DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and SPTA1

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:NP_003117.2 Gene:SPTA1 / 6708 HGNCID:11272 Length:2419 Species:Homo sapiens


Alignment Length:1736 Identity:442/1736 - (25%)
Similarity:787/1736 - (45%) Gaps:203/1736 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   709 ADRIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLF-ADADDVDNWMLDTLRIVSSEDVGRD 772
            |:.|::|.:|:|.::....:....|.|:||::. :.|:| .||||:..|:::.:.|::.:.. .|
Human    21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSY-HLQVFKRDADDLGKWIMEKVNILTDKSY-ED 83

  Fly   773 EANVQSLLKKHKDVADELKNYAEVIDALHKQAESL-----KLNEAEKANVDKRLEAIDNRYKELT 832
            ..|:|...:||:.:..|::..:.::..|.|..|..     ..:|..||::    |.:.:.:..|.
Human    84 PTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHI----EELRHLWDLLL 144

  Fly   833 ELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIMKHRFEGFDKEMNA 897
            ||...:..:||.||...:.:.|...:.:||.:|..:..::..|:|.|..|::..:||.|..|:.|
Human   145 ELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKFEDFQVELVA 209

  Fly   898 NASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHGVQTFYIECR 962
            ...||..|||.|.:.....||:...|..:||.:|..|..||..|..:...|.:|..:|.|..:..
Human   210 KEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVT 274

  Fly   963 ETISWIEDKKRILTETDSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEA 1027
            |.|.||::|:.:||..| ...||.....|.....|::|:||.:..|:..|..:|..:...||.:|
Human   275 EAIQWIKEKEPVLTSED-YGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDA 338

  Fly  1028 KIIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLP 1092
            ..|:|....:...||.:..:...|..||:.....|||..|.|....|:.:....:.:::.||.:.
Human   339 PQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVA 403

  Fly  1093 EAEKLLNQHQSIREEIDNYTEDYKNMMEYGERLTSEGSTSDDPQYMFLRERLNALKDGWEELHQM 1157
            ..|.||::||..:.|||:|.:.:::..|.|:.|.:....:.|.    :||::..|.:.|..|.::
Human   404 GGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDE----VREKMEILDNNWTALLEL 464

  Fly  1158 WENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPVNLEQAENQLKRHEAFLTTMEAND 1222
            |:.|.....|.||..||.||:.|.:..:|:||.||..:|...:|..||..|::||.|.....|.:
Human   465 WDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQE 529

  Fly  1223 DKINTLLQVADTLVEKDHFDADKIGKRAENITGRRDDNRQRALDQHEKLKNQVKLHEFLQDLEEL 1287
            :||.|:.:.|..|:..||:|::.|....:.:..|||..|::|..:...||..:.|.:..:|.::|
Human   530 EKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDL 594

  Fly  1288 AEWVQEKYATSQDESYRSAKTIHSKWTRHQAFEAEIAANKERLFEAEKSAQELSKEKPEFKDVIE 1352
            ..|:.:|...:.||.|:..:.:.|:..:.|.||.|:|.||.:|...:|:.||:.:......|.:.
Human   595 KNWINKKKKLADDEDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVT 659

  Fly  1353 PKLKELAKQFDDLEVHTKEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVSGDTANDLTSVNI 1417
            .:|.|:|..:::|...||:||..|.:||:::..:...:|:..::.|:|.|:.|.|....|..|..
Human   660 TRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQN 724

  Fly  1418 LMQKQQVIQTQMAVKARQVEEIDKQTEYLQKT-VPEEKIEPIVVKKTAVLERFEKIKAPLLERQK 1481
            .::|..::::.:|.:..||:.:.....|.::. .|:.|  .|..::.:::.|||.:|.||..|:|
Human   725 RLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSK--DIRARQESLVCRFEALKEPLATRKK 787

  Fly  1482 ALEKKKEAFQFCRDVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAI 1546
            .|.........|||.|||:.||.|..|.|.|...|..|.....|..:::.:...|.:|||||..|
Human   788 KLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEI 852

  Fly  1547 CNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAESWMSE 1611
            ...|.|:::|||..|:...:.:..|.|..:.|:.....|:..|..:.:.|||..|..|||:|:.|
Human   853 TERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWIRE 917

  Fly  1612 QELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQL-------------------GE--- 1654
            :|..:...:.|.||.:|..|:||||.....:..:.::::.|                   ||   
Human   918 KEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQRV 982

  Fly  1655 ------VARQFSGDDISSGDAVAV----------------------------------------- 1672
                  .||......:..||.:.:                                         
Human   983 MALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRR 1047

  Fly  1673 --------KQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQ 1729
                    :|.|::..|..|.|.|.|||.||.:....|:|:.|..|:.:||.:::    ::..|.
Human  1048 EEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKK----AENTGV 1108

  Fly  1730 DFDHVTLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAG--HSDSATIAEWKDNLNESWQDLL 1792
            :.|.|..|.::|:||.:|.. ....|:..:|.:||:|:..|  ..:.|.|   :..||..|..|.
Human  1109 ELDDVWELQKKFDEFQKDLN-TNEPRLRDINKVADDLLFEGLLTPEGAQI---RQELNSRWGSLQ 1169

  Fly  1793 ELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGVS-DELGRDAGSVSTLQRKHYNFLQDLIT 1856
            .|.:.:.|:|.::..:..|..:..|...:|.:|...:| .:.|.|..||..|||:|..|.:||:.
Human  1170 RLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVP 1234

  Fly  1857 LYSQVQQIQEESAKLQDAYAGDKAKEITNREQEVLHAWDNLQAMCDARKQKLADTGDLFRFFNMV 1921
            |..:|..:.|.:.:|.:::. |..:::..::.|:..||::||.....||:.|.:....:.|.:..
Human  1235 LGDKVTILGETAERLSESHP-DATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKA 1298

  Fly  1922 RILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYAS 1986
            |.|..|:..:...:::.|...|::|:|:|:..||..:|:::.....|.|......||:...|:||
Human  1299 RDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHAS 1363

  Fly  1987 ADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAVAEAWLIAQEPYLLSSELGHTID 2051
            .:|:.:|..:...|:.|.:.||:|.:.|...||:..|..:....|:|::|:|..|.|.:.. ::|
Human  1364 PEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKS-SLD 1427

  Fly  2052 EVENLIKKHEAFEKSAAAQEERFSALERLT-TFELKEMKRRQELAEEAERQRIKEEQEAKAASEA 2115
            .:|.|:||.:..:|:..|||.:.:.||... :....|...::|:|  ...||:.:..:|..|...
Human  1428 SLEALMKKRDDLDKAITAQEGKITDLEHFAESLIADEHYAKEEIA--TRLQRVLDRWKALKAQLI 1490

  Fly  2116 AEQAK-----------REAERRDD--VDVGASHDDSAAKDTAVEFERVVEIQTERGGTPGAGEGH 2167
            .|:.|           |:.|..::  .::..:..|.:.||......:.::.||......|..|..
Human  1491 DERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQV 1555

  Fly  2168 EGYVT------------------------RKHEWDSTTKKASNRS----------------WDKV 2192
            .|.:.                        .|..||...::.:::.                .|..
Human  1556 HGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFE 1620

  Fly  2193 YMAAKAGRISFYKDQ------------KGYKSNPELTFRGEPSYDLQNAAIEIASDYT------- 2238
            :..::|..:...|||            |......|:..|.:...||...|.::.|..|       
Human  1621 FWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIV 1685

  Fly  2239 KKK----------------HVLRVKLANGALFLLQAHDDTEMSQWV 2268
            |||                |..::|.|.......|..||.|  .|:
Human  1686 KKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEE--SWI 1729

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723
CH 170..269 CDD:278723
Spectrin 298..408 CDD:278843
SPEC 422..521 CDD:197544
SPEC 525..740 CDD:238103 9/30 (30%)
SPEC 639..846 CDD:238103 35/142 (25%)
SPEC 848..1058 CDD:238103 61/209 (29%)
SPEC 955..1169 CDD:238103 59/213 (28%)
SPEC 1170..1380 CDD:238103 66/209 (32%)
SPEC 1386..1484 CDD:197544 24/98 (24%)
SPEC 1488..1699 CDD:238103 70/287 (24%)
SPEC 1594..1806 CDD:238103 66/290 (23%)
SPEC 1807..2015 CDD:238103 55/208 (26%)
Spectrin 2018..>2078 CDD:278843 18/59 (31%)
PH 2167..2275 CDD:278594 28/177 (16%)
PH_beta_spectrin 2167..2274 CDD:269975 28/177 (16%)
SPTA1NP_003117.2 Spectrin 1. /evidence=ECO:0000255 53..155 24/107 (22%)
Spectrin 53..138 CDD:278843 21/90 (23%)
SPEC 159..370 CDD:238103 61/211 (29%)
Spectrin 2. /evidence=ECO:0000255 159..261 29/101 (29%)
Spectrin 3. /evidence=ECO:0000255 265..367 29/102 (28%)
SPEC 266..476 CDD:238103 59/214 (28%)
Spectrin 4. /evidence=ECO:0000255 371..474 28/106 (26%)
SPEC 477..687 CDD:238103 66/209 (32%)
Spectrin 5. /evidence=ECO:0000255 477..580 35/102 (34%)
Spectrin 6. /evidence=ECO:0000255 583..685 30/101 (30%)
SPEC 688..897 CDD:238103 58/210 (28%)
Spectrin 7. /evidence=ECO:0000255 688..790 24/103 (23%)
Spectrin 8. /evidence=ECO:0000255 794..896 32/101 (32%)
Spectrin 9. /evidence=ECO:0000255 900..969 20/68 (29%)
SPEC 902..>958 CDD:197544 19/55 (35%)
SH3 982..1033 CDD:302595 4/50 (8%)
Spectrin 1082..1179 CDD:278843 28/104 (27%)
Spectrin 10. /evidence=ECO:0000255 1087..1179 27/99 (27%)
Spectrin 11. /evidence=ECO:0000255 1185..1287 29/102 (28%)
SPEC 1186..1395 CDD:238103 56/209 (27%)
Spectrin 12. /evidence=ECO:0000255 1290..1392 26/101 (26%)
SPEC 1396..1606 CDD:238103 41/212 (19%)
Spectrin 13. /evidence=ECO:0000255 1396..1497 28/103 (27%)
Spectrin 14. /evidence=ECO:0000255 1501..1605 13/103 (13%)
SPEC 1608..1819 CDD:238103 24/124 (19%)
Spectrin 15. /evidence=ECO:0000255 1608..1711 17/102 (17%)
Spectrin 16. /evidence=ECO:0000255 1714..1817 5/18 (28%)
SPEC 1715..1926 CDD:238103 5/17 (29%)
Spectrin 17. /evidence=ECO:0000255 1820..1926
Spectrin 18. /evidence=ECO:0000255 1929..2033
SPEC 1930..2148 CDD:238103
Spectrin 19. /evidence=ECO:0000255 2044..2146
SPEC 2047..2260 CDD:238103
Spectrin 20. /evidence=ECO:0000255 2158..2258
EFh 2275..2343 CDD:298682
EF-hand_7 2278..2343 CDD:290234
EFhand_Ca_insen 2350..2418 CDD:285885
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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