DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and DST

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_016866694.1 Gene:DST / 667 HGNCID:1090 Length:7827 Species:Homo sapiens


Alignment Length:2654 Identity:589/2654 - (22%)
Similarity:1017/2654 - (38%) Gaps:698/2654 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 ERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRIADLYVDMRDGKHLIKLLEVLSGERLPKP-- 99
            ||:.:: :|:||:.|||||||||:|.||.:|...:.|||.|:|||.:||.|||||||:.||:.  
Human   210 ERAVLR-IADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRERD 273

  Fly   100 ------------------------------TKGKMRIHCLENVDKALQFLREQRVHLENIGSHDI 134
                                          .||:||.|.|:||..||.:|:.::|.|.||.:.||
Human   274 FLKTLRLVSATEACEYEQHEDVEDEDKGPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDI 338

  Fly   135 VDGNASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWR 199
            .|||..|.|||||||||.|||.||.:  ....|..|||:.||||.|..|.||..:...||||.||
Human   339 TDGNPKLTLGLIWTIILHFQISDIHV--TGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWR 401

  Fly   200 DGLAFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIIT 264
            ||..|||||||:||||:....::..:.:.||.:||.||| |:|:.:|||.|||.|..|||||:||
Human   402 DGKLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAE-KIGVIRLLDPEDVDVSSPDEKSVIT 465

  Fly   265 YVVTYYHYFSKLKQETVQGKRIGKVVGIAMENDKMVH--DYENFTSDLLKWIETTIQSLGEREFE 327
            ||.:.|..|.|:.:   .|:.||       .||..|.  :|:|..:.|::||...:.::.||.|.
Human   466 YVSSLYDAFPKVPE---GGEGIG-------ANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFP 520

  Fly   328 NSLAGVQGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKM---RANNQKPYTPKEGKMISDIN 389
            |:...::....|:..::..|.|||..||..::.|...|:..:   |....:.|.|      :||.
Human   521 NNPVELKALYNQYLQFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHP------NDIE 579

  Fly   390 KAWERLEKAEHERELALREELIRQEKLEQLAARFDRKASMRETWL--------SENQRLVSQDNF 446
            |.|.:|..|..|||.|||.|:.|.|.|:|:|.|..|.:.:.|..|        |:::||.|...|
Human   580 KEWGKLIIAMLEREKALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQF 644

  Fly   447 -------GFDLAAVEAAAKKHEAIETDI------FAYEERVQAVVAVCDEL-----ESERYHDVK 493
                   |:.|.. |...::| .|:..|      :..::.||.|..:.||:     |....:...
Human   645 QNEAEIAGYILEC-ENLLRQH-VIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNECSSVYSKG 707

  Fly   494 RILLRKD-------------------------------------------------------NVM 503
            |||..:.                                                       :|.
Human   708 RILTTEQTKLMISGITQSLNSGFAQTLHPSLTSGLTQSLTPSLTSSSMTSGLSSGMTSRLTPSVT 772

  Fly   504 RLWT--------------------YLLELLRARRMRLEISLQLQQNFQE----MLYILDNM---E 541
            ..:|                    ..|:|::.|:..|:.|| |.||..|    |.::.|.:   :
Human   773 PAYTPGFPSGLVPNFSSGVEPNSLQTLKLMQIRKPLLKSSL-LDQNLTEEEINMKFVQDLLNWVD 836

  Fly   542 EIKQLLMTDDYGKHLMGVEDLLQKH------------SLVEADINILGERVKVVVQNSQKFLSDD 594
            |::..|...::|..|..||..|:.|            ||.||.|:.:.....:.:..::|     
Human   837 EMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEK----- 896

  Fly   595 PESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIVS 659
                           :.:||..||:|:..:..:...|:   .|..|.....:|..|:.|||:   
Human   897 ---------------LHRLESQYAKLLNTSRNQERHLD---TLHNFVSRATNELIWLNEKEE--- 940

  Fly   660 TDEVGHDLTTVNLMLSK----HKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEIL 720
             :||.:|.:..|..:::    |..|..|:...:..:::|.::..:|:.|.|.....|:.....:.
Human   941 -EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQ 1004

  Fly   721 NKWDHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKD 785
            .:|..:|.|.:...|.::....||:.|.||                                 |:
Human  1005 TQWSWILQLCQCVEQHIKENTAYFEFFNDA---------------------------------KE 1036

  Fly   786 VADELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYK 850
            ..|.|:|..:.|...:....|..:::.|        :.:....:|..||.:.:.       ::..
Human  1037 ATDYLRNLKDAIQRKYSCDRSSSIHKLE--------DLVQESMEEKEELLQYKS-------TIAN 1086

  Fly   851 LMSEADGVEQWIKEKTK--MLDTMTPGK---DIEDVEIMKHRFEGFDKEMNANASRVAVVNQLAR 910
            ||.:|..:.| :|.:..  .|.|..|.|   |...:||..::.:......|::.::..|::....
Human  1087 LMGKAKTIIQ-LKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGN 1150

  Fly   911 QLL------HVEHPNSDEILERQNHLNQEWS---TLREKAEAKMDDLKSAHGVQTFYIECRETIS 966
            :.:      .|..||. |.::..|.:.|::.   ||..::                :|..:..:|
Human  1151 EAMVPSVCFTVPPPNK-EAVDLANRIEQQYQNVLTLWHES----------------HINMKSVVS 1198

  Fly   967 W---IEDKKRI-LTETDSLEMDLTG-----VMTLQRRLSGMDRDLAAIQ----AKLSSLEREANS 1018
            |   |.:..|| .:...|::..|.|     :..||.|......|....|    :.::.||:|.|.
Human  1199 WHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNV 1263

  Fly  1019 IEDEHPEEAKIIRERIAQIELIWEQLTQMLKERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVA 1083
            .:..:.|..| ..||..|.|.::......::....:||...|  |.:|.:          :|.:.
Human  1264 CKQYYQELLK-SAEREEQEESVYNLYISEVRNIRLRLENCED--RLIRQI----------RTPLE 1315

  Fly  1084 SEDTPTSLPEAEKLLNQHQSIREEIDNYTEDYKNMMEYGERLTSEGSTSDD-PQYMFLRERLNAL 1147
            .:|    |.|:...:.:.:.:::|::...:|...:....|...|:.:.|.. |.   ||..||.:
Human  1316 RDD----LHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPT---LRSELNVV 1373

  Fly  1148 KDGWEELHQMWENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHFLSKDDTPV----NLEQAENQL 1208
               .:.::|::......:.:.....|..::.:..|.|:...|..|.:::..:    |:|...:.|
Human  1374 ---LQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTL 1435

  Fly  1209 KRHEAFL----TTMEANDDKINTLLQVAD----TLVEKD-HFD-----ADKIGKRAENITGRRDD 1259
            |:..:.:    ....|.:|::.....::|    |..|:| .||     ||::.:|.:|: ..:.|
Human  1436 KQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNV-HVQID 1499

  Fly  1260 NRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATS---QDESYRSAKTIHSKWTRHQAFEA 1321
            ||.|.|:...|     .|..:......|.:|:|:...|.   |:....::||:.::..:.:...:
Human  1500 NRLRDLEGIGK-----SLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1559

  Fly  1322 EIAANKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKGAM---LFDANREV 1383
            ||...:.::.|.:|.|::.|....::         ||........|.:::|..:   ...::.::
Human  1560 EIEMKQSKMDECQKYAEQYSATVKDY---------ELQTMTYRAMVDSQQKSPVKRRRMQSSADL 1615

  Fly  1384 LVQQTCDDIDSY--ITDLEKQIV--SGDTANDLTSVNILMQKQQVIQTQMAVKARQVEEIDKQTE 1444
            ::|:..|....|  :..|..|.:  :||      |:..|.::::.::.:......:.:|:.|...
Human  1616 IIQEFMDLRTRYTALVTLMTQYIKFAGD------SLKRLEEEEKSLEEEKKEHVEKAKELQKWVS 1674

  Fly  1445 YLQKTVPE-----------EKI--EPIVVKKTAVLERFEKIKAPLL--------ERQKALEKKKE 1488
            .:.||:.:           :||  |.|..||..:.|..:.|:..|.        |.:..|||:.:
Human  1675 NISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVK 1739

  Fly  1489 AFQFCRDVEDEKLWIDEKL-PVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAI------ 1546
            ..|     |...|...|.| .:..|...|    :|.|.:|.::.:|..||.....:.::      
Human  1740 TLQ-----ESYNLLFSESLKQLQESQTSG----DVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLR 1795

  Fly  1547 ----CNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIENRRKHLLESEKVQQYFFDAQEAES 1607
                .:.|.:|:    |.......|||...:|..:||||    :.|.|                 
Human  1796 GLIDYDTGIRLL----ETQLMISGLISPELRKCFDLKDA----KSHGL----------------- 1835

  Fly  1608 WMSEQELYMMVE-DRGKDEISAQN--LMKKHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDA 1669
             :.||.|..:.| .:.|:.|||.:  .:...:.|.||:...:..|:.| |:.       :|:|..
Human  1836 -IDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVL-EIL-------LSTGSL 1891

  Fly  1670 V---AVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSRE--VDDLEQWITDREVVAGSQELGQ 1729
            |   ..:|..|.|.:         ::..::.||...:|.|:  ..||....|..:|..      .
Human  1892 VIPATGEQLTLQKAF---------QQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSL------I 1941

  Fly  1730 DFDHVTLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNESWQDLLEL 1794
            |....:.|.|....:........|.|:....|...::::|.|..                    |
Human  1942 DMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEG--------------------L 1986

  Fly  1795 IETRTQMLAASRELHKFFHDCKDVLGRILEK------------QHGVSDELGRD-AGSVSTLQRK 1846
            |:..|.....|.:|         :.|.::..            :.||.|   || |.|:.|.|.:
Human  1987 IDRETMFRLLSAQL---------LSGGLINSNSGQRMTVEEAVREGVID---RDTASSILTYQVQ 2039

  Fly  1847 HYNFLQ---------------DLITLYSQVQQIQEE------------------SAKLQDAYAGD 1878
            ....:|               ||||..|.:..::.:                  |:..|:....:
Human  2040 TGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNE 2104

  Fly  1879 KAKEITNREQEV--LHAWDNLQAM-CDARKQ-------------------KLADTGDLFRFFNMV 1921
            .|.:|.|..|::  |:..::.|.: .||.||                   |:.|.|||....|..
Human  2105 LAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPDLGDLEACKNAR 2169

  Fly  1922 RILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYAS 1986
            |    |:.....|.:|   ..|....|.:.:..:.:..:  |.|:.....:|    .|..|.|..
Human  2170 R----WLSFCKFQPST---VHDYRQEEDVFDGEEPVTTQ--TSEETKKLFLS----YLMINSYMD 2221

  Fly  1987 ADIKDRLMTLSNSRNALLRRWEERWENLQLILE--VYQFARDAAVAEAW-LIAQEPYLLSSELGH 2048
            |:...||:......:          |.:.::||  ..:|..:.|:.|.. :::.....|::..|.
Human  2222 ANTGQRLLLYDGDLD----------EAVGMLLEGCHAEFDGNTAIKECLDVLSSSGVFLNNASGR 2276

  Fly  2049 TIDEVENLIKKHEAFEKSAAAQEERFSALERLTTFELKEMKRRQELAEEAERQR---IKEE--QE 2108
            ..||   ......:|.|....:.|.....|          .|:..:.||....|   |..|  |.
Human  2277 EKDE---CTATPSSFNKCHCGEPEHEETPE----------NRKCAIDEEFNEMRNTVINSEFSQS 2328

  Fly  2109 AKAASEAAEQAKREAE-------------RRDDVDVGASHDDSAAKDTAVEFERVVEIQT-ERGG 2159
            .|.||..:...|..:.             :.:..|:.....||  ::....:|....::| ||..
Human  2329 GKLASTISIDPKVNSSPSVCVPSLISYLTQTELADISMLRSDS--ENILTNYENQSRVETNERAN 2391

  Fly  2160 TPGAGEGHEGY-------------------VTRKHEWDSTTKKA-----SNR-----SWDKVYMA 2195
            .....:..:.:                   |......|:|.:.:     |.|     |.||:..:
Human  2392 ECSHSKNIQNFPSDLIENPIMKSKMSKFCGVNETENEDNTNRDSPIFDYSPRLSALLSHDKLMHS 2456

  Fly  2196 AKAGRISFYKDQKGYKSN-PELTFR----------GEPSYD--LQNAAIEIA---SDYTKKKHVL 2244
            ..:...:...:..|.|.. |.|:|.          ||...|  |..|||.|:   ..|.:|.  |
Human  2457 QGSFNDTHTPESNGNKCEAPALSFSDKTMLSGQRIGEKFQDQFLGIAAINISLPGEQYGQKS--L 2519

  Fly  2245 RVKLANGALFLLQAHDDTEMSQWVTSLKAQSDSTAVAASRSQTLPATSQKDEPK 2298
            .:..:|..   :|.|:|    :::::...:.:         :|.|...|..|.|
Human  2520 NMISSNPQ---VQYHND----KYISNTSGEDE---------KTHPGFQQMPEDK 2557

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 57/129 (44%)
CH 170..269 CDD:278723 55/98 (56%)
Spectrin 298..408 CDD:278843 33/114 (29%)
SPEC 422..521 CDD:197544 29/199 (15%)
SPEC 525..740 CDD:238103 49/237 (21%)
SPEC 639..846 CDD:238103 37/210 (18%)
SPEC 848..1058 CDD:238103 48/236 (20%)
SPEC 955..1169 CDD:238103 44/227 (19%)
SPEC 1170..1380 CDD:238103 45/233 (19%)
SPEC 1386..1484 CDD:197544 23/122 (19%)
SPEC 1488..1699 CDD:238103 46/227 (20%)
SPEC 1594..1806 CDD:238103 39/219 (18%)
SPEC 1807..2015 CDD:238103 51/275 (19%)
Spectrin 2018..>2078 CDD:278843 12/62 (19%)
PH 2167..2275 CDD:278594 28/152 (18%)
PH_beta_spectrin 2167..2274 CDD:269975 28/151 (19%)
DSTXP_016866694.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0517
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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