DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment beta-Spec and Actn4

DIOPT Version :9

Sequence 1:NP_001259660.1 Gene:beta-Spec / 32746 FlyBaseID:FBgn0250788 Length:2308 Species:Drosophila melanogaster
Sequence 2:XP_006540320.1 Gene:Actn4 / 60595 MGIID:1890773 Length:934 Species:Mus musculus


Alignment Length:906 Identity:306/906 - (33%)
Similarity:475/906 - (52%) Gaps:97/906 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 RWDPSQGPGNEYIDEYEYDGGNSSSRL------FERSRIKALAEERESVQKKTFTKWVNSHLCRV 67
            ::.|:.|.||      ...||.|....      ::|..:...|.|::  |:||||.|.||||.:.
Mouse    12 QYGPNSGGGN------GAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQ--QRKTFTAWCNSHLRKA 68

  Fly    68 NCRIADLYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIHCLENVDKALQFLREQRVHLENIGSH 132
            ..:|.::..|.|||..|:.||||:||||||||.:||||:|.:.||:|||.|:..:.|.|.:||:.
Mouse    69 GTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAE 133

  Fly   133 DIVDGNASLNLGLIWTIILRFQIQDITIEEVDNKETKSAKDALLLWCQMKTAGYHNVNVRNFTTS 197
            :||||||.:.||:||||||||.||||::||.      |||:.||||||.|||.|.||||:||..|
Mouse   134 EIVDGNAKMTLGMIWTIILRFAIQDISVEET------SAKEGLLLWCQRKTAPYKNVNVQNFHIS 192

  Fly   198 WRDGLAFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVAEDKLGLAKLLDAEDVF-VEHPDEKS 261
            |:|||||||:||:|||:|::::||.|.:.:.||||||:|||..|.:.|:|||||:. ...||||:
Mouse   193 WKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKA 257

  Fly   262 IITYVVTYYHYFSKLKQETVQGKRIGKVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREF 326
            |:|||.::||.||..::......||.||:.:..||:.::.|||...||||:||..||..|.:|..
Mouse   258 IMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYERLASDLLEWIRRTIPWLEDRVP 322

  Fly   327 ENSLAGVQGQLAQFSNYRTIEKPPKFVEKGNLEVLLFTLQSKMRANNQKPYTPKEGKMISDINKA 391
            :.::..:|.:|..|.:||.:.||||..||..||:...|||:|:|.:|:..:.|.||:|:||||..
Mouse   323 QKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNG 387

  Fly   392 WERLEKAEHERELALREELIRQEKLEQLAARFDRKASMRETWLSENQRLVSQDNF-GFDLAAVEA 455
            |:.||:||...|..|..|:.|.|:|:.||.:|.:|||:.|.|....:.::.|.:: ...|:.::|
Mouse   388 WQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKQRDYETATLSDIKA 452

  Fly   456 AAKKHEAIETDIFAYEERVQAVVAVCDELESERYHDVKRILLRKDNVMRLWTYLLELLRARRMRL 520
            ..:||||.|:|:.|:::||:.:.|:..||....|:|...:..|...:...|..|..|..:||..|
Mouse   453 LIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDNLGSLTHSRREAL 517

  Fly   521 EIS---------LQLQ----------------QNFQEMLYILDNMEEIKQLLMTDDYGKHLMGVE 560
            |.:         |.|:                ::.|:| :|:..:|||:.|:...|..|..:...
Mouse   518 EKTEKQLETIDQLHLEYAKRAAPFNNWMESAMEDLQDM-FIVHTIEEIEGLISAHDQFKSTLPDA 581

  Fly   561 DLLQKHSLVEADINILGERVKVVVQNSQKFLSDDPESYKPCDPEIIVSRVQQLEDAYAELVRLAV 625
            |..:     ||.:.|..|..::...|..|....:|  |....|:||.|:.::::....:.....:
Mouse   582 DRER-----EAILAIHKEAQRIAESNHIKLSGSNP--YTTVTPQIINSKWEKVQQLVPKRDHALL 639

  Fly   626 ERRSRLEESRKLWQFYWDTADEEN----WIKEK-EQI--VSTDEVGHDLTTVNLMLSKHKALESE 683
            |.:|:.:.:..|.:.:   |.:.|    ||:.| |:|  :|.:..|    |:...||..|..|..
Mouse   640 EEQSKQQSNEHLRRQF---ASQANMVGPWIQTKMEEIGRISIEMNG----TLEDQLSHLKQYERS 697

  Fly   684 ITSHDPQLQNVAKVGSELITEG-HFGADRIKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLF 747
            |..:.|.| ::.:...:||.|. .|........::.|...|:.||.........:||.:    |.
Mouse   698 IVDYKPSL-DLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQI----LT 757

  Fly   748 ADADDVDNWMLDTLRIVSSEDVGRDEANV-------QSLLKKHKDVADELKNYAEVIDALHKQA- 804
            .||..:....:...| .|.....:|....       ..|:....||.::.:.....:|:...:| 
Mouse   758 RDAKGISQEQMQEFR-ASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQKQTGSMDSDDFRAL 821

  Fly   805 ---ESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYKLMSEADGVEQWI 862
               ....|.:||   .::.:..:|..:..|...     |..:|.:|  :..::.|..:|.|
Mouse   822 LISTGYSLGDAE---FNRIMSVVDPNHSGLVTF-----QAFIDFMS--RETTDTDTADQVI 872

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
beta-SpecNP_001259660.1 CH 51..149 CDD:278723 53/97 (55%)
CH 170..269 CDD:278723 61/99 (62%)
Spectrin 298..408 CDD:278843 47/109 (43%)
SPEC 422..521 CDD:197544 29/99 (29%)
SPEC 525..740 CDD:238103 52/238 (22%)
SPEC 639..846 CDD:238103 45/225 (20%)
SPEC 848..1058 CDD:238103 3/15 (20%)
SPEC 955..1169 CDD:238103
SPEC 1170..1380 CDD:238103
SPEC 1386..1484 CDD:197544
SPEC 1488..1699 CDD:238103
SPEC 1594..1806 CDD:238103
SPEC 1807..2015 CDD:238103
Spectrin 2018..>2078 CDD:278843
PH 2167..2275 CDD:278594
PH_beta_spectrin 2167..2274 CDD:269975
Actn4XP_006540320.1 SAC6 49..>312 CDD:227401 146/270 (54%)
Spectrin 294..403 CDD:334073 46/108 (43%)
SPEC 415..641 CDD:238103 57/233 (24%)
SPEC 533..755 CDD:238103 52/237 (22%)
FRQ1 763..>894 CDD:227455 19/121 (16%)
EFhand_Ca_insen 864..930 CDD:312305 3/9 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D543832at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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