:||||||||.
Human   596 EGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660

  Fly   659 STDEVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKW 723
            |:.:.|.|||:|.::..||||.|.|:...|..|:.:.:....::....||..:|:.|:||:..:|
Human   661 SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQW 725

  Fly   724 DHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVAD 788
            |.|.||..:.::.|::|..:||...||||:..|:.|..|::|.||||:||...::|.|||||..:
Human   726 DQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLE 790

  Fly   789 ELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYKLMS 853
            ||:....|::.|.:||:.......:..:|..||:|:...|:::...|.||:|||.:||.||.:..
Human   791 ELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFG 855

  Fly   854 EADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEHP 918
            |.|..|.|:.||.|.|..|.....:||:|:::|||:..|:||....:::..||..|..|:...||
Human   856 ETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920

  Fly   919 NSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSLEM 983
            .|.|:.:.|:|||..|...:.....:.:.:.||..|..:.::|.||..||.||.:::..|..|..
Human   921 RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGR 985

  Fly   984 DLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQML 1048
            ||.|::.:||:|||::||:|||||::.:||||:..:.|.|||:.:.|.:|...:|.:|:.|.|.|
Human   986 DLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSL 1050

  Fly  1049 KERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTE 1113
            :.::..|.|...|..||:|||.||.||:.||..|||||.|.||||||:||.||..|::|||.:.:
Human  1051 QGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQD 1115

  Fly  1114 DYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRDA 1178
            .|:.:.|.||::. :|.|  ||:|:.|.:||..|..||..|.:|||:|...|:|.|..|.|.:||
Human  1116 SYQRVKESGEKVI-QGQT--DPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDA 1177

  Fly  1179 RQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFDA 1243
            :|.|.:||.||:.|:..:.|.:||.||..:::.|.||.:||.|.||:.:.:...:.||.:.:..:
Human  1178 KQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYS 1242

  Fly  1244 DKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATSQDESYRSAKT 1308
            |||.::.:.|..|...|.::|.:....|::.::|..|||:.:||..|:.:|..||||.||..|:.
Human  1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARN 1307

  Fly  1309 IHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKG 1373
            :|:||.:||||.||:|:::..|...:...::|..|||:|..::..||:.|.:.:|:|:..||||.
Human  1308 LHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKT 1372

  Fly  1374 AMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVEE 1438
            ..|..|....|..||..|::.:|:.:|.|:.|.|...||||||.::.|.:.::.|:.|:..::.|
Human  1373 QHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGE 1437

  Fly  1439 IDKQTEYLQKTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWI 1503
            :..|...:.:...:..:        ::.:||..:..||..|:|.||..:...|..||:|||.||:
Human  1438 LFAQVPSMGEEGGDADL--------SIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWV 1494

  Fly  1504 DEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAKKFEALI 1568
            :|:||:|.|.|||.:|..|.:..||||:|..||..|.||:..:...|::|::....|.:..|..:
Human  1495 EERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERL 1559

  Fly  1569 SDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMK 1633
            ..|...|..|::|...|.:.|.::.:.|||:.||.|||:|:.|||||::.::..|||..|..::|
Human  1560 GHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLK 1624

  Fly  1634 KHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDAVAVKQSQLDKLYAGLKDLAGERRARLNEA 1698
            :|...:::||||...|:||...|:.........|:.:...|.|:||.||||||:|.||:.:|...
Human  1625 RHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENM 1689

  Fly  1699 LQLFMLSREVDDLEQWITDREVVAGSQELGQDFDHVTLLSERFNEFARDTEAVGGERVAKVNGIA 1763
            ..||.|.||.|||||||:::|:||.|.|:||||||||||.::|.:|||:|.|:|.|||..||...
Human  1690 YHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFI 1754

  Fly  1764 DNLIQAGHSDSATIAEWKDNLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHG 1828
            :.||.||||::||||||||.|||.|.||||||:||.|:||||.:||::|:...::||.|.||...
Human  1755 ERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRE 1819

  Fly  1829 VSDELGRDAGSVSTLQRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHA 1893
            :.:::|.||.:..:..|.|..|.::|..|..||||.|:.:.:||.||||:||:.|.|:||||..|
Human  1820 LPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAA 1884

  Fly  1894 WDNLQAMCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLK 1958
            |..|...|..|:.:|.||.|.||||:|.|.|:.|||.::||:.|.|:|||||.|||||..||.:.
Human  1885 WQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGIN 1949

  Fly  1959 AEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQF 2023
            |||:||..||.||:.||:.||.|.|.||.:|:::|..:.:.|..:..:||.|||.|:::|||.||
Human  1950 AEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQF 2014

  Fly  2024 ARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSALERLTTFELKEM 2088
            :|||:|||||||||||||.|.:.|||:|.||.|||:|||||||.|:..|||:|||:.||.|||| 
Human  2015 SRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKE- 2078

  Fly  2089 KRRQELAEEAERQRIKEEQEAKAASEAAEQAKREAERRDDVDVGAS-------------HDDSA- 2139
               :::||....:...:|:|.:.|.||........||....:...:             |.|.. 
Human  2079 ---RQIAERPAEETGPQEEEGETAGEAPVSHHAATERTSPGEEEGTWPQNLQQPPPPGQHKDGQK 2140

  Fly  2140 ----AKDTAVEFERVVEIQTERGGTPG---AGEGH------EGYVTRKHEWDSTTKKASNRSWDK 2191
                .:.|.....:|::.....|..|.   |...|      |||:.|||:.:...||||||||:.
Human  2141 STGDERPTTEPLFKVLDTPLSEGDEPATLPAPRDHGQSVQMEGYLGRKHDLEGPNKKASNRSWNN 2205

  Fly  2192 VYMAAKAGRISFYKDQKGYKSNPELTFRGEPSYDLQNAAIEIASDYTKKKHVLRVKLANGALFLL 2256
            :|...:...::||||.|.....  :.:.||....|::|..|||::|.|||||.:::|:||:.:|.
Human  2206 LYCVLRNSELTFYKDAKNLALG--MPYHGEEPLALRHAICEIAANYKKKKHVFKLRLSNGSEWLF 2268

  Fly  2257 QAHDDTEMSQWVTSLKAQSDSTAVAASRS-----QTLPATS---------QKDEPKRRSFFTLKK 2307
            ...|:.||..|:     |..|||:..|:|     |:||..|         :||:.||.|||..||
Human  2269 HGKDEEEMLSWL-----QGVSTAINESQSIRVKAQSLPLPSLSGPDASLGKKDKEKRFSFFPKKK 2328

  Fly  2308  2307
            Human  2329  2328

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH_SPTB-like_rpt1 36..152 CDD:409095 100/115 (87%)
CH_SPTB_like_rpt2 169..273 CDD:409097 76/103 (74%)
Spectrin 298..408 CDD:395348 75/109 (69%)
SPEC 422..521 CDD:197544 73/98 (74%)
SPEC 525..740 CDD:238103 90/214 (42%)
SPEC 639..846 CDD:238103 77/206 (37%)
SPEC 848..1058 CDD:238103 76/209 (36%)
SPEC 955..1169 CDD:238103 95/213 (45%)
SPEC 1170..1380 CDD:238103 75/209 (36%)
SPEC 1386..1484 CDD:197544 25/97 (26%)
SPEC 1488..1699 CDD:238103 81/210 (39%)
SPEC 1594..1806 CDD:238103 112/211 (53%)
SPEC 1807..2015 CDD:238103 95/207 (46%)
Spectrin 2018..>2078 CDD:395348 43/59 (73%)
PH_beta_spectrin 2167..2274 CDD:269975 42/112 (38%)
SPTBNP_001020029.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 4/16 (25%)
Actin-binding 2..275 195/261 (75%)
CH_SPTBN2_rpt1 25..156 CDD:409166 108/136 (79%)
CH_SPTB_rpt2 170..281 CDD:409168 82/110 (75%)
Spectrin 302..412 CDD:395348 75/109 (69%)
Spectrin 1. /evidence=ECO:0000255 303..411 73/107 (68%)
Spectrin 422..525 CDD:395348 76/102 (75%)
Spectrin 2. /evidence=ECO:0000255 423..525 75/101 (74%)
Spectrin 3. /evidence=ECO:0000255 529..635 49/107 (46%)
SPEC 530..742 CDD:238103 90/213 (42%)
Spectrin 4. /evidence=ECO:0000255 638..741 39/102 (38%)
SPEC 641..848 CDD:238103 77/206 (37%)
Spectrin 5. /evidence=ECO:0000255 744..846 39/101 (39%)
SPEC 745..954 CDD:238103 75/208 (36%)
Spectrin 6. /evidence=ECO:0000255 851..950 32/98 (33%)
SPEC 955..1168 CDD:238103 96/215 (45%)
Spectrin 7. /evidence=ECO:0000255 956..1058 40/101 (40%)
Spectrin 8. /evidence=ECO:0000255 1062..1165 52/105 (50%)
SPEC 1170..1379 CDD:238103 75/208 (36%)
Spectrin 9. /evidence=ECO:0000255 1170..1257 31/86 (36%)
Spectrin 10. /evidence=ECO:0000255 1275..1375 40/99 (40%)
SPEC 1385..1475 CDD:197544 25/97 (26%)
Spectrin 11. /evidence=ECO:0000255 1389..1465 19/83 (23%)
Spectrin 12. /evidence=ECO:0000255 1481..1582 38/100 (38%)
SPEC 1485..1690 CDD:238103 80/204 (39%)
Spectrin 13. /evidence=ECO:0000255 1585..1688 43/102 (42%)
Spectrin 14. /evidence=ECO:0000255 1690..1793 66/102 (65%)
SPEC 1691..1901 CDD:238103 111/209 (53%)
Spectrin 15. /evidence=ECO:0000255 1797..1899 40/101 (40%)
SPEC 1798..2005 CDD:238103 95/206 (46%)
Spectrin 16. /evidence=ECO:0000255 1906..2006 51/99 (52%)
Spectrin 17. /evidence=ECO:0000255 2013..2075 44/61 (72%)
Spectrin 2013..>2070 CDD:395348 41/56 (73%)
PH_beta_spectrin 2181..2286 CDD:269975 43/111 (39%)

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