DRSC/TRiP Functional Genomics Resources

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Protein Alignment beta-Spec and SPTAN1

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:NP_001362247.1 Gene:SPTAN1 / 6709 HGNCID:11273 Length:2510 Species:Homo sapiens


Alignment Length:1886 Identity:534/1886 - (28%)
Similarity:876/1886 - (46%) Gaps:341/1886 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   594 DPESYKPCD-PEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQI 657
            ||...|..: .|.|..|.||:.|.|.....|:..||.:||:|.:...|..|..:.|.||:||.||
Human    14 DPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQI 78

  Fly   658 VSTDEVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNK 722
            .| ||...|.|.:...|.||:|.|:|:.::...:..:.:.|:.:|:||||.::.|:.||.|:..:
Human    79 AS-DENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQ 142

  Fly   723 WDHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVA 787
            |:.||:..:.:..:|..|.:..|...:.:||.:|:.|...||:||::                  
Human   143 WELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEEL------------------ 189

  Fly   788 DELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYKLM 852
                                                                             
Human   190 ----------------------------------------------------------------- 189

  Fly   853 SEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNANASRVAVVNQLARQLLHVEH 917
                                  |:|:|.||:::.:||.|..:|.|:..||..|||.|.:|:..:|
Human   190 ----------------------GQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQH 232

  Fly   918 PNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECRETISWIEDKKRILTETDSLE 982
            |..:.|..:|:.:|..|..|:..|..:...|..|..||.|..:..||||||::|::::. :|...
Human   233 PEEELIKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMA-SDDFG 296

  Fly   983 MDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQM 1047
            .||..|..|.|:..|::|||||::.|:.:|..||:.::..||..|..|:.:..::...|||:..:
Human   297 RDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTL 361

  Fly  1048 LKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYT 1112
            ..||.::|.::..|.|||.|.....:|:|:.:..:.:::..:.:..||.||::||..:.|||.:.
Human   362 AAERHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHE 426

  Fly  1113 EDYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRD 1177
            :.:|:..|.|:.|.:.|..:.|.    :||:|..|.:....|.::||.|:....|.:|.|||.||
Human   427 DSFKSADESGQALLAAGHYASDE----VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRD 487

  Fly  1178 ARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFD 1242
            ..|.:..:|:||.||..:|...:|:..|..||:||.|..::.|.::||..|.:.|..|::.:|:.
Human   488 TEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYA 552

  Fly  1243 ADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATSQDESYRSAK 1307
            .:.:..|.:.:..||:...:||:.:..:|.:...|.:|.:|.:||..||.||..|:.||:|:...
Human   553 MEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPS 617

  Fly  1308 TIHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEK 1372
            .:..|..:|||||||::||:.|:...||:.|:|.......||.:..::.|:...:..|...|:.|
Human   618 NLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELK 682

  Fly  1373 GAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVE 1437
            |..|.:||::....:..:||:.::.::|..:.|.|...|||:|..|.:|..:::..:|....:::
Human   683 GIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRID 747

  Fly  1438 EIDKQTEYLQKTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLW 1502
            .|..|....| .......|.|..|:.|::.|:|.:|.|::.|::.|.......|..||||||:.|
Human   748 GITIQARQFQ-DAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETW 811

  Fly  1503 IDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAKKFEAL 1567
            |.||.|:|.|.:.|..|..|..|.||:|:|..||..|||||.|:...|..:::|||..|:..:|.
Human   812 IREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAK 876

  Fly  1568 ISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLM 1632
            :.:|.|||:.||.....||:.|.:|.:.||||.||.||||||.|:|..:...|.||||.||:.|:
Human   877 LHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALL 941

  Fly  1633 KKHENLEQSVEDYANTIRQLGEVA----RQFSGDD-----------------------ISSGD-- 1668
            ||||.|...:..|.::|:.|.|.|    :|.:..|                       :..||  
Human   942 KKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTMKKGDIL 1006

  Fly  1669 ----------------------------------------------AVAVKQSQLD--------- 1678
                                                          ::|::|.|:|         
Human  1007 TLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEA 1071

  Fly  1679 -----------KLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQDFD 1732
                       :||..|.:|..:|:..|.::.:.|||.||.::|:|||.::|....|:|:|.|.:
Human  1072 GSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1136

  Fly  1733 HVTLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAG---------------------HSDSAT 1776
            .|.:|.::|::|.:|.:| ...|:..:|.:|::|...|                     .:||.|
Human  1137 QVEVLQKKFDDFQKDLKA-NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1200

  Fly  1777 IAEWKD---------------NLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQ 1826
            .:.||.               .|||.|:.|.:|.|.|:|:|.::.|:.:|..|..:....|.||.
Human  1201 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKN 1265

  Fly  1827 HGV-SDELGRDAGSVSTLQRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKAKEITNREQEV 1890
            ..: :|..|.|..||..|||||..|.:||..|..:|..:.|.:.:|..::. :.|:::..:..|:
Human  1266 QALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHP-ESAEDLQEKCTEL 1329

  Fly  1891 LHAWDNLQAMCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQ 1955
            ..||.:|....|.||.||.|:.||.||.:..|.||.|:..:...:::.|..:||:|.|.|:..||
Human  1330 NQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQ 1394

  Fly  1956 SLKAEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILEV 2020
            ..:.|||.|...|.|....|::||...||||.:||.:|..|...|..|.:.|.:|...|...||:
Human  1395 EHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLEL 1459

  Fly  2021 YQFARDAAVAEAWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSALERLTTFEL 2085
            ..|.||...||.|:.|:|.:|.:.:.|.::|.||.||||||.|:|:...|||:.:||:......:
Human  1460 QLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLI 1524

  Fly  2086 KE--------MKRRQELAEEAERQRIK--EEQEAKAASEAAEQAKREAERRDDVDVGASH----- 2135
            ..        ..||.|:.:...|.:.:  |::.....|:..:|..|:.   |:::...|.     
Human  1525 AAGHYAKGDISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDV---DEIEAWISEKLQTA 1586

  Fly  2136 -DDSAAKDTAVE-------------FERVVEIQTER-------GGT---PGAGEGHEGYVTRK-- 2174
             |:|....|.::             ||..:....:|       |.:   .||..|.|..|..:  
Human  1587 SDESYKDPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLA 1651

  Fly  2175 ---HEWDSTTKKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPELTFR-GEPSYDLQNAAIE--I 2233
               .:|....:|::.:|                  ||..::|.:..|. |...:|...:.:|  :
Human  1652 ALADQWQFLVQKSAEKS------------------QKLKEANKQQNFNTGIKDFDFWLSEVEALL 1698

  Fly  2234 AS-DYTK---------KKH-VLRVKLANGALFLLQAHDDTEMSQWVTSLKAQSDS--TAVAASRS 2285
            || ||.|         ||| :|...::        ||:|.     :..|.:|:||  |:.|...|
Human  1699 ASEDYGKDLASVNNLLKKHQLLEADIS--------AHEDR-----LKDLNSQADSLMTSSAFDTS 1750

  Fly  2286 Q 2286
            |
Human  1751 Q 1751

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723
CH 170..269 CDD:278723
Spectrin 298..408 CDD:278843
SPEC 422..521 CDD:197544
SPEC 525..740 CDD:238103 50/146 (34%)
SPEC 639..846 CDD:238103 44/206 (21%)
SPEC 848..1058 CDD:238103 63/209 (30%)
SPEC 955..1169 CDD:238103 66/213 (31%)
SPEC 1170..1380 CDD:238103 69/209 (33%)
SPEC 1386..1484 CDD:197544 24/97 (25%)
SPEC 1488..1699 CDD:238103 92/305 (30%)
SPEC 1594..1806 CDD:238103 86/342 (25%)
SPEC 1807..2015 CDD:238103 71/208 (34%)
Spectrin 2018..>2078 CDD:278843 27/59 (46%)
PH 2167..2275 CDD:278594 25/126 (20%)
PH_beta_spectrin 2167..2274 CDD:269975 25/125 (20%)
SPTAN1NP_001362247.1 Spectrin 56..158 CDD:334073 33/102 (32%)
SPEC 162..373 CDD:238103 72/316 (23%)
SPEC 374..584 CDD:238103 64/213 (30%)
SPEC 480..690 CDD:238103 69/209 (33%)
SPEC 691..902 CDD:238103 70/211 (33%)
Spectrin 902..>983 CDD:334073 34/80 (43%)
SH3_Alpha_Spectrin 983..1035 CDD:212742 2/51 (4%)
SPEC 1104..1351 CDD:238103 74/248 (30%)
SPEC 1246..1457 CDD:238103 72/211 (34%)
SPEC 1458..1675 CDD:238103 54/237 (23%)
Spectrin 1675..1777 CDD:334073 25/90 (28%)
SPEC 1782..1991 CDD:238103
SPEC 1888..2099 CDD:238103
SPEC 1995..2213 CDD:238103
SPEC 2113..2350 CDD:238103
EFh 2365..2433 CDD:238008
EFhand_Ca_insen 2440..2508 CDD:312305
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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