DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and Sptbn5

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_036018336.1 Gene:Sptbn5 / 640524 MGIID:2685200 Length:3742 Species:Mus musculus


Alignment Length:2481 Identity:624/2481 - (25%)
Similarity:1124/2481 - (45%) Gaps:340/2481 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 FERSRIKALAEERESVQKKTFTKWVNS--HLCRVNCRIADLYVDMRDGKHLIKLLEVLSGERLPK 98
            :|...::.|..:...:|:||||.|:|:  .|.||..||.:||.:..||.||::|||::|||.||.
Mouse    87 YEIGHVRKLQAQHTHMQEKTFTNWINNIFRLGRVGIRIQNLYTEFADGAHLLRLLELISGEALPA 151

  Fly    99 PTKGKMRIHCLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEV 163
            |:.|::|:|.|||...||.||| .:|.:..||..:||||:.||.|||:|.|||||||..|:::..
Mouse   152 PSPGRLRVHFLENNSHALAFLR-AKVPIPFIGPENIVDGDQSLILGLLWVIILRFQISHISLDRE 215

  Fly   164 D---NKETKSAKDALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLSKTN 225
            :   :....|||:|||:|||.|||||.||::.:|:.||.|||.|||::|.|||||:.:..||...
Mouse   216 EFGASAALLSAKEALLVWCQRKTAGYTNVDITDFSRSWSDGLGFNALLHAHRPDLLDYGSLSPDR 280

  Fly   226 AIHNLNNAFDVAEDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYFSKLKQETVQGKRIGKVV 290
            .::||:.||.|||.:||:|:|||.|||...||||.||:||:..||||||:|::.....:|:.|::
Mouse   281 PLYNLSFAFRVAEQQLGIAQLLDPEDVAALHPDECSIMTYLSQYYHYFSRLQRGHTAQRRLAKIL 345

  Fly   291 GIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFENSLAGVQGQLAQFSNYRTIEKPPKFVEK 355
            ....|.:.:...|:...:|||.|||.....|..|:|.:||..::..||.|:::|..||||::.::
Mouse   346 LQLQETEVLQAQYKQLVADLLCWIEEKKMQLEARDFPDSLPAMRQLLAAFASFRAREKPPRWQQR 410

  Fly   356 GNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKAWERLEKAEHERELALREELIRQEKLEQLA 420
            |..|.|||.||:.:||.|::|:.|:||...:::.:.|..||:||..|..|:::.|::.|:|:.||
Mouse   411 GATEALLFQLQTTLRAQNRRPFLPREGLGPAELAQRWAELERAEACRSQAMQQRLLQLERLDTLA 475

  Fly   421 ARFDRKASMRETWLSENQRLVSQDNFGF-DLAAVEAAAKKHEAIETDIFAYEERVQAVVAVCDEL 484
            .||..|||.||::|::.::::.|..... |.|.||||.::...:|..|...|.|.||:..:.|.|
Mouse   476 RRFQCKASHRESFLNDVEQMLDQARASLTDPATVEAATQRLSVLEAAILPQEGRFQALGEMADIL 540

  Fly   485 ESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQLQQNFQEMLYILDNMEEIKQLLMT 549
            ..|.||....:..|:..:...|..||..|:..|.|:|.|..:....|.:..:...:.|::.|..:
Mouse   541 RQEEYHSWADMARRQKEITGRWRRLLRCLQEERKRMEDSKAVLSLLQGVEAVTHQLGELQVLASS 605

  Fly   550 DDYGKHLMGVEDLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYKPCDPEIIVSRVQQLE 614
            ..||:.|..:..|||.|.|:||.::.....|..:|..:.:..|      :....|::.::...|.
Mouse   606 TVYGQQLAEIVSLLQSHDLLEAQVSAHRTHVTHLVHQTTQLDS------QGTSVEVLQAKALALA 664

  Fly   615 DAYAELVRLAVERRSRLEESRKLWQFYWDTADEENWIKEKEQIVSTDEVGHDLTTVNLMLSKHKA 679
            :.:..||.|...||:.||::.:..||.....:||.|::|..|::.|..:..|||.:...|.||||
Mouse   665 ELHHSLVSLVRARRTLLEQTLQRAQFLRSCEEEEAWLQEHRQLMETAVLDRDLTQIATALQKHKA 729

  Fly   680 LESEITSHDPQLQNVAKVGSELITEGHFGADRIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYF 744
            ||:|:..|.....::.:.|...............:|.:.:...|..|......||.||:.|:...
Mouse   730 LETELHRHQAVCVDLMQRGRNFSVREPLTQPDPLERAEAVQGTWQLLWAGAARRRARLQTALLIG 794

  Fly   745 QLFADADDVDNWMLDTLRIVSSEDVGRDEANVQSLLKKHKDVADELKNYAEVIDALHKQAESL-- 807
            |.|:|:.:..:|:....:.:.|...|:|:|:.::||.:|..:..:::.:|..:..|.:||.:.  
Mouse   795 QYFSDSAEAASWLFQRQKQLESASCGKDQADAEALLLQHLRLEQDVRAFAAELRELEEQARAAAA 859

  Fly   808 ----------------------------------------------------------------- 807
                                                                             
Mouse   860 LVSHMVHTGTWKGSRLVSPTPNEEPPEDWKRLGRDTIGGPQGETQVLAAPGSHYSHQQIAFFSRE 924

  Fly   808 ------KLNEAEKA--------NVDKR-------------------------------LEA---I 824
                  ||.|...:        :::|:                               |:|   :
Mouse   925 EAPNTWKLEELGDSQSRMAIIHSIEKKPQVLSALGFLGEGPRTVLQAENDVHFNSSTILQAQADV 989

  Fly   825 DNRYKELTELAKLRKQRLLDALSLYKLMSEADGVEQWIKEKTKMLDTMTP-GKDIEDVEIMKHRF 888
            ...|::|..||||.:.||.::::|:...|....::.|::::|.:..|:.| |.::|.:::   ::
Mouse   990 SQTYEKLRALAKLHRTRLEESIALFSFYSSCRELQSWLEKQTALFQTLQPQGHNLEVIQL---KY 1051

  Fly   889 EGFDKEMNANASRVAVVNQLARQLLHVEHPNSDEILERQNHLNQEWSTLREKAEAKMDDLKSAHG 953
            |.....:.......|.....|.||......:..:|.::|..|.|.|..|....|.|:  |:...|
Mouse  1052 ENVLMTLATGKGHWAEAINTAEQLKQRCPGHISKIQQQQEDLKQRWQQLEALKEEKL--LQLTRG 1114

  Fly   954 VQTFYIECRETISWIEDKKRILTETDSLEMDLTGVM----TLQRRLSG--------MDRDLAAIQ 1006
            ::.    |           .:|.|::.::..|..|:    ||..|.||        ..:.:..::
Mouse  1115 MEV----C-----------SLLQESEPIQAQLLNVISRLETLGTRSSGDSHHTLQQTQQKVLVLE 1164

  Fly  1007 AKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQ---LTQMLKE------RDSKLEEAGDLH 1062
            .|:|.|:|....:.:....|::          |:|||   |..:||:      |..:::....:.
Mouse  1165 KKISYLQRATIEVMESGSPESR----------LLWEQVLMLQSLLKQAQGQVARQIQVQTVARVQ 1219

  Fly  1063 R-FLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQHQSIREEIDNYTEDYKNMMEYGERLT 1126
            | .|::......|....|..:.|::.......|.:.|.:|.:::||...:.|..:.:...|:.: 
Mouse  1220 RGILQESQKLLLWAEDIQAQLCSKEERQVEASALRPLRRHGTLQEETCLWEERLQQLEAQGQPV- 1283

  Fly  1127 SEGSTSDDPQYMFLRERLNALKDGWEELHQMWENRQVLLSQSLDQQLFNRDARQTEVLLSQQEHF 1191
               :.||.||...:...|..|....::|..:||.||....:.|:.|.|.::........:..|..
Mouse  1284 ---AVSDSPQSQEVASALRLLGQHSQQLKALWEQRQQKFWEGLELQGFGQEVDDFMATCASHEAL 1345

  Fly  1192 LSKDDTPVNLEQAENQLKRHEAFLTTMEANDDKINTLLQVADTLVEKDHFDADKIGKRAENITGR 1256
            |..|:...::.:|::.|::|:...........:...|....:.|:........||.:...:...:
Mouse  1346 LQLDNLGEDIREAQSLLQQHQGLGWLRSTLGSRAEALRARGEKLLLSHPAAVSKIRELLHSAQAQ 1410

  Fly  1257 RDDNRQRALDQHEKLKNQVKLHEFLQDLEELAEWVQEKYATSQDESYRSAKTIHSKWTRHQAFEA 1321
            ....::|:..:..:|...::|.|:.|..|.|..|::||:....||..::...|..|....:..::
Mouse  1411 WTRVQERSEQRRVQLLASLQLQEWKQAEEGLMLWMEEKWPRVADERSQAGSNILQKLKWRKITKS 1475

  Fly  1322 EIAANKERLFEAEKSAQELSKEKPEFKDVIEPKLKELAKQFDDLEVHTKEKGAMLFDANREVLVQ 1386
            |:.|::..:.|.:::.:||....|..::.|:.:|:.|..::::|....:::|..|....::..:.
Mouse  1476 ELLASRRYMEELQQAGKELLHSNPYAQEDIQDRLQSLNHKWEELNHKMEDRGDRLPQTRQQDQLL 1540

  Fly  1387 QTCDDIDSYITDLEKQIVSGDTANDLTSVNILMQKQQVIQTQMAVKARQVEEIDKQTE--YLQKT 1449
            :...|:...:..||..:.|.:|..||.|...|.::...::.:....|.:::.:..||.  :...|
Mouse  1541 ELIQDVQETMEHLEGALQSTETGQDLCSSRRLQRQHCKLEDKSQALASKMDALISQTHNAFTSWT 1605

  Fly  1450 VPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKKEAFQFCRDVEDEKLWIDEKLPVA--NS 1512
            :.||        .....:||:.:::.|..:.:.|:...|.::|......|..|..|.:|.|  |.
Mouse  1606 ILEE--------SQKCHQRFKSLQSKLATQHQQLQASVELYEFNLLSNLELTWAAEHMPNAALNC 1662

  Fly  1513 PDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAKKFEALISDLTQKWQE 1577
            |  .....:.|.|::|::.|..|:..|...:..:.::|::|...||..|:........|...|..
Mouse  1663 P--AQCWHDAHSLQRKHKMLQAEVKGHVRHMYRVLSSGQRLAASGHPRAQHIVEQCQKLESHWAG 1725

  Fly  1578 LKDAIENRRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSV 1642
            |:.|.|.|...|.::..|||||.:..|.|:|:.|:......:|.|.:|.:...|::||:.|:|.|
Mouse  1726 LEQACEERAHCLQQAVTVQQYFLNVSEMETWVEEKRPLASSQDYGSNEEATSGLIRKHQMLQQEV 1790

  Fly  1643 EDYANTIRQLGEVARQFSGDDISSGDAVAVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSRE 1707
            ..|.:::..|.:..:..:  :..:.:.:.|.:.:|.    .|:.||.||...|...|:|....||
Mouse  1791 ALYWSSMEDLEQRFQTLA--EFEAPERLGVVREKLQ----ALRKLADERGQELEGTLRLHEFMRE 1849

  Fly  1708 VDDLEQWITDREVVA-GSQELGQDFDHVTLLSERFNEFARDTEAVGGERVAKVNGIADNLIQAGH 1771
            .:||:.|::.|:.|| |....|:|.:||..|...|.:|....| .|.:||.....:|::|.:.||
Mouse  1850 AEDLQSWLSSRKQVARGGDTFGEDHEHVLQLCTEFTKFQYQVE-TGAQRVETCRLLAESLQERGH 1913

  Fly  1772 SDSATIAEWKDNLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHGVSDELGRD 1836
            |.:....:.:.::..||.:|.:|.:.|:::|..:....:...|..:||.:|.||...:.:::.:|
Mouse  1914 SAAPKAHQRQQDIQASWSELCQLTQARSRLLNDAEITLRVHGDLLEVLTQIQEKATSLPNDVAQD 1978

  Fly  1837 AGSVSTLQRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKA-KEITNREQEVLHAWDNLQAM 1900
            ...|....::|....::|..:..|||::.:...::|:...|.:| ..:..::|.|..||:.||..
Mouse  1979 LCGVENQLQRHERLERELAGMEQQVQELMKAGGRVQELCPGTQALAAVQQKQQAVTQAWEALQLR 2043

  Fly  1901 CDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNHQSLKAEIDTRE 1965
            .:.||.:|.....|.||...||....|...:.:::...|...:...:.|.:..||.|.||:..:|
Mouse  2044 MEQRKAQLERGYLLVRFHTAVRDYTSWAASVHQELQMEEASWEPHSLLLRLRAHQWLWAELKAKE 2108

  Fly  1966 DNFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALLRRWEERWENLQLILEVYQFARDAAVA 2030
            :.......:|::.|.... ..|.::|.|.||...|:.:.:.|..:.|.||.:|:.....|.....
Mouse  2109 ELQQRATKMGQQALLAAG-TPAKVQDGLRTLQEERDQVFQAWALKQEKLQAMLQEQHLLRQCGHL 2172

  Fly  2031 EAWLIAQEPYLLSSELGHTIDEVENLIKKHEAFEKSAAAQEERFSAL------------ERLTTF 2083
            ...|.|||.:|.:|.||.:::|||.||:||..|:|..|.|:::.:.|            |:|.|.
Mouse  2173 VEVLTAQEAFLKASGLGSSVEEVEQLIRKHVIFQKVLALQDKKVTGLNIVADGGESALNEQLKTI 2237

  Fly  2084 -----------------ELKEM--KRRQEL---------------AEEAERQRI----------- 2103
                             ::||:  .|.|.|               ||:..:||:           
Mouse  2238 SSPKGQNLFCHMLEHRAQVKELAESRGQALHTSLMIGNFVRAATQAEDWIQQRVQQLRAWSPLGN 2302

  Fly  2104 --------KEEQEAKAASEAAEQAKREAERRDDVDVGASHDDSAAKDTAVEFERVVEIQTERGGT 2160
                    ::.|..:|..:|.||......::.:..:..||                         
Mouse  2303 LKDYLKHLRKHQAFRAEVQAQEQILTSVAKQGEELLSQSH------------------------- 2342

  Fly  2161 PGAGEGHEGYVTRKHEWDSTTKKASNRSWDKVYMAAKAGRISFYKDQKGYKSNPELTFRG---EP 2222
            |.|||     |:::.|       |....|:|:..|                    :|.:|   |.
Mouse  2343 PQAGE-----VSQRLE-------ALRDLWEKLRQA--------------------VTLQGQALEN 2375

  Fly  2223 SYDLQN--AAIEIASDYTKKKHVLRVKLANGALFLLQAHDDTEMSQWVTSLKAQSDSTAVAASRS 2285
            .|:.|.  ..:::|..:.::|.    ::.|.....|......::.:.|..|:...|...:...::
Mouse  2376 RYNFQEFLQRVDLAETWIQEKE----RMVNSCDIGLNLEHCLQLCRQVRRLQVTVDDAHIKGIKN 2436

  Fly  2286 QTLPATSQKDE 2296
            .:|...:|..|
Mouse  2437 LSLQLKNQGPE 2447

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 51/99 (52%)
CH 170..269 CDD:278723 57/98 (58%)
Spectrin 298..408 CDD:278843 41/109 (38%)
SPEC 422..521 CDD:197544 33/99 (33%)
SPEC 525..740 CDD:238103 53/214 (25%)
SPEC 639..846 CDD:238103 58/321 (18%)
SPEC 848..1058 CDD:238103 46/231 (20%)
SPEC 955..1169 CDD:238103 46/235 (20%)
SPEC 1170..1380 CDD:238103 38/209 (18%)
SPEC 1386..1484 CDD:197544 18/99 (18%)
SPEC 1488..1699 CDD:238103 55/212 (26%)
SPEC 1594..1806 CDD:238103 61/212 (29%)
SPEC 1807..2015 CDD:238103 49/208 (24%)
Spectrin 2018..>2078 CDD:278843 22/71 (31%)
PH 2167..2275 CDD:278594 17/112 (15%)
PH_beta_spectrin 2167..2274 CDD:269975 17/111 (15%)
Sptbn5XP_036018336.1 CH_SPTBN5_rpt1 83..207 CDD:409096 58/120 (48%)
CH_SF 222..330 CDD:412120 62/107 (58%)
SPEC 357..579 CDD:413338 80/221 (36%)
SPEC 474..685 CDD:238103 62/216 (29%)
SPEC 585..791 CDD:238103 53/211 (25%)
SPEC 795..>856 CDD:197544 15/60 (25%)
SPEC <976..1111 CDD:413338 32/139 (23%)
SPEC 1223..1318 CDD:197544 22/98 (22%)
SPEC 1324..1532 CDD:238103 38/207 (18%)
SPEC 1538..1740 CDD:238103 46/211 (22%)
SPEC 1669..1838 CDD:238103 45/174 (26%)
SPEC 1842..2052 CDD:238103 56/210 (27%)
SPEC 1952..2160 CDD:238103 51/208 (25%)
SPEC 2161..2375 CDD:238103 52/270 (19%)
SPEC 2276..2481 CDD:238103 36/233 (15%)
SPEC 2484..2682 CDD:238103
SPEC 2588..2797 CDD:238103
SPEC 2800..3010 CDD:238103
SPEC 3011..3222 CDD:238103
SPEC 3223..3458 CDD:238103
SPEC 3462..>3630 CDD:238103
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D15759at33208
OrthoFinder 1 1.000 - - FOG0000586
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100348
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.