Protein Alignment beta-Spec and actn2b

DIOPT Version :9

• Sequence 1: NP_001259660.1
• Gene: beta-Spec / 32746
• FlyBaseID: FBgn0250788
• Length: 2308
• Species: Drosophila melanogaster
• Sequence 2: NP_001032662.1
• Gene: actn2b / 641575
• ZFINID: ZDB-GENE-051127-39
• Length: 895
• Species: Danio rerio
• Alignment Length: 980
• Identity: 304/980 - (31%)
• Similarity: 467/980 - (47%)
• Gaps: 222/980 - (22%)

  Fly    18 NEY-IDEY-----EYDGGNSSSRLFERSRIKALAEERESVQKKTFTKWVNSHLCRVNCRIADLYV 76
            |.| ||||     |:|            |...|....|..|:||||.|.||.|.:...:|.::..
Zfish    13 NGYEIDEYMMQEDEWD------------RDLLLDPAWEKQQRKTFTAWCNSRLRKAGTQIENIEE 65

  Fly    77 DMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASL 141
            |.|:|..|:.||||:||||||||.:||||.|.:.||:|||.|:..:.|.|.:||:.:|||||..:
Zfish    66 DFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALDFITSKGVKLVSIGAEEIVDGNVKM 130

  Fly   142 NLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNA 206
            .||:||||||||.||||::||.      |||:.||||||.|||.|.||||:||..||:||||..|
Zfish   131 TLGMIWTIILRFAIQDISVEET------SAKEGLLLWCQRKTAPYRNVNVQNFHVSWKDGLALCA 189

  Fly   207 IIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVF-VEHPDEKSIITYVVTYY 270
            :||:|||||:.:.||:|.:.:.|||.|||:||..|.:.|:|||||:. ...|||::|:|||..:|
Zfish   190 LIHRHRPDLIDYAKLNKDDPLGNLNLAFDIAEKHLDIPKMLDAEDILSTPKPDERAIMTYVSCFY 254

  Fly   271 HYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQG 335
            |.|:..:|......||.||:|:..||:|::.|||...|:||:||..||..|..|..|.::..:|.
Zfish   255 HAFAGAEQAETAANRICKVLGVNQENEKLMEDYERLASELLEWIRRTIPWLENRAAEKTMVEMQR 319

  Fly   336 QLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKAEH 400
            :|..|.:||.:.||||..||..||:...|||:|:|.:|:..:.|.||||:|||..||:.||:||.
Zfish   320 KLEDFRDYRRMHKPPKVQEKCQLEISFNTLQTKLRISNRPAFMPSEGKMVSDIASAWQGLEQAEK 384

  Fly   401 ERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNF-GFDLAAVEAAAKKHEAIE 464
            ..|..|..|:.|.|::|.||.:|.:|||..|:|.:..:.::::.:: ...|..|.|..:||||.|
Zfish   385 GYEEWLLTEIRRLERVEHLAEKFRQKASNHESWATGKEEMLTRKDYESASLMEVRALLRKHEAFE 449

  Fly   465 TDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQN 529
            :|:.|:::||:.:.|:..||....||||..:..|..::..||.:|..|.:.||..||.:.:|
Zfish   450 SDLSAHQDRVEQIAAIAQELNELDYHDVASVNQRCQSICDLWDHLGTLTQRRREALERTEKL--- 511

  Fly   530 FQEMLYILDNMEEIKQLLMTDDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSDD 594
                      :|.:.||.:  :|.|.
Zfish   512 ----------LETVDQLFL--EYAKR--------------------------------------- 525

  Fly   595 PESYKPCDPEIIVSRVQQLEDAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIVS 659
                                                             :|...||::...:.:.
Zfish   526 -------------------------------------------------SAPFNNWMEGAMEDLQ 541

  Fly   660 TDEVGHDLTTVNLMLSKHKALESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRL-------- 716
            ...:.|.:..|..:::.|:..::.::..|.:.|.:..:..|::.  .|.:..|:..|
Zfish   542 DMFIVHTIEEVQTLIAAHEQFKATLSEADAERQAILGIQQEVLK--IFQSYGIRGDLTNPYSTIT 604

  Fly   717 -KEILNKWDHLLDLTKYRRQRL------ENAVEYF--QLFADADDVDNWMLDTLRIVSSEDVGRD 772
             :||..|||.:..|...|...|      ::|.|..  |..|.|:.:..|:...:     |::|..
Zfish   605 AEEIAIKWDKVKKLVPQRDSALQEELARQHANERLRRQFAAQANLIGPWIQTRM-----EEIGHC 664

  Fly   773 EANVQSLLKKHKDVADELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEA----------IDNR 827
            ...:...|   :|...:||.|..||             .:.|:|:| |||.          .||:
Zfish   665 SMAMGGTL---EDQMTQLKQYEHVI-------------VSYKSNID-RLEGDHQLIQESLIFDNK 712

  Fly   828 YKELT--------ELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTPGKDIEDVEIM 884
            :...|        ||......|.::.:....|..:|.|:.|                  |.:...
Zfish   713 HTNYTMEHVRVGWELLLTTIARTINEIETQILTRDAKGISQ------------------EQMHEF 759

  Fly   885 KHRFEGFDKE----MNANASRVAVVN--------QLARQLLHVEHPNSDEILERQNHLNQEWSTL 937
            :..|..||::    |:::..|..:::        :.||.::.|: ||:...:..|:.:  ::.|
Zfish   760 RSSFNHFDRKENGGMDSDDFRACLISMGYDLGEVEFARIMMLVD-PNASGNVSFQSFI--DFMT- 820

  Fly   938 REKAE 942
            ||.|:
Zfish   821 RETAD 825

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
beta-Spec	NP_001259660.1	CH	51..149	CDD:278723	50/97 (52%)
		CH	170..269	CDD:278723	58/99 (59%)
		Spectrin	298..408	CDD:278843	49/109 (45%)
		SPEC	422..521	CDD:197544	32/99 (32%)
		SPEC	525..740	CDD:238103	26/229 (11%)
		SPEC	639..846	CDD:238103	47/241 (20%)
		SPEC	848..1058	CDD:238103	20/107 (19%)
		SPEC	955..1169	CDD:238103
		SPEC	1170..1380	CDD:238103
		SPEC	1386..1484	CDD:197544
		SPEC	1488..1699	CDD:238103
		SPEC	1594..1806	CDD:238103
		SPEC	1807..2015	CDD:238103
		Spectrin	2018..>2078	CDD:278843
		PH	2167..2275	CDD:278594
		PH_beta_spectrin	2167..2274	CDD:269975
actn2b	NP_001032662.1	CH	43..141	CDD:214479	52/97 (54%)
		CH	153..258	CDD:237981	60/104 (58%)
		Spectrin	282..391	CDD:278843	48/108 (44%)
		SPEC	403..630	CDD:238103	62/331 (19%)
		Spectrin	638..740	CDD:278843	25/123 (20%)
		EFh	758..820	CDD:238008	11/64 (17%)
		EFhand_Ca_insen	825..891	CDD:285885	0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D543832at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920